3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Vasco Queiroga, Yajuan Li, Alfredo Hernandez, Ashleigh Crawford, Xiaoyu Qin, Mei Zhong, Margarita Tsapatsis, Saurabh Joshi, Donald Kramer, Oliver Nizet, Habin Bea, Yuhan Li, Shuo Qin, Robert O Flynn, Mingder Yang, Britanny Pratt, Fan Wu, Paul Gensbigler, Max Blecher, Pei-Hsun Wu, Luciane Tsukamoto Kagohara, Ie Ming Shih, […]


Continue.. 3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across Tauopathies

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Michael Miller | Authors: Lei Liu, Yin Zheng, Luke Slominski, Qimin Quan, Adriana Saba, Jean-Pierre Bellier, Han-Bin Yoo, Andrea Roman, Elizabeth L Hennessey, Samadhi Wijethunga, Elif Lara Okyay, Michael B Miller, Hyun-Sik Yang, Dennis J Selkoe and Jasmeer Chhatwal | Summary: Background Alternative splicing of the MAPT gene produces distinct tau isoforms in […]


Continue.. CNS-Tau Specific Antibodies Illuminate Disease Signatures Across Tauopathies

Altered NPTX2 dynamics associated with impaired cognitive aging

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Michela Gallagher | Authors: Rebecca P. Haberman, Ana Delgado, Meifang Xiao, Ming Teng Koh, Ashley A Becker, Shiyu Ji, Paul F Worley, Michela Gallagher and Audrey E. Branch | Summary: Changes in synaptic integrity and neural activity homeostasis are hallmarks of brain aging and are closely tied to cognitive outcomes. Yet, defining their […]


Continue.. Altered NPTX2 dynamics associated with impaired cognitive aging

Separating the control of moving and holding still in post-stroke arm paresis

Posted by klaurent Hopkins, This Week: Neuroscience

Kavli Affiliate: Reza Shadmehr | Authors: Alkis M. Hadjiosif, Kahori Kita, Scott T. Albert, Robert A. Scheidt, Reza Shadmehr and John W. Krakauer | Summary: Moving and holding still have been posited to be under separate control regimes for both eye and arm movements. The paretic arm after stroke is notable for abnormalities both at […]


Continue.. Separating the control of moving and holding still in post-stroke arm paresis

Single-cell long-read sequencing of the experience-induced transcriptome

Posted by dbos Hopkins

Kavli Affiliate: Richard Huganir | Authors: Sheridan Cavalier, Paul W Hook, Richard L. Huganir and Winston Timp | Summary: Neural activity drives transcriptional events that are critical for learning. Activity-induced transcript isoform expression and alternative splicing are cell-type specific events typically obscured by sequencing approaches that restrict read length. We combined single-cell transcriptomics with Nanopore […]


Continue.. Single-cell long-read sequencing of the experience-induced transcriptome

Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging.

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Pin Lyu, Isabella Palazzo, yang jin, Leah Campbell, Clayton Santiago, Rogger Carmen-Orzoco, Thanh Hoang, Jared Tangeman, Alexander Park, Shawn Yang, Jianming Shao, Rui Chen, David Hyde, Jiang Qian and Seth Blackshaw | Summary: Biological age is a major risk factor in the development of common degenerative retinal diseases such […]


Continue.. Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging.

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Jorge Alberto Miranda-Barrientos, Suhaas Adiraju, Jason J Rehg, Michael S Totty, Henry Hallock, Ye Li, Greggory Carr and Keri Martinowich | Summary: Sustained attention, the ability to focus on a stimulus or task over extended periods, is crucial for higher level cognition, and is impaired across multiple neuropsychiatric and […]


Continue.. Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Prashanthi Ravichandran, Svitlana V. Bach, Robert A. Phillips III, Madeline R. Valentine, Nicholas J. Eagles, Yufeng Du, Ishbel Del Rosario, Ryan A. Miller, Heena R. Divecha, Madhavi Tippani, Kelsey D. Montgomery, Joel E. Kleinman, Shizhong Han, Stephanie Cerceo Page III, Thomas M. Hyde, Leonardo Collado Torres, Alexis Battle, Keri […]


Continue.. Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens

Impact of Data Quality on Deep Learning Prediction of Spatial Transcriptomics from Histology Images

Posted by dbos Hopkins

Kavli Affiliate: Jean Fan | Authors: Caleb Hallinan, Calixto-Hope G Lucas, Jr. and Jean Fan | Summary: Abstract Spatial transcriptomics technologies enable high-throughput quantification of gene expression at specific locations across tissue sections, facilitating insights into the spatial organization of biological processes. However, high costs associated with these technologies have motivated the development of deep […]


Continue.. Impact of Data Quality on Deep Learning Prediction of Spatial Transcriptomics from Histology Images

Biomarker Discovery via Integrative Multi-omics for Children exposed to Humidifier Disinfectant

Posted by dbos Hopkins

Kavli Affiliate: Jin Kang | Authors: Jaeho Ji, Ahrum Son, Mi-Jin Kang, Jeonghun Yeom, Hyun Ju Yoo, Kwoneel Kim, Jeong-Hyun Kim, Hea Young Oh, Shin Ah Kim, So-Yeon Lee, Seung-Hwa Lee, Soo-Jong Hong and Hyunsoo Kim | Summary: Abstract Rationale Exposure to humidifier disinfectants has been linked to an array of pulmonary disorders and diminished […]


Continue.. Biomarker Discovery via Integrative Multi-omics for Children exposed to Humidifier Disinfectant