The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

Kavli Affiliate: Keri Martinowich | Authors: Lukas M Weber, Heena R Divecha, Matthew N Tran, Sang Ho Kwon, Abby Spangler, Kelsey D Montgomery, Madhavi Tippani, Rahul Bharadwaj, Joel E Kleinman, Stephanie C Page, Thomas M Hyde, Leonardo Collado-Torres, Kristen R Maynard, Keri Martinowich and Stephanie C Hicks | Summary: Norepinephrine (NE) neurons in the locus […]


Continue.. The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

Costs of resistance limit the effectiveness of cooperation enforcement

Kavli Affiliate: Michael Miller | Authors: Michael E Miller, Susan Sidell and Elizabeth A Ostrowski | Summary: Cooperative groups are susceptible to invasion by cheaters that reap the benefits but fail to pay the costs. Both theory and experimental work have shown that cheating can select for counter-adaptations to resist cheating. But then why is […]


Continue.. Costs of resistance limit the effectiveness of cooperation enforcement

Effort cost of reaching prompts vigor reduction in older adults

Kavli Affiliate: Reza Shadmehr | Authors: Erik M. Summerside, Robert J Courter, Reza Shadmehr and Alaa A. Ahmed | Summary: As people age, they move slower. Is age-related reduction in vigor a reflection of a reduced valuation of reward by the brain, or a consequence of increased effort costs by the muscles? Here, we quantified […]


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African elephants address one another with individually specific calls

Kavli Affiliate: Cynthia F. Moss | Authors: Michael A Pardo, Kurt Fristrup, David S Lolchuragi, Joyce Poole, Petter Granli, Cynthia Moss, Iain Douglas-Hamilton and George Wittemyer | Summary: Personal names are a universal feature of human language, yet few analogs exist in other species. While dolphins and parrots address conspecifics by imitating the calls of […]


Continue.. African elephants address one another with individually specific calls

Alignment of spatial transcriptomics data using diffeomorphic metric mapping

Kavli Affiliate: Justus M Kebschull, Michael Miller, Jean Fan | Authors: Kalen Clifton, Manjari Anant, Gohta Aihara, Lyla Atta, Osagie K Aimiuwu, Justus M Kebschull, Michael I Miller, Daniel Tward and Jean Fan | Summary: Spatial transcriptomics (ST) technologies enable high throughput gene expression characterization within thin tissue sections. However, comparing spatial observations across sections, […]


Continue.. Alignment of spatial transcriptomics data using diffeomorphic metric mapping

Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

Kavli Affiliate: Seth Blackshaw | Authors: WPin Lyu, Maria Iribarne, Dmitri Serjanov, Yijie Zhai, Thanh Hoang, Leah J. Campbell, Patrick Boyd, Isabella Palazzo, Mikiko Nagashima, Nicholas J. Silva, Peter F. HItchcock, Jiang Qian, David R. Hyde and Seth Blackshaw | Summary: Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes. This […]


Continue.. Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

A semi-automated method for quantifying optokinetic reflex tracking acuity

Kavli Affiliate: Alex Kolodkin | Authors: James Kenneth Kiraly, Scott C Harris, Timour Al-Khindi, Felice Dunn and Alex L Kolodkin | Summary: The study of murine behavioral responses to visual stimuli is a key component of understanding mammalian visual circuitry. One notable response is the optokinetic reflex (OKR), a highly conserved innate behavior necessary for […]


Continue.. A semi-automated method for quantifying optokinetic reflex tracking acuity

SynGAP regulates synaptic plasticity and cognition independent of its catalytic activity

Kavli Affiliate: Richard Huganir | Authors: Yoichi Araki, Kacey E Rajkovich, Elizabeth E Gerber, Timothy R Gamache, Richard C Johnson, Thanh Hai Tran, Bian Liu, Ingie Hong, Alfredo Kirkwood and Richard L Huganir | Summary: SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. Mutations in SYNGAP1 in […]


Continue.. SynGAP regulates synaptic plasticity and cognition independent of its catalytic activity

Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Maxime Fouyssac, Yvan M Vachez, Yifeng Cheng, Thibault Dufourd, Carole Carcenac, sabrina Boulet, Patricia H Janak, Marc Savasta, David Belin and Sebastien Carnicella | Summary: Impulse control disorders (ICDs), a wide spectrum of maladaptive behavior which includes pathological gambling, hypersexuality and compulsive buying, have been recently suggested […]


Continue.. Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks

Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection

Kavli Affiliate: Michael Beer | Authors: Jessica D. Resnick, Jo L. Wilson, Eddy Anaya, Abigail Conte, Maggie Li, William Zhong, Michael A. Beer and Andrew Pekosz | Summary: Primary differentiated human epithelial cell cultures have been widely used by researchers to study viral fitness and virus-host interactions, especially during the COVID19 pandemic. These cultures recapitulate […]


Continue.. Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection