Kavli Affiliate: Liam Paninski | Authors: Samaher Fageiry, Claire L Warriner, Jackson Loper, Liam Paninski, Thomas Reardon, Thomas M. Jessell, Rui M. Costa and Andrew Miri | Summary: The corticospinal tract exerts its influence on movement through spinal neurons, which can be divided into types that exhibit distinct functions. However, it remains unknown whether these […]
Kavli Affiliate: Attila Losonczy | Authors: Stephanie A Herrlinger, Bovey Rao, Margaret E Conde Paredes, Anna L Tuttman, Haroon Arain, Erdem Varol, Joseph A Gogos and Attila Losonczy | Summary: Individuals with the 22q11.2 deletion syndrome, one of the strongest genetic risk factors for schizophrenia, demonstrate cognitive impairments such as episodic memory dysfunction. Place cell […]
Kavli Affiliate: Stefano Fusi, Daniel Salzman | Authors: Pia-Kelsey O’Neill, Lorenzo Posani, Jozsef Meszaros, Phebe Warren, Carl E. Schoonover, Andrew J.P. Fink, Stefano Fusi and C. Daniel Salzman | Summary: Sensory stimuli associated with aversive outcomes can cause multiple behavioral responses related to an animal’s evolving emotional state. We employed chemogenetic inactivation and two-photon imaging […]
Kavli Affiliate: Seth Blackshaw | Authors: Dong Won Kim, Soohyun Kim, Jeong Han, Karan Belday, Emily Li, Nicholas Mahoney, Seth Blackshaw and Fatemeh Rajaii | Summary: Despite recent advances in the treatment of thyroid eye disease (TED), significant gaps remain in our understanding of the underlying molecular mechanisms, particularly concerning the insulin-like growth factor-1 receptor […]
Kavli Affiliate: Xiaoqin Wang | Authors: Liam Paninski and Nathaniel Sawtell | Summary: To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single neuron and single spike resolution. Extracellular electrophysiology delivers this, but it has biases in the neurons it detects and it imperfectly resolves their […]
Kavli Affiliate: Attila Losonczy | Authors: Kyu Sang Han, Inbal B Sander, Jacqueline Kumer, Eric Preston Resnick, Clare Booth, Bartholomew Starich, Jeremy Walston, Ashley L Kiemen, Sashank Reddy, Corrine Joshu, Joel Sunshine, Denis Wirtz and Pei-Hsun Wu | Summary: Investigators conducting behavioral experiments often need precise control over the timing of the delivery of stimuli […]
Kavli Affiliate: Vincent Ferrera | Authors: Samuel Lippl, Kenneth Kay, Greg Jensen, Vincent P. Ferrera and L.F. Abbott | Summary: Humans and animals routinely infer relations between different items or events and generalize these relations to novel combinations of items (“compositional generalization”). This allows them to respond appropriately to radically novel circumstances and is fundamental […]
Kavli Affiliate: Elizabeth Hillman | Authors: Sam E. Benezra, Kripa B. Patel, Citlali Pérez Campos, Elizabeth M. C. Hillman and Randy M Bruno | Summary: Learning alters cortical representations and improves perception. Apical tuft dendrites in Layer 1, which are unique in their connectivity and biophysical properties, may be a key site of learning-induced plasticity. […]
Kavli Affiliate: Attila Losonczy | Authors: Jingcheng Shi, Boaz Nutkovich, Dahlia Kushinsky, Bovey Y Rao, Stephanie A Herrlinger, Tiberiu S Mihaila, Katayun Cohen-Kashi Malina, Cliodhna K OToole, Margaret E Conde Paredes, Hyun C Yong, Erdem Varol, Attila Losonczy and Ivo Spiegel | Summary: Neural circuits are characterized by genetically and functionally diverse cell types. A […]
Kavli Affiliate: Scott Small | Authors: Gabrielle C. Coffing, Silas Tittes, Scott T. Small, Jeremea O. Songco-Casey, Denise M. Piscopo, Judit R. Pungor, Adam C Miller, Cristopher Niell and Andrew D. Kern | Summary: Sex chromosomes are critical elements of sexual reproduction in many animal and plant taxa, however they show incredible diversity and rapid […]