Overexpression of Meis factors in late-stage retinal progenitors yields complex effects on temporal patterning and neurogenesis.

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Seth Blackshaw | Authors: Patrick Leavey, Lizhi Jiang, Nicole Pannullo, Clayton Santiago and Seth Blackshaw | Summary: The vertebrate retina serves as a model for studying neurogenesis and cell fate specification, with retinal progenitor cells following a tightly regulated temporal sequence to generate distinct cell types. Meis1 and Meis2 are transcription factors implicated […]


Continue.. Overexpression of Meis factors in late-stage retinal progenitors yields complex effects on temporal patterning and neurogenesis.

Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Michael Miller | Authors: Tyler Santander, Selin Bekir, Theresa Paul, Jessica M Simonson, Valerie M Wiemer, Henri Etel Skinner, Johanna L Hopf, Anna Rada, Friedrich G Woermann, Thilo Kalbhenn, Barry Giesbrecht, Christian G Bien, Olaf Sporns, Michael S Gazzaniga, Lukas J Volz and Michael B Miller | Summary: The dynamic integration of the […]


Continue.. Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers

Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Seth Blackshaw | Authors: Selin Bekir, Johanna L. Hopf, Theresa Paul, Valerie M. Wiemer, Tyler Santander, Henri E. Skinner, Anna Rada, Friedrich G. Woermann, Thilo Kalbhenn, Barry Giesbrecht, Christian G. Bien, Olaf Sporns, Michael S. Gazzaniga, Lukas J. Volz and Michael B. Miller | Summary: Evolutionary adaptation to diurnal vision in ground squirrels […]


Continue.. Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

No Disconnection Syndrome after Near-Complete Callosotomy

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Michael Miller | Authors: Selin Bekir, Johanna L. Hopf, Theresa Paul, Valerie M. Wiemer, Tyler Santander, Henri E. Skinner, Anna Rada, Friedrich G. Woermann, Thilo Kalbhenn, Barry Giesbrecht, Christian G. Bien, Olaf Sporns, Michael S. Gazzaniga, Lukas J. Volz and Michael B. Miller | Summary: Sensorimotor processing in the human brain is largely […]


Continue.. No Disconnection Syndrome after Near-Complete Callosotomy

Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Keri Martinowich | Authors: Bernard Mulvey, Yi Wang, Heena R Divecha, Svitlana V Bach, Kelsey D Montgomery, Sophia Cinquemani, Atharv Chandra, Yufeng Du, Ryan A Miller, Joel E Kleinman, Stephanie Cerceo Page, Thomas M Hyde, Keri Martinowich, Stephanie C Hicks, Kasper D Hansen and Kristen R Maynard | Summary: The hypothalamus contains multiple […]


Continue.. Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus

Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Maria Luisa Amaral, Sainath Mamde, Michael Miller, Xiaomeng Hou, Jessica Arzavala, Julia Osteen, Elizabeth Walker Smoot, Qian Yang, Emily Eisner, Qiurui Zeng, Cindy Tatiana Baez-Becerra, Jacqueline Olness, Joseph Colin Kern, Jonathan Rink, Nicholas Johnson, Ariana Barcoma, Silvia Cho, Stella Cao, Nora Emerson, Jasper Lee, Jackson Willier, Timothy Loe, Henry […]


Continue.. Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Decomposed Linear Dynamical Systems (dLDS) models reveal context-dependent dynamic connectivity in C. elegans

Posted by dbos Hopkins

Kavli Affiliate: Adam S. Charles | Authors: Eva Yezerets, Noga Mudrik and Adam Charles | Summary: Mounting empirical evidence indicates that neural “tuning” can be highly variable within an individual across time and especially across individuals. Furthermore, modulatory effects can change the relationship between neurons in the brain as a function of behavioral or other […]


Continue.. Decomposed Linear Dynamical Systems (dLDS) models reveal context-dependent dynamic connectivity in C. elegans

Fast and accessible morphology-free functional fluorescence imaging analysis

Posted by dbos Hopkins

Kavli Affiliate: Kishore V. Kuchibhotla and Adam S. Charles | Authors: Alejandro A Estrada Berlanga, Gabrielle Kang, Amanda Kwok, Thomas Broggini, Jennifer Lawlor, Kishore Kuchibhotla, David Kleninfeld, Gal Mishne and Adam Charles | Summary: Optical calcium imaging is a powerful tool for recording neural activity across a wide range of spatial scales, from dendrites and […]


Continue.. Fast and accessible morphology-free functional fluorescence imaging analysis

Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

Posted by dbos Hopkins

Kavli Affiliate: Jeremy Nathans | Authors: Yanshu Wang, Amir Rattner, Zhongming Li, Philip M Smallwood and Jeremy Nathans | Summary: Cajal-Retzius (CR) cells are glutamatergic neurons that transiently populate the most superficial layer of the isocortex and allocortex during development, serving an essential role during both prenatal and early postnatal brain development. Notably, these cells […]


Continue.. Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity

Posted by dbos Hopkins

Kavli Affiliate: Laurent Younes and Donald Geman | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Seungmae Seo, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Definition of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. […]


Continue.. CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity