Endosomal hyper-acidification via proton-activated chloride channel deletion in neurons impairs AMPA receptor endocytosis and LTD

Posted by dbos Hopkins

Kavli Affiliate: Richard Huganir | Authors: Kevin Chen, Junhua Yang, Bian Liu, Chaohua Jiang, Nicholas Koylass, Zhe Zhang, Shuying Sun, Richard L. Huganir and Zhaozhu Qiu | Summary: Endosomal homeostasis is critical for neuronal function, including the post-synaptic trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). Dynamic AMPAR trafficking is a major component of synaptic plasticity, such […]


Continue.. Endosomal hyper-acidification via proton-activated chloride channel deletion in neurons impairs AMPA receptor endocytosis and LTD

Latent-TGF-β has a domain swapped architecture

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Mingliang Jin, Robert Seed, Tiffany Shing, Yifan Cheng and Stephen Nishimura | Summary: The multifunctional cytokine TGF-β is produced in a latent form (L-TGF-β) where a RGD containing homodimeric prodomain forms a “ring” encircling mature TGF-β shielding it from its receptors. Thus L-TGF-β must be activated to function, a […]


Continue.. Latent-TGF-β has a domain swapped architecture

Intel(R) SHMEM: GPU-initiated OpenSHMEM using SYCL

Posted by klaurent Stanford

Kavli Affiliate: Philip Marshall | Summary:Modern high-end systems are increasingly becoming heterogeneous, providing users options to use general purpose Graphics Processing Units (GPU) and other accelerators for additional performance. High Performance Computing (HPC) and Artificial Intelligence (AI) applications are often carefully arranged to overlap communications and computation for increased efficiency on such platforms. This has […]


Continue.. Intel(R) SHMEM: GPU-initiated OpenSHMEM using SYCL

Mechanism Design for Congested Facility Location

Posted by klaurent UCAS

Kavli Affiliate: Cheng Peng | First 5 Authors: Cheng Peng, Cheng Peng, , , | Summary: This paper investigates mechanism design for congested facility location problems, where agents are partitioned into groups with conflicting interests (e.g., competition for booking a basketball court in a gymnasium), and each agent’s cost increases when the facility is located […]


Continue.. Mechanism Design for Congested Facility Location

Testing the Coherent State Description of Radiation Fields

Posted by klaurent MIT

Kavli Affiliate: Frank Wilczek | Summary:We propose simple quantitative criteria, based on counting statistics in resonant harmonic detectors, that probe the quantum mechanical character of radiation fields. They provide, in particular, practical means to test the null hypothesis that a given field is “maximally classical”, i.e., accurately described by a coherent state. We suggest circumstances […]


Continue.. Testing the Coherent State Description of Radiation Fields

Local HI Absorption towards the Magellanic Cloud foreground using ASKAP

Posted by dbos Stanford

Kavli Affiliate: Susan E. Clark | First 5 Authors: Hiep Nguyen, N. M. McClure-Griffiths, James Dempsey, John M. Dickey, Min-Young Lee | Summary: We present the largest Galactic neutral hydrogen HI absorption survey to date, utilizing the Australian SKA Pathfinder Telescope at an unprecedented spatial resolution of 30”. This survey, GASKAP-HI, unbiasedly targets 2,714 continuum […]


Continue.. Local HI Absorption towards the Magellanic Cloud foreground using ASKAP

The search for light dark matter with DAMIC-M

Posted by klaurent Chicago

Kavli Affiliate: Radomir Smida | Summary:The DAMIC-M (DArk Matter In CCDs at Modane) experiment will use skipper CCDs to search for low mass (sub-GeV) dark matter underground at the Laboratoire Souterrain de Modane (LSM) in France. With about 1 kg of silicon target mass and sub-electron energy resolution, the detector will surpass the exposure and […]


Continue.. The search for light dark matter with DAMIC-M

Explanation of high redshift luminous galaxies from JWST by early dark energy model

Posted by dbos Peking

Kavli Affiliate: Hu Zhan | First 5 Authors: Jun-Qian Jiang, Weiyang Liu, Hu Zhan, Bin Hu, | Summary: Recent observations from the James Webb Space Telescope (JWST) have uncovered massive galaxies at high redshifts, with their abundance significantly surpassing expectations. This finding poses a substantial challenge to both galaxy formation models and our understanding of […]


Continue.. Explanation of high redshift luminous galaxies from JWST by early dark energy model

Explanation of high redshift luminous galaxies from JWST by early dark energy model

Posted by dbos Peking

Kavli Affiliate: Hu Zhan | First 5 Authors: Jun-Qian Jiang, Weiyang Liu, Hu Zhan, Bin Hu, | Summary: Recent observations from the James Webb Space Telescope (JWST) have uncovered massive galaxies at high redshifts, with their abundance significantly surpassing expectations. This finding poses a substantial challenge to both galaxy formation models and our understanding of […]


Continue.. Explanation of high redshift luminous galaxies from JWST by early dark energy model