Circuit dissection and functional validation of a cross-species emotional biomarker

Kavli Affiliate: Edward Chang, Vikaas Sohal | Authors: Adam Jackson, Josh Cohen, Aarron Phensy, Edward F Chang, Heather Dawes and Vikaas Sohal | Summary: ABSTRACT Emotional responses arise from limbic circuits including the hippocampus and amygdala. In the human brain, beta-frequency communication between these structures correlates with self-reported mood and anxiety. However, both the mechanism […]


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Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens

Kavli Affiliate: Joshua Berke | Authors: Ali Mohebi, Val L Collins and Joshua D Berke | Summary: Abstract Motivation to work for potential rewards is critically dependent on dopamine (DA) in the nucleus accumbens (NAc). DA release from NAc axons can be controlled by at least two distinct mechanisms: 1) action potentials propagating from DA […]


Continue.. Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens

Astrocyte-like CEPsh glia responds to stressful environments

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, Noelle L’Etoile and RASHMI CHANDRA | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]


Continue.. Astrocyte-like CEPsh glia responds to stressful environments

Astrocyte-like CEPsh glia responds to the stressful environments

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, RASHMI CHANDRA and Noelle L’Etoile | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]


Continue.. Astrocyte-like CEPsh glia responds to the stressful environments

Astrocyte-like CEPsh glia respond to stress

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, Noelle L’Etoile and RASHMI CHANDRA | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]


Continue.. Astrocyte-like CEPsh glia respond to stress

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

Kavli Affiliate: Shankar Sundaram | Authors: Thomas A. Desautels, Kathryn T. Arrildt, Adam T. Zemla, Edmond Y. Lau, Fangqiang Zhu, Dante Ricci, Stephanie Cronin, Seth J. Zost, Elad Binshtein, Suzanne M. Scheaffer, Taylor B. Engdahl, Elaine Chen, John W. Goforth, Denis Vashchenko, Sam Nguyen, Dina R. Weilhammer, Jacky Kai-Yin Lo, Bonnee Rubinfeld, Edwin A. Saada, […]


Continue.. Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

Kavli Affiliate: Robert Edwards | Authors: Frederic Bibollet-Ruche, Ronnie M Russell, Wenge Ding, Weimin Liu, Yingying Li, Kshitij Wagh, Daniel Wrapp, Rumi Habib, Ashwin N Skelly, Ryan S Roark, Scott Sherrill-Mix, Shuyi Wang, Juliette Rando, Emily Lindemuth, Kendra Cruickshank, Younghoon Park, Rachel Baum, Andrew Connell, Hui Li, Elena E Giorgi, Ge S Song, Shilei Ding, […]


Continue.. A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes

Kavli Affiliate: John Rubenstein | Authors: Siavash Fazel Darbandi, Joon-Yong An, Kenneth Lim, Nicholas F. Page, Lindsay Liang, Athena R. Ypsilanti, Eirene Markenscoff-Papadimitriou, Matthew W. State, Alex S. Nord, Stephan J. Sanders and John L. R. Rubenstein | Summary: Abstract The authors have withdrawn their manuscript because of uncertainty about an antibody reagent that was […]


Continue.. Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes

Biogeography of human-health associated butyrate-producing bacteria

Kavli Affiliate: Robert Edwards | Authors: Joel E Brame, Craig Liddicoat, Catherine A Abbott, Robert A Edwards, Jake M Robinson, Nicolas E Gauthier and Martin F Breed | Summary: Abstract Butyrate-producing bacteria are found in many ecosystems and organisms, including humans. They ferment organic matter, producing the by-product butyrate, a short-chain fatty acid with important […]


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EMC holdase:CaV1.2/CaVβ3 complex and CaV1.2 channel structures reveal CaV assembly and drug binding mechanisms

Kavli Affiliate: Daniel Minor | Authors: Zhou Chen, Abhisek Mondal, Fayal Abderemane-Ali, Jose Montano, Balyn Zaro and Daniel L Minor, Jr. | Summary: Abstract Voltage-gated ion channels (VGICs) comprise multiple structural units whose assembly is required for function1,2. There is scant structural understanding of how VGIC subunits assemble and whether chaperone proteins are required. High-voltage […]


Continue.. EMC holdase:CaV1.2/CaVβ3 complex and CaV1.2 channel structures reveal CaV assembly and drug binding mechanisms