Optogenetic Central Amygdala Stimulation is Highly Reinforcing and Strongly Outcompetes Fentanyl Self-Administration in Male, but not Female, Rats

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Patricia Janak | Authors: Emma Chaloux-Pinette, Maricela Vela Mirelez-Prince, Samantha Soto, Kirtana Ananth, Xiao Tong, Vanessa Silva, Daniela Rodriguez and Patricia H Janak | Summary: The central nucleus of the amygdala plays a key role in many aspects of substance use disorders, in particular biasing behaviors toward one drug or natural reward over […]


Continue.. Optogenetic Central Amygdala Stimulation is Highly Reinforcing and Strongly Outcompetes Fentanyl Self-Administration in Male, but not Female, Rats

Electrical Coordinated Reset Stimulation Induces Network Desynchronization in an in Vivo Model of Status Epilepticus

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Sridevi Sarma | Authors: Daniel Ehrens, Fadi Aeed, Yara Otor, Vivek Charu, Babak Razavi, Sridevi V Sarma, Yitzhak Schiller and Peter A Tass | Summary: Epilepsy, a neurological disorder characterized by recurrent seizures, profoundly impacts individuals worldwide. Various electrical stimulation protocols have been investigated to mitigate epileptic seizures, among which Coordinated Reset (CR) […]


Continue.. Electrical Coordinated Reset Stimulation Induces Network Desynchronization in an in Vivo Model of Status Epilepticus

Resting-state connectivity modifies the effects of amyloid on cognitive and physical function: evidence for network-based cognitive reserve

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Michael Miller | Authors: Paul J Laurienti, Stephen B Kritchevsky, Robert G Lyday, Michael E Miller, Samuel N Lockhart, Melissa M Rundle, Christina E Hugenschmidt, Jonathan H Burdette, Heather M Shappell, Haiying Chen, Laura D Baker, Blake R Neyland and Roee Holtzer | Summary: Cognitive and physical function are interrelated in aging co-occurring […]


Continue.. Resting-state connectivity modifies the effects of amyloid on cognitive and physical function: evidence for network-based cognitive reserve

Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Keri Martinowich | Authors: Daianna Gonzalez-Padilla, Nicholas J. Eagles, Marisol Cano, Geo Pertea, Andrew E. Jaffe, Kristen R. Maynard, Dana B. Hancock, James T. Handa, Keri Martinowich and Leonardo Collado-Torres | Summary: Maternal smoking during pregnancy (MSDP) is associated with significant cognitive and behavioral effects on offspring. While neurodevelopmental outcomes have been studied […]


Continue.. Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain

xIV-LDDMM Toolkit: A Suite of Image-Varifold Based Technologies for Representing and Mapping 3D Imaging and Spatial-omics Data Simultaneously Across Scales

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Laurent Younes and Michael Miller | Authors: Kaitlin Stouffer, Xiaoyin Chen, Hongkui Zeng, Benjamin Charlier, Laurent Younes, Alain Trouve and Michael I Miller | Summary: Advancements in imaging and molecular techniques enable the collection of subcellular-scale data. Diversity in measured features, resolution, and physical scope of capture across technologies and experimental protocols pose […]


Continue.. xIV-LDDMM Toolkit: A Suite of Image-Varifold Based Technologies for Representing and Mapping 3D Imaging and Spatial-omics Data Simultaneously Across Scales

A consensus definition for deep layer 6 excitatory neurons in mouse neocortex

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Solange Brown, Loyal Goff, and Patrick Kanold | Authors: Su-Jeong Kim, Travis A. Babola, Kihwan Lee, Chanel J. Matney, Alina C. Spiegel, Michael H. Liew, Eva M. Schulteis, Austin E. Coye, Mikhail Proskurin, Hyunwook Kang, Julia A. Kim, Maxime Chevee, Kiwoong Lee, Patrick O. Kanold, Loyal A. Goff, Juhyun Kim and Solange P […]


Continue.. A consensus definition for deep layer 6 excitatory neurons in mouse neocortex

GeneCover: A Combinatorial Approach for Label-free Marker Gene Selection

Posted by dbos Hopkins

Kavli Affiliate: Laurent Younes | Authors: An Wang, Stephanie C Hicks, Donald Geman and Laurent Younes | Summary: The selection of marker gene panels is critical for capturing the cellular and spatial heterogeneity in the expanding atlases of single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics data. Most current approaches to marker gene selection operate in […]


Continue.. GeneCover: A Combinatorial Approach for Label-free Marker Gene Selection

Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Mustansir Pindwarawala, Faiyaz A. K. Abid, Jaeeun Lee, Michael L. Miller, Juliet S. Noppers, Andrew P. Rideout and Melina A. Agosto | Summary: Summary: Synaptic transmission from photoreceptors to ON-bipolar cells (BCs) requires the postsynaptic metabotropic glutamate receptor mGluR6, located at BC dendritic tips. Binding of the neurotransmitter glutamate […]


Continue.. Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants

Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

Posted by dbos Columbia, Hopkins

Kavli Affiliate: Michael Beer | Authors: Joseph F Hoff, Kirsty E Goudar, Michael Beer, Philip Hinchliffe, John M Shaw, Catherine L Tooke, Yuiko Takebayashi, Adrian J Mulholland, Christopher J Schofield and James Spencer | Summary: Carbapenemases, β-lactamases hydrolysing carbapenem antibiotics, severely challenge treatment of multi-drug resistant bacterial infections. OXA-48 is among the most widely disseminated […]


Continue.. Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

Separating the control of moving and holding still in post-stroke arm paresis

Posted by klaurent Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Alkis M. Hadjiosif, Kahori Kita, Scott T. Albert, Robert A. Scheidt, Reza Shadmehr and John W. Krakauer | Summary: Moving and holding still have been posited to be under separate control regimes for both eye and arm movements. The paretic arm after stroke is notable for abnormalities both at […]


Continue.. Separating the control of moving and holding still in post-stroke arm paresis