Single-cell long-read sequencing of the experience-induced transcriptome

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Richard Huganir | Authors: Sheridan Cavalier, Paul W Hook, Richard L. Huganir and Winston Timp | Summary: Neural activity drives transcriptional events that are critical for learning. Activity-induced transcript isoform expression and alternative splicing are cell-type specific events typically obscured by sequencing approaches that restrict read length. We combined single-cell transcriptomics with Nanopore […]


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Scalable Training for Vector-Quantized Networks with 100% Codebook Utilization

Posted by klaurent This Week: Theoretical Physics, UCAS

Kavli Affiliate: Zheng Zhu | First 5 Authors: Yifan Chang, Yifan Chang, , , | Summary: Vector quantization (VQ) is a key component in discrete tokenizers for image generation, but its training is often unstable due to straight-through estimation bias, one-step-behind updates, and sparse codebook gradients, which lead to suboptimal reconstruction performance and low codebook […]


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QuantAgent: Price-Driven Multi-Agent LLMs for High-Frequency Trading

Posted by klaurent Berkeley, This Week: Nanoscience

Kavli Affiliate: Xiang Zhang | First 5 Authors: Fei Xiong, Fei Xiong, , , | Summary: Recent advances in Large Language Models (LLMs) have demonstrated impressive capabilities in financial reasoning and market understanding. Multi-agent LLM frameworks such as TradingAgent and FINMEM augment these models to long-horizon investment tasks, leveraging fundamental and sentiment-based inputs for strategic […]


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SLD-Spec: Enhancement LLM-assisted Specification Generation for Complex Loop Functions via Program Slicing and Logical Deletion

Posted by klaurent This Week: Theoretical Physics, UCAS

Kavli Affiliate: Long Zhang | First 5 Authors: Zehan Chen, Zehan Chen, , , | Summary: Automatically generating formal specifications from program code can greatly enhance the efficiency of program verification and enable end-to-end automation from requirements to reliable software. However, existing LLM-based approaches often struggle with programs that include complex loop structures, leading to […]


Continue.. SLD-Spec: Enhancement LLM-assisted Specification Generation for Complex Loop Functions via Program Slicing and Logical Deletion