Combinatorial transcription factor binding encodes cis-regulatory wiring of forebrain GABAergic neurogenesis

Posted by klaurent UCSF

Kavli Affiliate: John Rubenstein | Authors: Rinaldo Catta-Preta, Susan Lindtner, Athena Ypsilanti, James Price, Armen Abnousi, Linda Su-Feher, Yurong Wang, Ivan Juric, Ian Jones, Jennifer Akiyama, Ming Hu, Yin Shen, Axel Visel, Len Pennacchio, Diane Dickel, John Rubenstein and Alex Nord | Summary: Transcription factors (TFs) bind combinatorially to genomic cis-regulatory elements (cREs), orchestrating transcription […]


Continue.. Combinatorial transcription factor binding encodes cis-regulatory wiring of forebrain GABAergic neurogenesis

Divergence Based Quadrangle and Applications

Posted by klaurent UCAS

Kavli Affiliate: Cheng Peng | First 5 Authors: Anton Malandii, Siddhartha Gupte, Cheng Peng, Stan Uryasev, | Summary: This paper introduces a novel framework for assessing risk and decision-making in the presence of uncertainty, the emph{$varphi$-Divergence Quadrangle}. This approach expands upon the traditional Risk Quadrangle, a model that quantifies uncertainty through four key components: emph{risk, […]


Continue.. Divergence Based Quadrangle and Applications

Divergence Based Quadrangle and Applications

Posted by klaurent UCAS

Kavli Affiliate: Cheng Peng | First 5 Authors: Anton Malandii, Siddhartha Gupte, Cheng Peng, Stan Uryasev, | Summary: This paper introduces a novel framework for assessing risk and decision-making in the presence of uncertainty, the emph{$varphi$-Divergence Quadrangle}. This approach expands upon the traditional Risk Quadrangle, a model that quantifies uncertainty through four key components: emph{risk, […]


Continue.. Divergence Based Quadrangle and Applications

Synthetic Gaia DR3 surveys from the FIRE cosmological simulations of Milky-Way-mass galaxies

Posted by klaurent MIT

Kavli Affiliate: Lina Necib | First 5 Authors: Tri Nguyen, Xiaowei Ou, Nondh Panithanpaisal, Nora Shipp, Lina Necib | Summary: The third data release (DR3) of Gaia has provided a five-fold increase in the number of radial velocity measurements of stars, as well as a stark improvement in parallax and proper motion measurements. To help […]


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Searching for the nano-Hertz stochastic gravitational wave background with the Chinese Pulsar Timing Array Data Release I

Posted by klaurent Peking

Kavli Affiliate: Kejia Lee | First 5 Authors: Heng Xu, Siyuan Chen, Yanjun Guo, Jinchen Jiang, Bojun Wang | Summary: Observing and timing a group of millisecond pulsars (MSPs) with high rotational stability enables the direct detection of gravitational waves (GWs). The GW signals can be identified from the spatial correlations encoded in the times-of-arrival […]


Continue.. Searching for the nano-Hertz stochastic gravitational wave background with the Chinese Pulsar Timing Array Data Release I

Diffuse neutrino background from past core-collapse supernovae

Posted by klaurent Tokyo

Kavli Affiliate: Shunsaku Horiuchi | First 5 Authors: Shin’ichiro Ando, Nick Ekanger, Shunsaku Horiuchi, Yusuke Koshio, | Summary: Core-collapse supernovae are among the most powerful explosions in the universe, emitting thermal neutrinos that carry away the majority of the gravitational binding energy released. These neutrinos create a diffuse supernova neutrino background (DSNB), one of the […]


Continue.. Diffuse neutrino background from past core-collapse supernovae

Diffuse neutrino background from past core-collapse supernovae

Posted by klaurent Tokyo

Kavli Affiliate: Shunsaku Horiuchi | First 5 Authors: Shin’ichiro Ando, Nick Ekanger, Shunsaku Horiuchi, Yusuke Koshio, | Summary: Core-collapse supernovae are among the most powerful explosions in the universe, emitting thermal neutrinos that carry away the majority of the gravitational binding energy released. These neutrinos create a diffuse supernova neutrino background (DSNB), one of the […]


Continue.. Diffuse neutrino background from past core-collapse supernovae

Diffuse neutrino background from past core-collapse supernovae

Posted by klaurent Tokyo

Kavli Affiliate: Shunsaku Horiuchi | First 5 Authors: Shin’ichiro Ando, Nick Ekanger, Shunsaku Horiuchi, Yusuke Koshio, | Summary: Core-collapse supernovae are among the most powerful explosions in the universe, emitting thermal neutrinos that carry away the majority of the gravitational binding energy released. These neutrinos create a diffuse supernova neutrino background (DSNB), one of the […]


Continue.. Diffuse neutrino background from past core-collapse supernovae

The evolution and mutational robustness of chromatin accessibility in Drosophila

Posted by klaurent Rockefeller

Kavli Affiliate: Li Zhao | Authors: Samuel Khodursky, Eric B Zheng, Nicolas Svetec, Sylvia M Durkin, Sigi Benjamin, Alice Gadau, Xia Wu and Li Zhao | Summary: The evolution of regulatory regions in the genome plays a critical role in shaping the diversity of life. While this process is primarily sequence-dependent, the enormous complexity of […]


Continue.. The evolution and mutational robustness of chromatin accessibility in Drosophila

Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling

Posted by klaurent NTNU

Kavli Affiliate: Menno Witter | Authors: Katrine Sjaastad Hanssen, Nicolai Winter-Hjelm, Salome Nora Niethammer, Asgeir Kobro-Flatmoen, Menno P. Witter, Axel Sandvig and Ioanna Sandvig | Summary: Engineered biological neural networks are indispensable tools for investigating neural function in both healthy and diseased states from the subcellular to the network level. Neurons in vitro self-organize over […]


Continue.. Reverse Engineering of Feedforward Cortical-Hippocampal Neural Networks Relevant for Preclinical Disease Modelling