Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Jeremy Nathans | Authors: Yanshu Wang, Amir Rattner, Zhongming Li, Philip M Smallwood and Jeremy Nathans | Summary: Cajal-Retzius (CR) cells are glutamatergic neurons that transiently populate the most superficial layer of the isocortex and allocortex during development, serving an essential role during both prenatal and early postnatal brain development. Notably, these cells […]


Continue.. Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Laurent Younes and Donald Geman | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Seungmae Seo, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Definition of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. […]


Continue.. CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Keri Martinowich | Authors: Alexa F Iannitelli, Leslie Hassanein, Bernard Mulvey, Harris Blankenship, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Arielle Segal, Steven A Sloan, Keri Martinowich, Katharine E McCann, Joseph D Dougherty, Yoland Smith, Michael J Beckstead and David Weinshenker | Summary: The locus coeruleus (LC), the major source of norepinephrine […]


Continue.. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Measuring the functional complexity of nanoscale connectomes: polarity matters

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Carey Priebe and Joshua Vogelstein | Authors: Qingyang Wang, Nadine Randel, Yijie Yin, Cameron Shand, Amy Strange, Michael Winding, Albert Cardona, Marta Zlatic, Joshua Vogelstein and Carey Priebe | Summary: The emerging electron microscopy connectome datasets provides connectivity maps of the brains at single cell resolution, enabling us to estimate various network statistics, […]


Continue.. Measuring the functional complexity of nanoscale connectomes: polarity matters

pH-Sensitive Optical Nanocomposites Using Polymer-Coated Gold Nanorods

Posted by klaurent Hopkins

Kavli Affiliate: Xingde Li | Authors: Yongping Chen and Xingde Li | Summary: This study investigates the synthesis of pH-responsive, reversible nanocomposites comprising polystyrene sulfonate (PSS)-coated gold nanorods and poly(allylamine hydrochloride) (PAH)-coated gold nanorods, along with their optical properties. We observed a pH-dependent swelling/shrinking of the nanocomposites and a dramatic red-shift (~ 60 nm) of […]


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Integration of nuclear morphology and 3D imaging to profile cellular neighborhoods

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Donald Kramer, Yu Shen, Habin Bea, Margarita Tsapatsis, Jianglu Ping, Vasco Queiroga, Kyu Sang Han, Saurabh Joshi, Casey Grubel, Maria L. Beery, Irina Kusmartseva, Mark A. Atkinson, Ashley L Kiemen and Denis Wirtz | Summary: Nuclear morphology is an indicator of cellular function and disease states, as […]


Continue.. Integration of nuclear morphology and 3D imaging to profile cellular neighborhoods

JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Leah J Elias, Harrison Khoo, Francois Kroll, Caroline Zhang, Soojung C Hur, Jason Rihel and Seth Blackshaw | Summary: While sleep deprivation broadly disrupts health and well-being, the neural and molecular mechanisms that signal increased sleep pressure remain poorly understood. A key obstacle to progress is the fact that […]


Continue.. JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish

Accelerated Discovery of Cell Migration Regulators Using Label-Free Deep Learning-Based Automated Tracking

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: pei-hsun wu, Denis Wirtz, Tiffany Chu, yeongseo lim and Yufei Sun | Summary: Cell migration plays a key role in normal developmental programs and in disease, including immune responses, tissue repair, and metastasis. Unlike other cell functions, such as proliferation which can be studied using high-throughput assays, cell migration […]


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Aging reduces excitatory bandwidth, alters spectral tuning curve diversity, and reduces sideband inhibition in L2/3 of primary auditory cortex

Posted by klaurent Hopkins

Kavli Affiliate: Patrick Kanold | Authors: Kate Maximov and Patrick O. Kanold | Summary: Presbycusis, or age-related hearing loss, is caused by changes in both the peripheral and the central auditory system. Many of the peripheral structures that degrade with age have been identified and characterized, but there is still a dearth of information pertaining […]


Continue.. Aging reduces excitatory bandwidth, alters spectral tuning curve diversity, and reduces sideband inhibition in L2/3 of primary auditory cortex

Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: pei-hsun wu, Denis Wirtz, Tiffany Chu, yeongseo lim and Yufei Sun | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe binding to […]


Continue.. Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling