Kavli Affiliate: Kishore V. Kuchibhotla and Adam S. Charles | Authors: Alejandro A Estrada Berlanga, Gabrielle Kang, Amanda Kwok, Thomas Broggini, Jennifer Lawlor, Kishore Kuchibhotla, David Kleninfeld, Gal Mishne and Adam Charles | Summary: Optical calcium imaging is a powerful tool for recording neural activity across a wide range of spatial scales, from dendrites and […]
Kavli Affiliate: Jeremy Nathans | Authors: Yanshu Wang, Amir Rattner, Zhongming Li, Philip M Smallwood and Jeremy Nathans | Summary: Cajal-Retzius (CR) cells are glutamatergic neurons that transiently populate the most superficial layer of the isocortex and allocortex during development, serving an essential role during both prenatal and early postnatal brain development. Notably, these cells […]
Kavli Affiliate: Laurent Younes and Donald Geman | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Seungmae Seo, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Definition of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. […]
Kavli Affiliate: Keri Martinowich | Authors: Alexa F Iannitelli, Leslie Hassanein, Bernard Mulvey, Harris Blankenship, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Arielle Segal, Steven A Sloan, Keri Martinowich, Katharine E McCann, Joseph D Dougherty, Yoland Smith, Michael J Beckstead and David Weinshenker | Summary: The locus coeruleus (LC), the major source of norepinephrine […]
Kavli Affiliate: Carey Priebe and Joshua Vogelstein | Authors: Qingyang Wang, Nadine Randel, Yijie Yin, Cameron Shand, Amy Strange, Michael Winding, Albert Cardona, Marta Zlatic, Joshua Vogelstein and Carey Priebe | Summary: The emerging electron microscopy connectome datasets provides connectivity maps of the brains at single cell resolution, enabling us to estimate various network statistics, […]
Kavli Affiliate: Xingde Li | Authors: Yongping Chen and Xingde Li | Summary: This study investigates the synthesis of pH-responsive, reversible nanocomposites comprising polystyrene sulfonate (PSS)-coated gold nanorods and poly(allylamine hydrochloride) (PAH)-coated gold nanorods, along with their optical properties. We observed a pH-dependent swelling/shrinking of the nanocomposites and a dramatic red-shift (~ 60 nm) of […]
Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Donald Kramer, Yu Shen, Habin Bea, Margarita Tsapatsis, Jianglu Ping, Vasco Queiroga, Kyu Sang Han, Saurabh Joshi, Casey Grubel, Maria L. Beery, Irina Kusmartseva, Mark A. Atkinson, Ashley L Kiemen and Denis Wirtz | Summary: Nuclear morphology is an indicator of cellular function and disease states, as […]
Kavli Affiliate: Seth Blackshaw | Authors: Leah J Elias, Harrison Khoo, Francois Kroll, Caroline Zhang, Soojung C Hur, Jason Rihel and Seth Blackshaw | Summary: While sleep deprivation broadly disrupts health and well-being, the neural and molecular mechanisms that signal increased sleep pressure remain poorly understood. A key obstacle to progress is the fact that […]
Kavli Affiliate: Denis Wirtz | Authors: pei-hsun wu, Denis Wirtz, Tiffany Chu, yeongseo lim and Yufei Sun | Summary: Cell migration plays a key role in normal developmental programs and in disease, including immune responses, tissue repair, and metastasis. Unlike other cell functions, such as proliferation which can be studied using high-throughput assays, cell migration […]
Kavli Affiliate: Patrick Kanold | Authors: Kate Maximov and Patrick O. Kanold | Summary: Presbycusis, or age-related hearing loss, is caused by changes in both the peripheral and the central auditory system. Many of the peripheral structures that degrade with age have been identified and characterized, but there is still a dearth of information pertaining […]