BDNF and TRiC-inspired Reagents Rescue Cortical Synaptic Deficits in a Mouse Model of Huntington’s Disease

Posted by klaurent UCSD / Salk

Kavli Affiliate: William Mobley | Authors: Yingli Gu, Alexander Pope, Charlene Smith-Geater, Christopher Carmona, Aaron Johnstone, Linda Shi, Xuqiao Chen, Sarai Santos, Claire C Bacon-Brenes, Thomas Shoff, Korbin M Kleczko, Judith Frydman, Leslie M Thompson, William C Mobley and Chengbiao Wu | Summary: Abstract Huntington’s disease (HD) results from a CAG repeat expansion in the […]


Continue.. BDNF and TRiC-inspired Reagents Rescue Cortical Synaptic Deficits in a Mouse Model of Huntington’s Disease

The SPHERE view of three interacting twin disc systems in polarised light

Posted by dbos MIT

Kavli Affiliate: David Principe | First 5 Authors: Philipp Weber, Sebastián Pérez, Greta Guidi, Nicolás T. Kurtovic, Alice Zurlo | Summary: Dense stellar environments as hosts of ongoing star formation increase the probability of gravitational encounters among stellar systems during the early stages of evolution. Stellar interaction may occur through non-recurring, hyperbolic or parabolic passages […]


Continue.. The SPHERE view of three interacting twin disc systems in polarised light

The SPHERE view of three interacting twin disc systems in polarised light

Posted by dbos MIT

Kavli Affiliate: David Principe | First 5 Authors: Philipp Weber, Sebastián Pérez, Greta Guidi, Nicolás T. Kurtovic, Alice Zurlo | Summary: Dense stellar environments as hosts of ongoing star formation increase the probability of gravitational encounters among stellar systems during the early stages of evolution. Stellar interaction may occur through non-recurring, hyperbolic or parabolic passages […]


Continue.. The SPHERE view of three interacting twin disc systems in polarised light

Ganymede MHD Model: Magnetospheric Context for Juno’s PJ34 Flyby

Posted by klaurent MIT

Kavli Affiliate: George Clark | First 5 Authors: Stefan Duling, Joachim Saur, George Clark, Frederic Allegrini, Thomas Greathouse | Summary: On June 7th, 2021 the Juno spacecraft visited Ganymede and provided the first in situ observations since Galileo’s last flyby in 2000. The measurements obtained along a one-dimensional trajectory can be brought into global context […]


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Logarithmic Duality of the Curvature Perturbation

Posted by klaurent Tokyo

Kavli Affiliate: Misao Sasaki | First 5 Authors: Shi Pi, Misao Sasaki, , , | Summary: We study the comoving curvature perturbation $mathcal{R}$ in the single-field inflation models whose potential can be approximated by a piecewise quadratic potential $V(varphi)$ by using the $delta N$ formalism. We find a general formula for $mathcal{R}(deltavarphi, deltapi)$, consisting of […]


Continue.. Logarithmic Duality of the Curvature Perturbation

Logarithmic Duality of the Curvature Perturbation

Posted by klaurent Tokyo

Kavli Affiliate: Misao Sasaki | First 5 Authors: Shi Pi, Misao Sasaki, , , | Summary: We study the comoving curvature perturbation $mathcal{R}$ in the single-field inflation models whose potential can be approximated by a piecewise quadratic potential $V(varphi)$ by using the $delta N$ formalism. We find a general formula for $mathcal{R}(deltavarphi, deltapi)$, consisting of […]


Continue.. Logarithmic Duality of the Curvature Perturbation

Multiplexed and scalable cellular phenotyping toward the standardized three-dimensional human neuroanatomy

Posted by klaurent Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Tatsuya C. Murakami and Nathaniel Heintz | Summary: Abstract The advent of three-dimensional histological methods has advanced studies of cellular-resolution anatomy of the brain. The use of whole-mount staining and tissue clearing has advanced systems-level identification of cells underlying brain functions in mouse models. However, application of these methods […]


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Copiotrophs dominate rhizosphere microbiomes and growth rate potential is a major factor explaining the rhizosphere effect

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: José Luis López, Nikolaos Pappas, Sanne WM Poppeliers, Juan J. Sanchez-Gil, Arista Fourie-Fouche, Ronnie de Jonge and Bas E. Dutilh | Summary: Abstract The structure and function of the root microbial community is shaped by plant root activity, enriching specific microbial taxa and functions from the surrounding soil […]


Continue.. Copiotrophs dominate rhizosphere microbiomes and growth rate potential is a major factor explaining the rhizosphere effect

Multiplexed selectivity screening of anti-GPCR antibodies

Posted by klaurent Rockefeller

Kavli Affiliate: Thomas P. Sakmar | Authors: Leo Dahl, Ilana Kotliar, Annika Bendes, Tea Dodig-Crnkovic, Samuel Fromm, Arne Elofsson, Mathias Uhlen, Thomas P Sakmar and Jochen Schwenk | Summary: Abstract G protein-coupled receptors (GPCRs) control critical cellular signaling pathways. Therapeutic agents, such as antibodies (Abs), are being developed to modulate GPCR signaling pathways. However, validating […]


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