Kavli Affiliate: Shreesh P. Mysore | Authors: Huixin Huang, Garima Shah, Hita Adwanikar and Shreesh Mysore | Summary: Investigations into the neural basis of behavior have recently employed fluorescence imaging of calcium dynamics in a variety of brain areas to measure neural responses. However, across studies, diverse and seemingly subjective methodological choices have been made […]

Kavli Affiliate: Loyal Goff | Authors: Yi Wang, Kyla Woyshner, Chaichontat Sriworarat, Genevieve Stein-O’Brien, Loyal A Goff and Kasper D Hansen | Summary: Analyzing multi-sample spatial transcriptomics data requires accounting for biological variation. We present multi-sample non-negative spatial factorization (mNSF), an alignment-free framework extending single-sample spatial factorization (NSF) to multi-sample datasets. mNSF incorporates sample-specific spatial […]

Kavli Affiliate: Jean Fan | Authors: Dee Velazquez and Jean Fan | Summary: Summary: Displaying proportional data across many spatially resolved coordinates is a challenging but important data visualization task, particularly for spatially resolved transcriptomics data. Scatter pie plots are one type of commonly used data visualization for such data but present perceptual challenges that […]

Kavli Affiliate: Patricia Janak | Authors: Emma Chaloux-Pinette, Maricela Vela Mirelez-Prince, Samantha Soto, Kirtana Ananth, Xiao Tong, Vanessa Silva, Daniela Rodriguez and Patricia H Janak | Summary: The central nucleus of the amygdala plays a key role in many aspects of substance use disorders, in particular biasing behaviors toward one drug or natural reward over […]

Kavli Affiliate: Sridevi Sarma | Authors: Daniel Ehrens, Fadi Aeed, Yara Otor, Vivek Charu, Babak Razavi, Sridevi V Sarma, Yitzhak Schiller and Peter A Tass | Summary: Epilepsy, a neurological disorder characterized by recurrent seizures, profoundly impacts individuals worldwide. Various electrical stimulation protocols have been investigated to mitigate epileptic seizures, among which Coordinated Reset (CR) […]

Kavli Affiliate: Michael Miller | Authors: Paul J Laurienti, Stephen B Kritchevsky, Robert G Lyday, Michael E Miller, Samuel N Lockhart, Melissa M Rundle, Christina E Hugenschmidt, Jonathan H Burdette, Heather M Shappell, Haiying Chen, Laura D Baker, Blake R Neyland and Roee Holtzer | Summary: Cognitive and physical function are interrelated in aging co-occurring […]

Kavli Affiliate: Keri Martinowich | Authors: Daianna Gonzalez-Padilla, Nicholas J. Eagles, Marisol Cano, Geo Pertea, Andrew E. Jaffe, Kristen R. Maynard, Dana B. Hancock, James T. Handa, Keri Martinowich and Leonardo Collado-Torres | Summary: Maternal smoking during pregnancy (MSDP) is associated with significant cognitive and behavioral effects on offspring. While neurodevelopmental outcomes have been studied […]

Kavli Affiliate: Laurent Younes and Michael Miller | Authors: Kaitlin Stouffer, Xiaoyin Chen, Hongkui Zeng, Benjamin Charlier, Laurent Younes, Alain Trouve and Michael I Miller | Summary: Advancements in imaging and molecular techniques enable the collection of subcellular-scale data. Diversity in measured features, resolution, and physical scope of capture across technologies and experimental protocols pose […]

Kavli Affiliate: Solange Brown, Loyal Goff, and Patrick Kanold | Authors: Su-Jeong Kim, Travis A. Babola, Kihwan Lee, Chanel J. Matney, Alina C. Spiegel, Michael H. Liew, Eva M. Schulteis, Austin E. Coye, Mikhail Proskurin, Hyunwook Kang, Julia A. Kim, Maxime Chevee, Kiwoong Lee, Patrick O. Kanold, Loyal A. Goff, Juhyun Kim and Solange P […]

Kavli Affiliate: Laurent Younes | Authors: An Wang, Stephanie C Hicks, Donald Geman and Laurent Younes | Summary: The selection of marker gene panels is critical for capturing the cellular and spatial heterogeneity in the expanding atlases of single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics data. Most current approaches to marker gene selection operate in […]