LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Variants in leucine rich repeat kinase 2 (LRRK2) that increase kinase activity confer risk for sporadic and familial forms of Parkinson’s disease. However, LRRK2-dependent cellular processes responsible for disease risk remain uncertain. Here we show that LRRK2 negatively regulates lysosome degradative […]


Continue.. LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Posted by klaurent Yale

Kavli Affiliate: Nenad Sestan | Authors: Suel-Kee Kim, Seungmae Seo, Genevieve Stein-O’Brien, Amritha Jaishankar, Kazuya Ogawa, Nicola Micali, Victor Luria, Amir Karger, Yanhong Wang, Thomas M. Hyde, Joel E. Kleinman, Ty Voss, Elana J. Fertig, Joo-Heon Shin, Roland Bürli, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad […]


Continue.. Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Posted by klaurent UCSF

Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]


Continue.. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Multi-center integrated analysis of non-coding CRISPR screens

Posted by klaurent Hopkins

Kavli Affiliate: Michael Beer | Authors: David Yao, Josh Tycko, Woo Oh, Lexi R. Bounds, Sager J. Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R. Doughty, Idan Gabdank, Henri Schmidt, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunahi Luo, Keith Siklenka, Galip Gurkan Yardimci, The ENCODE4 Consortium, Ryan Tewhey, Anshul Kundaje, William J. Greenleaf, Pardis […]


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Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Posted by klaurent Cornell

Kavli Affiliate: Jeevak M. Parpia | First 5 Authors: Rakin N. Baten, Yefan Tian, Eric N. Smith, Erich Mueller, Jeevak M. Parpia | Summary: By monitoring the quality factor of a quartz tuning fork oscillator we have observed a fluctuation-driven reduction in the viscosity of bulk $^3$He in the normal state near the superfluid transition […]


Continue.. Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Posted by klaurent Cornell

Kavli Affiliate: Jeevak M. Parpia | First 5 Authors: Rakin N. Baten, Yefan Tian, Eric N. Smith, Erich Mueller, Jeevak M. Parpia | Summary: By monitoring the quality factor of a quartz tuning fork oscillator we have observed a fluctuation-driven reduction in the viscosity of bulk $^3$He in the normal state near the superfluid transition […]


Continue.. Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Single-cell RNA sequencing analyses of primary cutaneous B-cell disorders reveal distinct molecular patterns consistent with clinical behavior

Posted by klaurent NTNU

Kavli Affiliate: Vy Thuy Nguyen | Authors: Johannes Griss, Mathias C Drach, Vy Nguyen, Jasmine P Levine, Felix Thaler, Marco A Medjimorec, Lisa E Shaw, Ulrike Mann, Wolfgang Weninger, Christine Wagner, Stephan Wagner, Ingrid Simonitsch-Klupp, Matthias Farlik, Constanze Jonak and Patrick M Brunner | Summary: Cutaneous B-cell lymphomas (CBL) comprise a diverse group of diseases […]


Continue.. Single-cell RNA sequencing analyses of primary cutaneous B-cell disorders reveal distinct molecular patterns consistent with clinical behavior

The inflation hierarchy and the polarization hierarchy are complete for the quantum bilocal scenario

Posted by klaurent UCSB

Kavli Affiliate: David Gross | First 5 Authors: Laurens T. Ligthart, David Gross, , , | Summary: It is a fundamental but difficult problem to characterize the set of correlations that can be obtained by performing measurements on quantum mechanical systems. The problem is particularly challenging when the preparation procedure for the quantum states is […]


Continue.. The inflation hierarchy and the polarization hierarchy are complete for the quantum bilocal scenario

The inflation hierarchy and the polarization hierarchy are complete for the quantum bilocal scenario

Posted by klaurent UCSB

Kavli Affiliate: David Gross | First 5 Authors: Laurens T. Ligthart, David Gross, , , | Summary: It is a fundamental but difficult problem to characterize the set of correlations that can be obtained by performing measurements on quantum mechanical systems. The problem is particularly challenging when the preparation procedure for the quantum states is […]


Continue.. The inflation hierarchy and the polarization hierarchy are complete for the quantum bilocal scenario

Continuous Trajectory Optimization via B-splines for Multi-jointed Robotic Systems

Posted by klaurent Berkeley

Kavli Affiliate: Ting Xu | First 5 Authors: Changhao Wang, Ting Xu, Masayoshi Tomizuka, , | Summary: Continuous formulations of trajectory planning problems have two main benefits. First, constraints are guaranteed to be satisfied at all times. Secondly, dynamic obstacles can be naturally considered with time. This paper introduces a novel B-spline based trajectory optimization […]


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