Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

Kavli Affiliate: Alex Kolodkin | Authors: Eleftheria Koropouli, Qiang Wang, Rebeca Mejias-Estevez, Randal Hand, Tao Wang, David D Ginty and Alex L Kolodkin | Summary: ABSTRACT Secreted semaphorin 3F (Sema3F) and semaphorin 3A (Sema3A) exhibit remarkably distinct effects on deep layer excitatory cortical pyramidal neurons; Sema3F mediates dendritic spine pruning, whereas Sema3A promotes the elaboration […]


Continue.. Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

MLL1 regulates cytokine-driven cell migration and metastasis

Kavli Affiliate: Denis Wirtz | Authors: Praful R Nair, Ludmila Danilova, Estibaliz Gómez-de-Mariscal, Dongjoo Kim, Rong Fan, Arrate Munoz-Barrutia, Elana J Fertig and Denis Wirtz | Summary: Abstract Cell migration is a critical requirement for cancer metastasis. Cytokine production and its role in cancer cell migration have been traditionally associated with immune cells in the […]


Continue.. MLL1 regulates cytokine-driven cell migration and metastasis

A machine learning based approach towards high-dimensional mediation analysis

Kavli Affiliate: Brian Caffo, Martin Lindquist | Authors: Tanmay Nath, Brian Caffo, Tor Wager and Martin Lindquist | Summary: Abstract Mediation analysis is used to investigate the role of intermediate variables (mediators) that lie in the path between an exposure and an outcome variable. While significant research has focused on developing methods for assessing the […]


Continue.. A machine learning based approach towards high-dimensional mediation analysis

Pantr2, a trans-acting lncRNA, modulates the differentiation potential of neural progenitors in vivo

Kavli Affiliate: Seth Blackshaw, Loyal Goff | Authors: Jonathan J Augustin, Saki Takayangi, Thanh Hoang, Briana Winer, Seth Blackshaw and Loyal A Goff | Summary: Abstract Ablation of the long non-coding RNA (lncRNA) Pantr2 re- sults in microcephaly in a knockout murine model of cor- ticogenesis, however, the precise mechanisms used are un- known. We […]


Continue.. Pantr2, a trans-acting lncRNA, modulates the differentiation potential of neural progenitors in vivo

Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys

Kavli Affiliate: Jeremiah Cohen | Authors: Jae Hyung Woo, Claudia G Aguirre, Bilal A Bari, Ken-Ichiro Tsutsui, Fabian Grabenhorst, Jeremiah Y Cohen, Wolfram Schultz, Alicia Izquierdo and Alireza Soltani | Summary: Abstract Despite being unpredictable and uncertain, reward environments often exhibit certain regularities, and animals navigating these environments try to detect and utilize such regularities […]


Continue.. Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys

MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Kavli Affiliate: Dwight Bergles | Authors: Em P Harrington, Riley B Catenacci, Matthew D Smith, Dongeun Heo, Cecilia E Miller, Keya R Meyers, Jenna Glatzer, Dwight E Bergles and Peter A Calabresi | Summary: Abstract Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown […]


Continue.. MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Feasibility Analyses and Experimental Confirmation of Dove Prism Based Dual-fiberscope Rotary Joint

Kavli Affiliate: Xingde Li | Authors: Yuehan Liu, Hyeon-Cheol Park, Haolin Zhang and Xingde Li | Summary: Abstract Two-photon fluorescence microscopy has enjoyed its wide adoption in neuroscience. Head-mounted miniaturized fiberscopes offered an exciting opportunity for enabling neural imaging in freely-behaving animals with high 3D resolution. Here we propose a dual-fiberscope rotary joint based on […]


Continue.. Feasibility Analyses and Experimental Confirmation of Dove Prism Based Dual-fiberscope Rotary Joint

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

Kavli Affiliate: Michael Miller | Authors: Han Zhu, Gaowei Wang, Kim-Vy Nguyen-Ngoc, Dongsu Kim, Michael Miller, Georgina Goss, Jenna Kovsky, Austin R Harrington, Diane Saunders, Rebecca Melton, Alvin C Powers, Sebastian Preissl, Francesca M Spagnoli, Kyle J Gaulton and Maike Sander | Summary: Abstract Pancreatic islet cells derived from human pluripotent stem cells hold great […]


Continue.. Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

Olfactory neuronal cells: biopsied surrogates for neurons in the brain

Kavli Affiliate: Donald Geman, Laurent Younes | Authors: Kun Yang, Koko Ishizuka, Zui Narita, Yukiko Y Lema, Siwei Zhang, Jubao Duan, Laurent Younes, Donald Geman, Andrew P Lane and Akira Sawa | Summary: ABSTRACT Biopsy is an essential procedure of clinical medicine in which we obtain tissues and cells that are supposed to directly reflect […]


Continue.. Olfactory neuronal cells: biopsied surrogates for neurons in the brain

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

Kavli Affiliate: Michael Miller | Authors: MoTrPAC Study Group, David Amar, Nicole R. Gay, Pierre M. Jean Beltran, Joshua N. Adkins, Jose J. Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Nasim Bararpour, Charles Burant, Clary Clish, Gary Cutter, Surendra Dasari, Courtney Dennis, Charles R. Evans, Facundo M. Fernández, David Gaul, Yongchao Ge, Robert Gerszten, […]


Continue.. Temporal dynamics of the multi-omic response to endurance exercise training across tissues