Kavli Affiliate: Mark Churchland | Authors: Sean M. Perkins, Elom A. Amematsro, John P. Cunningham, Qi Wang and Mark M. Churchland | Summary: Decoders for brain-computer interfaces (BCIs) assume constraints on neural activity, chosen to reflect scientific beliefs while yielding tractable computations. Recent scientific advances suggest that the true constraints on neural activity, especially its […]

Kavli Affiliate: Elizabeth Hillman | Authors: Hongkun Zhu, Andrew J Michalak, Edward M Merricks, Alexander H. C. W. Agopyan-Miu, Joshua Jacobs, Marla J Hamberger, Sameer Sheth, Guy M McKhann, Neil Feldstein, Catherine Schevon and Elizabeth M. C. Hillman | Summary: Despite abundant evidence of functional networks in the human brain, their neuronal underpinnings, and relationships […]

Kavli Affiliate: Wei Min | Authors: Xiao Guo, Mina Farag, Naixin Qian, Xia Yu, Anton Ni, Yuefeng Ma, Wen Yu, Matthew King, Vicky Liu, Joonho Lee, Wei Min, Richard N Zare, Rohit V Pappu and Yifan Dai | Summary: TWe report the discovery that chemical reactions such as ATP hydrolysis can be catalyzed by condensates […]

Kavli Affiliate: Franck Polleux | Authors: Carlos Diaz-Salazar, Marine A KRZISCH, Juyoun Yoo, Patricia Nano, Aparna Bhaduri, Rudolph Jaenisch and Franck Polleux | Summary: Microglia play key roles in shaping synaptic connectivity during neural circuits development. Whether microglia display human-specific features of structural and functional maturation is currently unknown. We show that the ancestral gene […]

Kavli Affiliate: Liam Paninski | Authors: The International Brain Laboratory, Kush Banga, Julius Benson, Niccolò Bonacchi, Sebastian A Bruijns, Rob Campbell, Gaëlle A Chapuis, Anne K Churchland, M Felicia Davatolhagh, Hyun Dong Lee, Mayo Faulkner, Fei Hu, Julia Hunterberg, Anup Khanal, Christopher Krasniak, Guido T Meijer, Nathaniel J Miska, Zeinab Mohammadi, Jean-Paul Noel, Liam Paninski, […]

Kavli Affiliate: Attila Losonczy and Franck Polleux | Authors: Justin K. O’Hare, Jamie Wang, Margjele D. Shala, Franck Polleux and Attila Losonczy | Summary: Hippocampal pyramidal neurons support episodic memory by integrating complementary information streams into new ‘place fields’. Distal tuft dendrites are widely thought to initiate place field formation by locally generating prolonged, globally-spreading […]

Kavli Affiliate: Wei Min | Authors: Shan Jiang, Lu Chen, Wei-Min Qu, Zhi-Li Huang and Chang-Rui Chen | Summary: General anesthesia is a fundamental process required to undertake safely and humanely a high fraction of surgeries and invasive diagnostic procedures. However, the undesired stress response associated with general anesthesia (GA) causes delayed recovery and even […]

Kavli Affiliate: Steven Siegelbaum; | Authors: Lara M. Boyle, Wanhui Sheng, Felix Leroy, Rhea Sahai, Sarah Irfan, Heon-Jin Lee, Andres Villegas, W. Scott Young and Steven A Siegelbaum | Summary: Although it is well-known that the hippocampus mediates declarative memory (the repository of information of people, places, things and events) and influences behavior, the differential […]

Kavli Affiliate: Franck Polleux; | Authors: Sergio B. Garcia, Alexa P. Schlotter, Daniela Pereira, Franck Polleux and Luke Hammond | Summary: Accurate and unbiased reconstructions of neuronal morphology, including quantification of dendritic spine morphology and distribution, are widely used in neuroscience but remain a major roadblock for large-scale analysis. Traditionally, spine analysis has required labor-intensive […]