In vivo cell-type and brain region classification via multimodal contrastive learning

Kavli Affiliate: Liam Paninski | Authors: Han Yu, Hanrui Lyu, Ethan YiXun Xu, Charlie Windolf, Eric Kenji Lee, Fan Yang, Andrew M Shelton, Shawn Olsen, Sahar Minavi, Olivier Winter, The International Brain Laboratory, Eva L Dyer, Chandramouli Chandrasekaran, Nicholas A Steinmetz, Liam Paninski and Cole Hurwitz | Summary: Current electrophysiological approaches can track the activity […]


Continue.. In vivo cell-type and brain region classification via multimodal contrastive learning

Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

Kavli Affiliate: Attila Losonczy | Authors: Stephanie A Herrlinger, Jiayao Wang, Bovey Y Rao, Jonathan Chang, Joseph Gogos, Attila Losonczy and Dennis Vitkup | Summary: Neuropsychiatric disorders such as autism spectrum disorder (ASD) and schizophrenia (SCZ) share genetic risk factors, including rare high penetrance single nucleotide variants and copy number variants (CNVs), and exhibit both […]


Continue.. Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

Kavli Affiliate: Ann McDermott | Authors: Chengming He, Nikhil R Varghese, Eric G Keeler, Chi L L Pham, Brayden Williams, Stephan Tetter, Crystal Semaan, Karyn L Wilde, Simon H J Brown, James C Bouwer, Yann Gambin, Emma Sierecki, Megan Steain, Margaret Sunde and Ann E McDermott | Summary: The formation of RIP-homotypic interaction motif (RHIM)-based […]


Continue.. Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

Deficiency of mitophagy mediator Parkin in aortic smooth muscle cells exacerbates abdominal aortic aneurysm

Kavli Affiliate: Robert Hawkins | Authors: Hui Wang, Matthew Kazaleh, Rachel A. Gioscia-Ryan, Jessica Millar, Gerard Temprano-Sagrera, Sherri Wood, Fran Van Den Burgh, Muriel G Blin, Kathleen M Wragg, Adrain Luna, Robert Bruce Hawkins, Scott A Soleimanpour, Maria Sabater-Lleal, Chang Shu, Daniel A Beard, Gorav Ailawadi, Jane C Deng, Daniel R Goldstein and Morgan Salmon […]


Continue.. Deficiency of mitophagy mediator Parkin in aortic smooth muscle cells exacerbates abdominal aortic aneurysm

Distinct representations of an anxiogenic environment in different cell types of the ventral hippocampus

Kavli Affiliate: Stefano Fusi and René Hen | Authors: Jack E Berry, Jessica C Jimenez, Wei-Li Chang, Kenechukwu Michael Ogbu, Nicholas Manfred, Karly Tegang, Stefano Fusi, René Hen and Clay Lacefield | Summary: In addition to its role in episodic memory and spatial navigation, the hippocampus has also been found to influence mood-related disorders such […]


Continue.. Distinct representations of an anxiogenic environment in different cell types of the ventral hippocampus

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primates

Kavli Affiliate: Vincent Ferrera | Authors: Alec J. Batts, Robin Ji, Sua Bae, Fotios N. Tsitsos, Sergio Jiménez-Gambín, Nancy Kwon, Samantha L. Gorman, Deny Tsakri, Rebecca L. Noel, Jonas Bendig, Daniella A. Jimenez, Melody DiBenedetto, Sofia A. Del Castillo, Filimon B. Keleta, James Caicedo, Alexander Romanov, Colleen T. Curley, Yulia Dzhashiashvili, Greglynn D. Walton-Gibbs, Bradley […]


Continue.. Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primates

An evolutionarily conserved role for separase in the regulation of nuclear lamins

Kavli Affiliate: Michael Goldberg | Authors: Francesca Cipressa, Gaelle Pennarun, Giuseppe Bosso, Serena Rosignoli, Liliana Tullo, Nadia Schiralli, Chiara Borghi, Alessandro Paiardini, Michael L Goldberg, Pascale Bertrand and Giovanni Cenci | Summary: Separase is a well conserved endopeptidase that facilitates sister chromatid separation at the metaphase-anaphase transition by cleaving cohesins. Beyond its role in chromosome […]


Continue.. An evolutionarily conserved role for separase in the regulation of nuclear lamins

RESPAN: A Deep Learning Pipeline for Accurate and Automated Restoration, Segmentation, and Quantification of Dendritic Spines

Kavli Affiliate: Franck Polleux | Authors: Sergio B. Garcia, Alexa P. Schlotter, Daniela Pereira, Aleksandra J Recupero, Franck Polleux and Luke A Hammond | Summary: Quantification of dendritic spines is essential for studying synaptic connectivity, yet most current approaches require manual adjustments or the combination of multiple software tools for optimal results. Here, we present […]


Continue.. RESPAN: A Deep Learning Pipeline for Accurate and Automated Restoration, Segmentation, and Quantification of Dendritic Spines

Circuit-Based Understanding of Fine Spatial Scale Clustering of Orientation Tuning in Mouse Visual Cortex

Kavli Affiliate: Kenneth Miller | Authors: Peijia Yu, Yuhan Yang, Olivia Gozel, Ian Oldenburg, Mario Dipoppa, Federico Rossi, Kenneth Miller, Hillel Adesnik, Na Ji and Brent Doiron | Summary: In sensory cortex of brain it is often the case that neurons are spatially organized by their functional properties. A hallmark of primary visual cortex (V1) […]


Continue.. Circuit-Based Understanding of Fine Spatial Scale Clustering of Orientation Tuning in Mouse Visual Cortex

Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

Kavli Affiliate: Stefano Fusi | Authors: Lorenzo Posani, Shuqi Wang, Samuel Muscinelli, Liam Paninski and Stefano Fusi | Summary: A long-standing debate in neuroscience concerns whether individual neurons are organized into functionally distinct populations that encode information differently (“categorical” representations [1–3]) and the implications for neural computation. Here, we systematically analyzed how cortical neurons encode […]


Continue.. Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy