Kavli Affiliate: Michael Keiser | Authors: William J. Connell, Kristle Garcia, Hani Goodarzi and Michael J. Keiser | Summary: Chemical probes interrogate disease mechanisms at the molecular level by linking genetic changes to observable traits. However, comprehensive chemical screens in diverse biological models are impractical. To address this challenge, we developed ChemProbe, a model that […]
Kavli Affiliate: Timothy Brown | Authors: Richard J McDowell, Altug Didikoglu, Tom Woelders, Mazie J Gatt, Roelof A. Hut, Timothy M Brown and Robert J Lucas | Summary: Background Light is a key environmental regulator of physiology and behaviour. Mistimed or insufficient light disrupts circadian rhythms and is associated with impaired health and well-being across […]
Kavli Affiliate: Cynthia F. Moss | Authors: Michael A Pardo, Kurt Fristrup, David S Lolchuragi, Joyce Poole, Petter Granli, Cynthia Moss, Iain Douglas-Hamilton and George Wittemyer | Summary: Personal names are a universal feature of human language, yet few analogs exist in other species. While dolphins and parrots address conspecifics by imitating the calls of […]
Kavli Affiliate: Seth Shipman | Authors: Manuel Peter, Seth Shipman and Jeffrey D Macklis | Summary: Differentiation of human pluripotent stem cells (hPSC) into distinct neuronal populations holds substantial potential for disease modeling in vitro, toward both elucidation of pathobiological mechanisms and screening of potential therapeutic agents. For successful differentiation of hPSCs into subtype-specific neurons […]
Kavli Affiliate: Roger Nicoll | Authors: XIUMIN CHEN, Qixu Cai, jing zhou, Samuel J Pleasure, Howard Schulman, Mingjie Zhang and Roger A Nicoll | Summary: CaMKII plays a critical role in long-term potentiation (LTP), a well-established model for learning and memory through the enhancement of synaptic transmission. Biochemical studies indicate that CaMKII catalyzes a phosphotransferase […]
Kavli Affiliate: Mark Ellisman | Authors: Cristiane dos Santos, Shristi Shrestha, Matthew A Cottam, Guy Perkins, Varda Lev-Ram, Birbickram Roy, Christopher Acree, Keun-Young Kim, Thomas Deerinck, Melanie Cutler, Danielle Dean, Jean Philippe Cartailler, Patrick E MacDonald, Martin W Hetzer, Mark H Ellisman and Rafael Arrojo e Drigo | Summary: Caloric restriction (CR) extends organismal lifespan […]
Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Jonathan S Marvin, Alexandros C Kokotos, Mukesh Kumar, Camila Pulido, Ariana N Tkachuk, Jocelyn Shuxin Yao, Timothy A Brown and Timothy A Ryan | Summary: We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in subcellular […]
Kavli Affiliate: Luis C. Ho | First 5 Authors: Ailing Wang, Tao An, Yingkang Zhang, Xiaopeng Cheng, Luis C. Ho | Summary: This study uses multi-frequency Very Long Baseline Interferometry (VLBI) to study the radio emission from 10 radio-quiet quasars (RQQs) and four radio-loud quasars (RLQs). The diverse morphologies, radio spectra, and brightness temperatures observed […]
Kavli Affiliate: Cheng Peng | First 5 Authors: Yan Cheng, Peng Yang, Ning Zhang, Jiawei Hou, | Summary: To enhance on-road environmental perception for autonomous driving, accurate and real-time analytics on high-resolution video frames generated from on-board cameras be-comes crucial. In this paper, we design a lightweight object location method based on class activation mapping […]
Kavli Affiliate: Gregory J. Herczeg | First 5 Authors: Yifan Zhou, Brendan P. Bowler, Haifeng Yang, Aniket Sanghi, Gregory J. Herczeg | Summary: The proposed protoplanet AB Aur b is a spatially concentrated emission source imaged in the mm-wavelength disk gap of the Herbig Ae/Be star AB Aur. Its near-infrared spectrum and absence of strong […]