Temporally-segregated dual functions for Gfi1 in the development of retinal direction-selectivity

Kavli Affiliate: Alex Kolodkin | Authors: Karina Chaudhari, Luis E Guzman-Clavel and Alex L Kolodkin | Summary: There is great diversity in retinal ganglion cells subtypes in the mouse retina, but little is known about the molecular factors required to generate this subtype diversity. Here, we identify the transcription factor Gfi1 as a conserved driver […]


Continue.. Temporally-segregated dual functions for Gfi1 in the development of retinal direction-selectivity

Fentanyl reinforcement history has sex-specific effects on multi-step decision-making

Kavli Affiliate: Patricia Janak | Authors: Eric Garr, Yifeng Cheng, Andy Dong and Patricia H. Janak | Summary: It is commonly thought that drug addiction involves a transition to habitual control of action, where the choice to consume drugs becomes automatized and reflects a failure to deliberate over possible negative outcomes. Determining whether the pursuit […]


Continue.. Fentanyl reinforcement history has sex-specific effects on multi-step decision-making

Common and distinct neural correlates of social interaction perception and theory of mind

Kavli Affiliate: Martin Lindquist | Authors: Zizhuang Miao, Heejung Jung, Philip A. Kragel, Ke Bo, Patrick Sadil, Martin A. Lindquist and Tor D. Wager | Summary: Social interaction perception and theory of mind (ToM) frequently co-occur, but their commonalities and distinctions at behavioral and neural levels remain unclear. Participants (N = 231) provided moment-by-moment ratings […]


Continue.. Common and distinct neural correlates of social interaction perception and theory of mind

Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

Kavli Affiliate: Patrick Kanold | Authors: HiJee Kang, Travis Babola and Patrick O Kanold | Summary: Sensory information is represented by small neuronal ensembles in sensory cortices. Neuronal activity shows high trial-by-trial variability in that repeated presentation of the same stimulus, e. g., multiple presentations of the same sound activate differing ensembles in the auditory […]


Continue.. Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s disease

Kavli Affiliate: Michael Miller | Authors: Bowen Jin, Katherine S.-M. Brown, Denis S. Smirnov, Samuel M. Naik, Samantha L. Kirkham, Elizabeth L. Hennessey, Guanlan Dong, Shulin Mao, Samadhi P. Wijethunga, Theresa Connors Stewart, Dennis J. Selkoe, Matthew P. Frosh, Derek H. Oakley, Bradley T. Hyman, August Yue Huang and Michael Miller | Summary: Tau deposition […]


Continue.. Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s disease

The shape of attention: How cognitive goals sculpt cortical representation of speech.

Kavli Affiliate: Mounya Elhilali | Authors: Moïra-Phoebé Huet and Mounya Elhilali | Summary: Perception requires more than passive sensing—it involves prioritizing the features most relevant to ongoing cognitive goals, a process guided by selective attention. A central question is whether attention operates by enhancing all features of a selected target, or by optimizing neural encoding […]


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Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

Kavli Affiliate: Jean Fan | Authors: Srujan Singh, Shishir Kumar Patel, Ryo Matsuura, Dee Velazquez, Zhaoli Sun, Sanjeev Noel, Hamid Rabb and Jean Fan | Summary: Kidney transplantation is the gold standard treatment strategy for end-stage renal disease. Deceased donor kidneys usually undergo cold storage until kidney transplantation, leading to cold ischemia injury that may […]


Continue.. Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain

Kavli Affiliate: Michael Miller | Authors: P Monroe Butler, Anna Francis, Angela L Meunier, Amirah K Anderson, Elizabeth L Hennessey, Michael B Miller, Cynthia A Lemere, Dennis J Selkoe and Andrew M Stern | Summary: Importance Anti-amyloid immunotherapy is used to treat Alzheimer disease (AD) with moderate benefits and potentially serious side effects due to […]


Continue.. Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain

Shared and distinct cortical mechanisms for working memory and decision-making.

Kavli Affiliate: Daeyeol Lee | Authors: Hyojung Seo, Daeyeol Lee and Shanna K Murray | Summary: The dorsolateral prefrontal cortex (DLPFC) and lateral intraparietal cortex (LIP) in the primate brain are critically involved in working memory during tasks that require the retention of information over a delay. These same regions have also been implicated in […]


Continue.. Shared and distinct cortical mechanisms for working memory and decision-making.

Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Kavli Affiliate: Michael Miller | Authors: Maria Luisa Amaral, Sainath Mamde, Michael Miller, Xiaomeng Hou, Jessica Arzavala, Julia Osteen, Elizabeth Walker Smoot, Qian Yang, Emily Eisner, Qiurui Zeng, Cindy Tatiana Baez-Becerra, Jacqueline Olness, Joseph Colin Kern, Jonathan Rink, Nicholas Johnson, Ariana Barcoma, Silvia Cho, Stella Cao, Nora Emerson, Jasper Lee, Jackson Willier, Timothy Loe, Henry […]


Continue.. Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging