LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Variants in leucine rich repeat kinase 2 (LRRK2) that increase kinase activity confer risk for sporadic and familial forms of Parkinson’s disease. However, LRRK2-dependent cellular processes responsible for disease risk remain uncertain. Here we show that LRRK2 negatively regulates lysosome degradative […]


Continue.. LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Posted by klaurent Yale

Kavli Affiliate: Nenad Sestan | Authors: Suel-Kee Kim, Seungmae Seo, Genevieve Stein-O’Brien, Amritha Jaishankar, Kazuya Ogawa, Nicola Micali, Victor Luria, Amir Karger, Yanhong Wang, Thomas M. Hyde, Joel E. Kleinman, Ty Voss, Elana J. Fertig, Joo-Heon Shin, Roland Bürli, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad […]


Continue.. Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Posted by klaurent UCSF

Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]


Continue.. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury