Kavli Affiliate: Shawn Ferguson | Authors: Amanda Bentley-DeSousa and Shawn Ferguson | Summary: Mutations that increase LRRK2 kinase activity have been linked to Parkinson’s disease and Crohn’s disease. LRRK2 is also activated by lysosome damage evoked by chemical and pathogenic stimuli. However, the endogenous cellular mechanisms that control LRRK2 kinase activity are not well understood. […]
Continue.. A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes