Kavli Affiliate: Robert Rosner | Summary:Cancer and healthy cells have distinct distributions of molecular properties and thus respond differently to drugs. Cancer drugs ideally kill cancer cells while limiting harm to healthy cells. However, the inherent variance among cells in both cancer and healthy cell populations increases the difficulty of selective drug action. Here we […]
Kavli Affiliate: Jacqueline Barton| First 5 Authors: Nithyanandan Thyagarajan, Nithyanandan Thyagarajan, , , | Summary:In this paper we explore for the first time the relative magnitudes of three fundamental sources of uncertainty, namely, foreground contamination, thermal noise and sample variance in detecting the HI power spectrum from the Epoch of Reionization (EoR). We derive limits […]
Kavli Affiliate: Claude Canizares | Summary:We present observations of the SS 433 jets using the Chandra High Energy Transmission Grating Spectrometer with contemporaneous optical and VLBA observations. The X-ray and optical emission line regions are found to be related but not coincident as the optical line emission persists for days while the X-ray emission lines […]
Kavli Affiliate: Mark Vagins | Summary:The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay — these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, […]
Kavli Affiliate: Daniel Ralph| First 5 Authors: Paul Ralph, Paul Ralph, , , | Summary:Many academics have called for increasing attention to theory in software engineering. Consequently, this paper empirically evaluates two dissimilar software development process theories – one expressing a more traditional, methodical view (FBS) and one expressing an alternative, more improvisational view (SCI). […]
Kavli Affiliate: Mikhail Shapiro | Summary:Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely new approaches may be required, motivating an analysis of the fundamental physical constraints on the problem. We outline the physical principles governing brain activity […]
Kavli Affiliate: Mark Vagins | Summary:We model the distance, extinction, and magnitude probability distributions of a successful Galactic core-collapse supernova (ccSN), its shock breakout radiation, and its massive star progenitor. We find, at very high probability (~100%), that the next Galactic SN will easily be detectable in the near-IR and that near-IR photometry of the […]
Kavli Affiliate: Sarah N. T. Heine | Summary:We present the analysis of 21 bright X-ray knots in the Cassiopeia A supernova remnant from observations spanning 10 yr. We performed a comprehensive set of measurements to reveal the kinematic and thermal state of the plasma in each knot, using a combined analysis of two high energy […]
Kavli Affiliate: Kentaro Hori | Summary:We compute the elliptic genera of two-dimensional N=(2,2) and N=(0,2) gauged linear sigma models via supersymmetric localization, for rank-one gauge groups. The elliptic genus is expressed as a sum over residues of a meromorphic function whose argument is the holonomy of the gauge field along both the spatial and the […]
Kavli Affiliate: Christopher Ober| First 5 Authors: Ulrike Ober, Ulrike Ober, , , | Summary:The expected level of linkage disequilibrium (LD) in a finite ideal population at equilibrium is of relevance for many applications in population and quantitative genetics. Several recursion formulae have been proposed during the last decades, whose derivations mostly contain heuristic parts […]