Effective Multiple Scattering Correction for Accurate Quantitative OCT

Kavli Affiliate: Xingde Li | Authors: Cheng-Yu Lee and Xingde Li | Summary: We present an effective approach to compensate for multiple scattering effects in Quantitative Optical Coherence Tomography (qOCT) imaging, with the goal of accurately extracting tissue attenuation coefficients, which is crucial for precise clinical diagnosis. In clinical practice, especially for intra-operative imaging, an […]


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Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders

Kavli Affiliate: Michael Miller | Authors: Zinan Zhou, Lovelace J Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, Kisong Kim, Mingyun Bae, Diane D Shao, Bezawit Sahile, Michael B Miller, August Yue Huang, Peter J Park, Clotilde Lagier-Tourenne, Eunjung Alice Lee and Christopher A Walsh | Summary: Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s […]


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Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy

Kavli Affiliate: Michael Miller | Authors: Guanlan Dong, Chanthia C Ma, Shulin Mao, Samuel M Naik, Katherine Sun-Mi Brown, Gannon A McDonough, Junho Kim, Samantha L Kirkham, Jonathan Cherry, Madeline Uretsky, Elizabeth Spurlock, Ann McKee, August Yue Huang, Michael B Miller, Eunjung Alice Lee and Christopher A Walsh | Summary: Chronic traumatic encephalopathy (CTE) is […]


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Effectiveness of Digital Dispersion Compensation in OCT

Kavli Affiliate: Xingde Li | Authors: Fengquan Liu and Xingde Li | Summary: Dispersion mismatch in optical coherence tomography (OCT) is typically addressed through either physical or digital compensation. In this study, we investigate the impact of dispersion on OCT detection sensitivity and compare the effectiveness of physical and digital compensation across varying degrees of […]


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Development of an image-guided non-vitrectomy subretinal access approach for trans-scleral cell and gene therapy delivery

Kavli Affiliate: Jin Kang | Authors: Mandeep S Singh, Shoujing Guo, Christopher B Toomey, Minda M McNally, Sarah Harris-Bookman, Kang V Li, Dzhalal Agakishiev, Shuwen Wei, Soohyun Lee, Kathleen Perrino, Kevin C Wolfe and Jin Kang | Summary: Purpose Regenerative therapies for retinal diseases include cell and gene therapy modalities that are targeted to the […]


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Focus-Tunable Two-Photon Fiberscope Enabling in vivo Imaging at Selected Depths

Kavli Affiliate: Xingde Li | Authors: Yuehan Liu, Jiayun Laurie Huang and Xingde Li | Summary: Miniaturized two-photon imaging devices enable real-time in vivo and in situ imaging at subcellular resolution, highly valuable for clinical applications and basic research (such as neuroscience). However, achieving high-quality volumetric imaging at varying depths remains challenging. In this study, […]


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Neuromodulation in neural organoids with shell MEAs

Kavli Affiliate: Brian Caffo | Authors: Chris Acha, Derosh George, Lauren C. Diaz, Ziwei Ouyang, Dowlette-Mary M. Alam El Din, Hrishikesh Surlekar, Babak Moghadas, Pratyush Sai R. Rayasam, Yu-Chiao Lai, Lena Smirnova, Brian S. Caffo, Erik C. Johnson and David H. Gracias | Summary: Neural organoids (NOs) have emerged as important tissue engineering models for […]


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No Disconnection Syndrome after Near-Complete Callosotomy

Kavli Affiliate: Michael Miller | Authors: Selin Bekir, Johanna L. Hopf, Theresa Paul, Valerie M. Wiemer, Tyler Santander, Henri E. Skinner, Anna Rada, Friedrich G. Woermann, Thilo Kalbhenn, Barry Giesbrecht, Christian G. Bien, Olaf Sporns, Michael S. Gazzaniga, Lukas J. Volz and Michael B. Miller | Summary: Much of the sensory-motor processing in the human […]


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Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression

Kavli Affiliate: Michael Miller | Authors: Rebecca Melton, Sara Jimenez, Weston Elison, Luca Tucciarone, Abigail Howell, Gaowei Wang, Denise Berti, Elisha Beebe, Michael Miller, Chun Zeng, Kennedy Vanderstel, Katha Korgaonkar, Ruth Elgamal, Hannah Mummey, Josh Chiou, Emily Griffin, Irina Kusmartseva, Mark A. Atkinson, Sebastian Preissl, Fabian Theis, Maike Sander and Kyle J Gaulton | Summary: […]


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Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers

Kavli Affiliate: Michael Miller | Authors: Tyler Santander, Selin Bekir, Theresa Paul, Jessica M Simonson, Valerie M Wiemer, Henri Etel Skinner, Johanna L Hopf, Anna Rada, Friedrich G Woermann, Thilo Kalbhenn, Barry Giesbrecht, Christian G Bien, Olaf Sporns, Michael S Gazzaniga, Lukas J Volz and Michael B Miller | Summary: The dynamic integration of the […]


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