Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Maxime Fouyssac, Yvan M Vachez, Yifeng Cheng, Thibault Dufourd, Carole Carcenac, sabrina Boulet, Patricia H Janak, Marc Savasta, David Belin and Sebastien Carnicella | Summary: Impulse control disorders (ICDs), a wide spectrum of maladaptive behavior which includes pathological gambling, hypersexuality and compulsive buying, have been recently suggested […]


Continue.. Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks

Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection

Kavli Affiliate: Michael Beer | Authors: Jessica D. Resnick, Jo L. Wilson, Eddy Anaya, Abigail Conte, Maggie Li, William Zhong, Michael A. Beer and Andrew Pekosz | Summary: Primary differentiated human epithelial cell cultures have been widely used by researchers to study viral fitness and virus-host interactions, especially during the COVID19 pandemic. These cultures recapitulate […]


Continue.. Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection

Batch Effects are Causal Effects: Applications in Human Connectomics

Kavli Affiliate: Brian Caffo, Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Batch effects, undesirable sources of variance across multiple experiments, present significant challenges for scientific and clinical discoveries. Specifically, batch effects […]


Continue.. Batch Effects are Causal Effects: Applications in Human Connectomics

Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks

Kavli Affiliate: Adam S. Charles | Authors: Ahmed El Hady, Daniel Y Takahashi, Ruolan Sun, Oluwateniola Akinwale, Tyler Boyd-Meredith, Yisi Zhang, Adam Charles and Carlos Brody | Summary: Functional ultrasound imaging (fUS) is an emerging imaging technique that indirectly measures neural activity via changes in blood volume. To date it has not been used to […]


Continue.. Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks

Hallucination proneness alters sensory feedback processing in self-voice production

Kavli Affiliate: David Linden | Authors: Suvarnalata Xanthate Duggirala, Michael Schwartze, Lisa K Goller, David E.J. Linden, Ana Pinheiro and Sonja A Kotz | Summary: Background: Sensory suppression occurs when hearing ones self-generated voice, as opposed to passively listening to ones own voice. Quality changes of sensory feedback to the self-generated voice can increase attentional […]


Continue.. Hallucination proneness alters sensory feedback processing in self-voice production

Mechano-induced homotypic patterned domain formation by monocytes

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Jingyi Zhu, Yufei Wu, Ashley Kiemen, Sean Sun and Denis Wirtz | Summary: Matrix stiffness and corresponding mechano-signaling play indispensable roles in cellular phenotypes and functions. How tissue stiffness influences the behavior of monocytes, a major circulating leukocyte of the innate system, and how it may promote […]


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A Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC)

Kavli Affiliate: Wesley Thompson | Authors: Rong Zablocki, Bohan Xu, Chun-Chieh Fan and Wesley K. Thompson | Summary: Here we present a development of the novel Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC) model. BRAINIAC allows for both estimation of total variance explained by all features for a given cognitive phenotype, as well […]


Continue.. A Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC)

Microglial cannabinoid receptor type1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication

Kavli Affiliate: Solange Brown | Authors: Yuto Hasegawa, Juhyun Kim, Gianluca Ursini, Yan Jouroukhin, Xiaolei Zhu, Yu Miyahara, Feiyi Xiong, Samskruthi Madireddy, Mizuho Obayashi, Beat Lutz, Akira Sawa, Solange P Brown, Mikhail V Pletnikov and Atsushi Kamiya | Summary: Adolescent cannabis use increases the risk for cognitive impairments and psychiatric disorders. Cannabinoid receptor type 1 […]


Continue.. Microglial cannabinoid receptor type1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication

Exuberant de novo dendritic spine growth in mature neurons

Kavli Affiliate: Hey-Kyoung Lee | Authors: Sarah Kruessel, Ishana Deb, Seungkyu Son, Gabrielle Ewall, Minhyeok Chang, Hey-Kyoung Lee, Won Do Heo and Hyung-Bae Kwon | Summary: Dendritic spines are structural correlates of excitatory synapses maintaining stable synaptic communications. However, this strong spine-synapse relationship was mainly characterized in excitatory pyramidal neurons (PyNs), raising a possibility that […]


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Calcium-permeable AMPA receptors govern PV neuron feature selectivity

Kavli Affiliate: Dwight Bergles, Seth Blackshaw | Authors: Ingie Hong, Juhyun Kim, Thomas Hainmueller, Dong Won Kim, Richard C. Johnson, Soo Hyun Park, Nathachit Limjunyawong, Zhuonan Yang, David Cheon, Taeyoung Hwang, Amit Agarwal, Thibault Cholvin, Fenna M. Krienen, Steven A. McCarroll, Xinzhong Dong, David A. Leopold, Seth Blackshaw, Dwight E. Bergles, Marlene Bartos, Solange P. […]


Continue.. Calcium-permeable AMPA receptors govern PV neuron feature selectivity