Kavli Affiliate: Kenneth Miller | Authors: Shen Wang, Agostina Palmigiano, Kenneth D Miller and Stephen David Van Hooser | Summary: Cross-orientation suppression is a classic form of contextual normalization in visual cortex, yet the degree to which cortical circuits participate in the normalization computation is unclear. We visualized orientation maps of individual ferrets, and provided […]
Kavli Affiliate: Stefano Fusi and Kenneth Miller | Authors: Mario Dipoppa, Ramon Nogueira, Stéphane Bugeon, Yoni Friedman, Charu B. Reddy, Kenneth D. Harris, Dario L. Ringach, Kenneth D. Miller, Matteo Carandini and Stefano Fusi | Summary: Allogeneic stem cell transplant (alloSCT) for patients with relapsed/refractory chronic lymphocytic Sensory adaptation dynamically changes neural responses as a […]
Kavli Affiliate: Nathaniel Sawtell | Authors: Qianyun Zhang, Salomon Z Muller, LF Abbott and Nathaniel B Sawtell | Summary: The dorsal cochlear nucleus (DCN) is a cerebellum-like structure in the mammalian auditory brainstem that combines auditory nerve input with diverse auditory and non-auditory signals conveyed by granule cells. Granule cells form excitatory synapses onto inhibitory […]
Kavli Affiliate: Rui Costa | Authors:Michele Garibbo, Carolina Filipe, Laurence Aitchison and Rui Ponte Costa | Summary: Learning depends on both reward- and error-based feedback, yet how the brain integrates these distinct signals to guide behaviour remains fundamentally unclear. Here, using a normative computational framework, we derive credit assignment rules for both reward-based learning (RBL) […]
Kavli Affiliate: Franck Polleux | Authors: Sergio Bernal-Garcia, Regina Jiang and Franck Polleux | Summary: In cortical circuits, synaptic plasticity involves either changes in the weight of pre-existing synapses, referred to as functional synaptic plasticity, or synapse formation and elimination, referred to as structural synaptic plasticity. Experience-dependent structural synaptic plasticity is prominent in juvenile cortical […]
Kavli Affiliate: Rafael Yuste | Authors: Dean Geckt, Netanel Ofer, Michael W Reimann, Rafael Yuste and Idan Segev | Summary: Dendritic spines are the principal postsynaptic targets of excitatory synapses, yet the network logic governing their organization and contribution to cortical computation remains unclear. Here, we combine the MICrONS ultrastructural reconstruction of mouse visual cortex […]
Kavli Affiliate: Scott Small | Authors: Angel G Rivera-Colón, Scott T Small, Erin Jezuit, John P Wares and Andrew D Kern | Summary: Population size is a key factor underlying the mode and tempo of evolution, particularly as it relates to the strength of selection and drift. While the mechanisms underlying the interactions between population […]
Kavli Affiliate: Rui Costa | Authors: Will Greedy, Heng Wei Zhu, Alexia Duriez, Joseph Pemberton, Patrick T. McCarthy, Kevin Kermani Nejad and Rui Ponte Costa | Summary: Learning is thought to arise from synaptic modifications embedded in brain-wide circuits 1–3, yet how such circuits coordinate plasticity to support complex behaviour is not known 4,5. Inspired […]
Kavli Affiliate: Vincent Ferrera | Authors: Vincent P. Ferrera, Samuel Lippl, Kenneth Kay, Fabian Munoz, Yuhao Jin, Greg Jensen and Herbert S. Terrace | Summary: Transitive inference (TI) is the ability to reason about transitive relationships in an ordered set of items (e.g., if A>B and B>C, then A>C). TI is widely held to depend […]
Kavli Affiliate: Stefano Fusi | Authors: Nicholas Menghi, Simone Vigano’, William Jeffrey Johnston, Salma Elnagar, Stefano Fusi and Christian F Doeller | Summary: Learning depends not only on the content of what we learn, but also on how we learn and on how experiences are structured over time. To investigate how task similarity and […]