Precise Extraction of Neural Motifs Reveals Multiscale, Parallel Encoding Schemes in Auditory Cortex

Kavli Affiliate: Adam S. Charles and Patrick Kanold | Authors: Liang Xiang, Mingxuan Wang, Patrick O. Kanold and Adam Charles | Summary: Neural population activity is often stereotyped into recurring activity patterns, i.e., neural motifs, which can be seen as the fundamental building blocks in sensory processing and cognition. In this work we study the […]


Continue.. Precise Extraction of Neural Motifs Reveals Multiscale, Parallel Encoding Schemes in Auditory Cortex

Sensorimotor dynamics in the superior colliculus of the echolocating bat

Kavli Affiliate: Cynthia F. Moss | Authors: Gowri Somasekhar, Ninad B Kothari, Cynthia F Moss and Melville Wohlgemuth | Summary: To successfully execute natural tasks, animals must continuously monitor and integrate dynamic sensory information to guide behavior. While this process – known as active sensing – is fundamental to goal-directed behavior, the mechanisms by which […]


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Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

Kavli Affiliate: Patrick Kanold | Authors: HiJee Kang, Travis Babola and Patrick O Kanold | Summary: Sensory information is represented by small neuronal ensembles in sensory cortices. Neuronal activity shows high trial-by-trial variability in that repeated presentation of the same stimulus, e. g., multiple presentations of the same sound activate differing ensembles in the auditory […]


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Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed

Kavli Affiliate: Adam S. Charles | Authors: Kyle A. Johnsen, Nathanael A. Cruzado, Zachary C. Menard, Adam A. Willats, Adam S. Charles, Jeffrey E. Markowitz and Christopher J. Rozell | Summary: Systems neuroscience has experienced an explosion of new tools for reading and writing neural activity, enabling exciting new experiments such as all-optical or closed-loop […]


Continue.. Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed

3D map-guided modeling of functional endometrial tissue using multi-compartment assembloids

Kavli Affiliate: Denis Wirtz | KEHAN REN, VICTORIA DUARTE, XIN DI ZHOU, BRYAN HO, ANDRE FORJAZ, ASHLEIGH CRAWFORD, GRETCHEN M ALICEA-REBECCA, SAURABH JOSHI, PRAFUL R NAIR, EBAN A HANNA and DENIS WIRTZ | Summary: The human endometrium is a dynamic tissue that lines the uterus and undergoes constant remodeling, making it especially susceptible to gynecological […]


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Dynamic representation of sound locations during task engagement in marmoset auditory cortex

Kavli Affiliate: Patricia Janak | Shivam Kalhan, Robin Magnard, Yifeng Cheng and Patricia H. Janak | Summary: In auditory cortex, neural responses to stimuli inside receptive fields (RFs) can be further facilitated by behavioral demands, such as attending to a spatial location. It is less clear how off-RF stimuli modulate neural responses and contribute to […]


Continue.. Dynamic representation of sound locations during task engagement in marmoset auditory cortex

Uncertainty and reward histories have distinct effects on decisions after wins and losses

Kavli Affiliate: Patricia Janak | Shivam Kalhan, Robin Magnard, Yifeng Cheng and Patricia H. Janak | Summary: Intelligent behavior necessitates an adaptive integration of feedback. It is well-known that animals asymmetrically learn from positive and negative feedback. While asymmetrical learning is a robust behavioral effect, the latent computations behind how animals represent their environments and […]


Continue.. Uncertainty and reward histories have distinct effects on decisions after wins and losses

Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)

Kavli Affiliate: Alexander Szalay | Authors: Tricia R Cottrell, Jeffrey S Roskes, Michael Fotheringham, Emily Cohen, Boyang Zhang, Logan L Engle, Daphne Wang, Elizabeth Will, Joel C Sunshine, Daniel Jimenez-Sanchez, Zhen Zheng, Justina X Caushi, Jiajia Zhang, Nina D’Amiano, Julie Stein-Deutsch, Sonali Uttam, Katie Pirie, Darah Vlaminck, Michelle Mataj, Alexa Fiorante, Nicole Espinosa, Teodora Popa, […]


Continue.. Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)

Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

Kavli Affiliate: Denis Wirtz | Authors: Devon E Mason, Megan Goeckel, Sebastian L Vega, Pei-Hsun Wu, Dymonn Johnson, Su-Jin Heo, Denis Wirtz, Jason A Burdick, Levi Wood, Brain Y Chow, Amber N Stratman and Joel D Boerckel | Summary: Vascular morphogenesis requires persistent endothelial cell motility that is responsive to diverse and dynamic mechanical stimuli. […]


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Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex

Kavli Affiliate: Alex Kolodkin and Solange Brown | Authors: Alan Y. Gutman-Wei, Sriram Sudarsanam, Alec G. Cabalinan, Naseer Shahid, Anny Shi, Luis E. Guzman Clavel, Sophia M. Spindler-Krage, Amit Agarwal, Alex L. Kolodkin and Solange P. Brown | Summary: The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased […]


Continue.. Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex