Kavli Affiliate: Michael Miller | Authors: Lei Liu, Yin Zheng, Luke Slominski, Qimin Quan, Adriana Saba, Jean-Pierre Bellier, Han-Bin Yoo, Andrea Roman, Elizabeth L Hennessey, Samadhi Wijethunga, Elif Lara Okyay, Michael B Miller, Hyun-Sik Yang, Dennis J Selkoe and Jasmeer Chhatwal | Summary: Background Alternative splicing of the MAPT gene produces distinct tau isoforms in […]
Kavli Affiliate: Michela Gallagher | Authors: Rebecca P. Haberman, Ana Delgado, Meifang Xiao, Ming Teng Koh, Ashley A Becker, Shiyu Ji, Paul F Worley, Michela Gallagher and Audrey E. Branch | Summary: Changes in synaptic integrity and neural activity homeostasis are hallmarks of brain aging and are closely tied to cognitive outcomes. Yet, defining their […]
Kavli Affiliate: Reza Shadmehr | Authors: Alkis M. Hadjiosif, Kahori Kita, Scott T. Albert, Robert A. Scheidt, Reza Shadmehr and John W. Krakauer | Summary: Moving and holding still have been posited to be under separate control regimes for both eye and arm movements. The paretic arm after stroke is notable for abnormalities both at […]
Kavli Affiliate: Richard Huganir | Authors: Sheridan Cavalier, Paul W Hook, Richard L. Huganir and Winston Timp | Summary: Neural activity drives transcriptional events that are critical for learning. Activity-induced transcript isoform expression and alternative splicing are cell-type specific events typically obscured by sequencing approaches that restrict read length. We combined single-cell transcriptomics with Nanopore […]
Kavli Affiliate: Seth Blackshaw | Authors: Pin Lyu, Isabella Palazzo, yang jin, Leah Campbell, Clayton Santiago, Rogger Carmen-Orzoco, Thanh Hoang, Jared Tangeman, Alexander Park, Shawn Yang, Jianming Shao, Rui Chen, David Hyde, Jiang Qian and Seth Blackshaw | Summary: Biological age is a major risk factor in the development of common degenerative retinal diseases such […]
Kavli Affiliate: Keri Martinowich | Authors: Jorge Alberto Miranda-Barrientos, Suhaas Adiraju, Jason J Rehg, Michael S Totty, Henry Hallock, Ye Li, Greggory Carr and Keri Martinowich | Summary: Sustained attention, the ability to focus on a stimulus or task over extended periods, is crucial for higher level cognition, and is impaired across multiple neuropsychiatric and […]
Kavli Affiliate: Jean Fan | Authors: Caleb Hallinan, Calixto-Hope G Lucas, Jr. and Jean Fan | Summary: Abstract Spatial transcriptomics technologies enable high-throughput quantification of gene expression at specific locations across tissue sections, facilitating insights into the spatial organization of biological processes. However, high costs associated with these technologies have motivated the development of deep […]
Kavli Affiliate: Jin Kang | Authors: Jaeho Ji, Ahrum Son, Mi-Jin Kang, Jeonghun Yeom, Hyun Ju Yoo, Kwoneel Kim, Jeong-Hyun Kim, Hea Young Oh, Shin Ah Kim, So-Yeon Lee, Seung-Hwa Lee, Soo-Jong Hong and Hyunsoo Kim | Summary: Abstract Rationale Exposure to humidifier disinfectants has been linked to an array of pulmonary disorders and diminished […]
Kavli Affiliate: Justus M Kebschull | Authors: Rishi Koneru, Manjari M-G Anant, Hyopil Kim, Julian Cheron and Justus M Kebschull | Summary: The precise dissection of anatomically defined brain regions is the basis of many workflows in neurobiology. Traditionally, brain regions of interest are defined by visual inspection of tissue sections, followed by manual dissection. […]
Kavli Affiliate: Seth Blackshaw | Authors: Kurt Weir, Pin Lyu, Sangeetha Kandoi, Roujin An, Nicole Pannullo, Isabella Palazzo, Jared Tangeman, Jun Shi, Steven DeVries, Dana Merriman, Jiang Qian and Seth Blackshaw | Summary: Evolutionary adaptation to diurnal vision in ground squirrels has led to the development of a cone-dominant retina, in stark contrast to the […]