Bile acid signaling as a therapeutically tractable pathway linking early caregiving adversity to social behavior

Posted by dbos Hopkins

Kavli Affiliate: Maya Opendak | Authors: Cesar Medina, Pragney Deme, Vishal Win, Isabellah Nikitah, Isaac S McKie, Mingyuan Song, Maria Raudales, Elaina Regier, Emily Amsden, Pranali Bendale, Norman Haughey and Maya Opendak | Summary: Adverse early caregiving produces lasting changes in social behavior and increases vulnerability to psychiatric illness, yet the biological pathways through which […]


Continue.. Bile acid signaling as a therapeutically tractable pathway linking early caregiving adversity to social behavior

Dendritic spines implement specific connectivity and support neuronal ensembles in cortical circuits

Posted by dbos Columbia

Kavli Affiliate: Rafael Yuste | Authors: Dean Geckt, Netanel Ofer, Michael W Reimann, Rafael Yuste and Idan Segev | Summary: Dendritic spines are the principal postsynaptic targets of excitatory synapses, yet the network logic governing their organization and contribution to cortical computation remains unclear. Here, we combine the MICrONS ultrastructural reconstruction of mouse visual cortex […]


Continue.. Dendritic spines implement specific connectivity and support neuronal ensembles in cortical circuits

Activity-induced weakening of hippocampal input to prefrontal VIP interneurons reshapes inhibitory microcircuit function: implications for spatial working memory task acquisition.

Posted by dbos UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Shana E Silverstein, Thomas T Clarity, Meena S Deshpande, Erik Vaughan, Shoshana Novik, Hector E Yarur, Shiliang Zhang, Valerie S Tsai, Rong Ye, Rachel M Mikofsky, Madeline Hsiang, Avery Bauman, Gabriel Loewinger, Francisco Pereira, Marisela Morales, Vikaas S Sohal, Hugo Tejeda, Joshua A Gordon and David A Kupferschmidt | […]


Continue.. Activity-induced weakening of hippocampal input to prefrontal VIP interneurons reshapes inhibitory microcircuit function: implications for spatial working memory task acquisition.

Discovery Stack Pilot Demonstrates the Feasibility and Outcomes of a Scientist-Designed Peer-Review Model That Separates Quality and Impact

Posted by dbos Rockefeller

Kavli Affiliate: Yifan Cheng | Authors: Maureen A McGargill, Beiyun C Liu, Michael S Kuhns, Daniel Mucida, Isabella Rauch, Lauren B Rodda, Meghan A Koch, Hugo Gonzalez Velozo, Ken Cadwell, Tanya S Freedman, Tiffany C Scharschmidt, Richard Sever, Jose Ordovas-Montanes, Sara Suliman, Andrew Oberst, Brooke Runnette and Matthew F Krummel | Summary: Peer review serves […]


Continue.. Discovery Stack Pilot Demonstrates the Feasibility and Outcomes of a Scientist-Designed Peer-Review Model That Separates Quality and Impact

ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Hao Wu, Upneet Kaur, Chengmin Li, Elise N. Munoz, Geeta J. Narlikar and Yifan Cheng | Summary: ATP-dependent chromatin remodeling enzymes play central roles in genome regulation by mobilizing nucleosomes. All remodelers except for one, position their core ATPase at an internal nucleosome location, superhelical location (SHL) 2, and […]


Continue.. ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

Biphasic acclimation for simultaneous wide-field fluorescent Ca2+ imaging and fMRI of awake mice

Posted by dbos Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Francesca Mandino, Taekyung Kang, Xilin Shen, Corey Horien, Xenophon Papademetris, Stephen M. Strittmatter and Evelyn MR Lake | Summary: Functional magnetic resonance imaging (fMRI) can be applied in mice and humans making it a key technology in translational neuroimaging research. Yet, most fMRI studies in rodents use anesthesia to […]


Continue.. Biphasic acclimation for simultaneous wide-field fluorescent Ca2+ imaging and fMRI of awake mice

Low Ly$α$ Visibility in Galaxy Overdensities: Reionization Topology and Neutral-Fraction Ceilings from DIVER over $4.8

Posted by klaurent Cambridge

Kavli Affiliate: Roberto Maiolino | Summary:Ly-alpha emission is widely used to trace cosmic reionization, but its interpretation depends on how Ly-alpha visibility varies with galaxy environment. We use deep JWST/NIRSpec observations from Deep Insights into UV Spectroscopy at the Epoch of Reionization (DIVER) in GOODS-N to measure Ly-alpha visibility for 250 galaxies at 4.8<z<11. The […]


Continue.. Low Ly$α$ Visibility in Galaxy Overdensities: Reionization Topology and Neutral-Fraction Ceilings from DIVER over $4.8

The THESAN-ZOOM project: clumpiness of high-redshift galaxies and its connection to bursty star formation

Posted by klaurent MIT

Kavli Affiliate: Mark Vogelsberger | Summary:Recent JWST observations have revealed diverse high-redshift galaxy morphologies, including a population with irregular and clumpy structures. The physical origin of these structures, and the extent to which observational biases shape their appearance, remain uncertain. We present a power-spectrum-based method for quantifying galaxy clumpiness across spatial scales, using the radiation-hydrodynamic […]


Continue.. The THESAN-ZOOM project: clumpiness of high-redshift galaxies and its connection to bursty star formation

The Challenge of Observing Patchy Reionization with CMB Optical-Depth Fluctuations

Posted by klaurent Chicago

Kavli Affiliate: Nickolay Gnedin | Summary:Spatial fluctuations in the Thomson optical depth encode information about the inhomogeneous nature of cosmic reionization. We compute the optical-depth angular power spectrum, $C_ell^ττ$, using past lightcones constructed from five Cosmic Reionization on Computers (CROC) radiation-hydrodynamical simulations. By decomposing the electron-density field into patchy and density components, we quantify the […]


Continue.. The Challenge of Observing Patchy Reionization with CMB Optical-Depth Fluctuations

Identifying Cost-Favorable Locations for Cosmic Explorer

Posted by klaurent MIT

Kavli Affiliate: David Shoemaker | Summary:Cosmic Explorer (CE) is a proposed next-generation gravitational-wave observatory that aims to extend our gravitational-wave vision to the edge of the observable universe. With a foundation of technology proven by the National Science Foundation’s Laser Interferometer Gravitational-Wave Observatory (LIGO), CE will observe black holes and neutron stars across cosmic time, […]


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