HP6/Umbrea, a rapidly evolving Drosophila HP1-family paralog, is a candidate HP1a-recruited plasticizer of heterochromatin

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: UnJin Lee and Li Zhao | Summary: HP6/Umbrea, a rapidly evolving Drosophila (Heterochromatin Protein 1) HP1-family paralog, has well-documented sequence and regulatory evolution but an under-studied molecular function. In this manuscript, we hypothesize that HP6/Umbrea acts as an HP1-recruited plasticizer, providing support for this model using coarse-grained molecular-dynamics simulations of HP1a […]


Continue.. HP6/Umbrea, a rapidly evolving Drosophila HP1-family paralog, is a candidate HP1a-recruited plasticizer of heterochromatin

Evolution of MOSN, a novel sex-specifically spliced neuronal gene in the Aedes aegypti mosquito

Posted by dbos Rockefeller

Kavli Affiliate: Leslie B. Vosshall | Authors: Yael N Tsitohay, Nipun S Basrur, Umberto Palatini, Alexandra E DeFoe, Thomas A Jones, Junhui Peng, Margaret Herre, Li Zhao, Sean R Eddy, Nadav Shai and Leslie B Vossha | Summary: Sex-specific RNA splicing is a conserved mechanism for generating sexual dimorphism in insects, with the beststudied examples […]


Continue.. Evolution of MOSN, a novel sex-specifically spliced neuronal gene in the Aedes aegypti mosquito

Quantum-enhanced ghost imaging recognition via joint optimization of speckle patterns and quantum network parameters

Posted by klaurent Caltech

Kavli Affiliate: Anqi Zhang| Summary:Ghost imaging enables nonlocal image reconstruction and exhibits strong robustness against interference, but achieving high-fidelity recognition at ultra-low sampling rates remains challenging. Quantum machine learning offers a novel approach for efficient feature extraction on noisy medium-scale quantum devices; however, existing methods generally suffer from low recognition accuracy and weak noise resistance. […]


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Bumpy inflation from explosive particle production

Posted by klaurent Tokyo

Kavli Affiliate: Misao Sasaki | Summary:We present a first-principles derivation of an effective inflaton potential with a bumpy feature. We consider the coupling of a spectator field χto the inflaton φsuch that χis massive enough for almost all values of φ, but becomes massless when the inflaton crossed the value φ_star. This gives rise to […]


Continue.. Bumpy inflation from explosive particle production

Bumpy inflation from explosive particle production

Posted by klaurent Tokyo

Kavli Affiliate: Misao Sasaki | Summary:We present a first-principles derivation of an effective inflaton potential with a bumpy feature. We consider the coupling of a spectator field χto the inflaton φsuch that χis massive enough for almost all values of φ, but becomes massless when the inflaton crossed the value φ_star. This gives rise to […]


Continue.. Bumpy inflation from explosive particle production

ELUCID-DESI II. Revealing dark matter mass, tidal, and velocity (MTV) fields using galaxy group phase information

Posted by klaurent Peking

Kavli Affiliate: Yingjie Peng | Summary:We introduce a novel method for reconstructing the cosmic mass, tidal, and velocity (MTV) fields over the redshift range $0 < z < 0.6$ using the phase information of galaxy groups. This approach replaces the explicit theoretical bias correction typically needed to relate galaxy groups to the underlying dark matter […]


Continue.. ELUCID-DESI II. Revealing dark matter mass, tidal, and velocity (MTV) fields using galaxy group phase information

A mechanism for attenuating responses to anticipated sounds in the dorsal cochlear nucleus

Posted by dbos Columbia

Kavli Affiliate: Nathaniel Sawtell | Authors: Qianyun Zhang, Salomon Z Muller, LF Abbott and Nathaniel B Sawtell | Summary: The dorsal cochlear nucleus (DCN) is a cerebellum-like structure in the mammalian auditory brainstem that combines auditory nerve input with diverse auditory and non-auditory signals conveyed by granule cells. Granule cells form excitatory synapses onto inhibitory […]


Continue.. A mechanism for attenuating responses to anticipated sounds in the dorsal cochlear nucleus

Multiscale spatial transcriptomics resolves the cellular and molecular architecture of the human amygdala

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Michael S. Totty, Svitlana V. Bach, Madeline R. Valentine, Madhavi Tippani, Sarah E. Maguire, Ishbel Del Rosario Alvia, Ryan A. Miller, Joel E. Kleinman, Kristen R. Maynard, Stephanie Cerceo Page, Thomas M. Hyde, Stephanie C. Hicks and Keri Martinowich | Summary: The amygdala is a central hub for emotional […]


Continue.. Multiscale spatial transcriptomics resolves the cellular and molecular architecture of the human amygdala

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

Posted by dbos UCSF

Kavli Affiliate: Graeme Davis | Authors: Jacob Ellegood, Antoine Beauchamp, Yohan Yee, Gabe Devenyi, Justine Ziolkowski, Lily Qiu, Rand Askalan, Muhammad Ayub, Philipp Suetterlin, Alex Donovan, M. Albert Basson, Katherine M Quesnel, Nathalie G Berube, Taeseon Woo, David Beversdorf, Hans Bjornsson, Randy Blakely, Froylan Calderon de Anda, Jacqueline Crawley, Jennifer Crosbie, Brian O Orr, Graeme […]


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Loss-tolerant hybrid metasurface mirror for reducing coating Brownian noise in precision optical cavities

Posted by klaurent MIT

Kavli Affiliate: Peter Fritschel | Summary:We propose a hybrid mirror design that places an embedded metasurface beneath a Bragg reflector, combining the low coating Brownian noise of metasurface mirrors with the low optical loss of conventional multilayer coatings. Unlike previous hybrid designs, which place the metasurface at the input surface, our design positions it below […]


Continue.. Loss-tolerant hybrid metasurface mirror for reducing coating Brownian noise in precision optical cavities