Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Julie Borovicka, Hale Tobin, Shruti Bhatia, Jacob Icardi, Ghazaal Tahmasebi, Priyanka Agochiya, Shriya Singh, Bruce Trapp and Hod Dana | Summary: Damage to the myelin sheath that protects axons in the central nervous system is a hallmark pathology of demyelinating diseases like multiple sclerosis. Cuprizone-induced demyelination in […]
Kavli Affiliate: Michael Shadlen | Authors: Ariel Zylberberg and Michael N Shadlen | Summary: Confidence in a decision is the belief, prior to feedback, that one’s choice is correct. In the brain, many decisions are implemented as a race between competing evidence-accumulation processes. We ask whether the neurons that represent evidence accumulation also carry information […]
Kavli Affiliate: Kenneth Miller | Authors: Mauro M. Monsalve-Mercado and Kenneth D Miller | Summary: How do populations of neurons collectively encode and process information during cognitive tasks? We analyze high-yield population recordings from the macaque lateral intraparietal area (LIP) during a reaction-time random-dot-motion direction-discrimination task. We find that the trajectories of neural population activity […]
Kavli Affiliate: Stefano Fusi and Kenneth Miller | Authors: Mario Dipoppa, Ramon Nogueira, Stéphane Bugeon, Yoni Friedman, Charu B. Reddy, Kenneth D. Harris, Dario L. Ringach, Kenneth D. Miller, Matteo Carandini and Stefano Fusi | Summary: Allogeneic stem cell transplant (alloSCT) for patients with relapsed/refractory chronic lymphocytic Sensory adaptation dynamically changes neural responses as a […]
Kavli Affiliate: Stefano Fusi | Authors: Nicholas Menghi, William Jeffrey Johnston, Simone Vigano’, Max Andreas Bosse Hinrichs, Burkhard Maess, Stefano Fusi and Christian F Doeller | Summary: The complexity of our environment poses significant challenges for adaptive behavior. Recognizing shared structures across tasks can theoretically improve learning through generalization. However, how such shared representations emerge […]
Kavli Affiliate: Richard Axel | Authors: Andrew Jacob Pixley Fink, Samuel Muscinelli, Shuqi Wang, Marcus I Hogan, Daniel Fine English, Richard Axel, Ashok Litwin-Kumar and Carl E. Schoonover | Summary: Organisms continually tune their perceptual systems to the features they encounter in their environment1–3. We have studied how ongoing experience reorganizes the synaptic connectivity of […]
Kavli Affiliate: Rui Costa | Authors: Sara Moberg, Michele Garibbo, Camille Mazo, Ariel Gilad, Dietmar Schmitz, Rui Ponte Costa, Matthew E Larkum and Naoya Takahashi | Summary: Adaptive behavior is critically dependent on associative learning, where environmental cues are linked with subsequent positive or negative outcomes. In mammals, primary neocortical sensory areas serve as pivotal […]
Kavli Affiliate: Liam Paninski | Authors: International Brain Lab, Brandon Benson, Julius Benson, Daniel Birman, Niccolo Bonacchi, Matteo Carandini, Joana A Catarino, Gaelle A Chapuis, Anne K Churchland, Yang Dan, Peter Dayan, Eric EJ DeWitt, Tatiana A Engel, Michele Fabbri, Mayo Faulkner, Ila Rani Fiete, Charles Findling, Laura Freitas-Silva, Berk Gercek, Kenneth D Harris, Michael […]
Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Nathaniel D. Daw and Daphna Shohamy | Summary: We are often faced with decisions we have never encountered before, requiring us to infer possible outcomes before making a choice. Computational theories suggest that one way to make these types of decisions is by accessing and linking related […]
Kavli Affiliate: Liam Paninski | Authors: Stefano Fusi and Liam Paninski | Summary: The brain is highly structured both at anatomical and functional levels. However, within individual brain areas, neurons often exhibit very diverse and seemingly disorganized responses. A more careful analysis shows that these neurons can sometimes be grouped together into specialized subpopulations (categorical […]