Kavli Affiliate:Allan Basbaum | Authors: Isha Singh, Anubha Seth, Christian B. Billesbolle, Joao Braz, Ramona M. Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Parnian Lak, Henry R O’Donnell, Walter R Sandtner, Bryan L. Roth, Allan Basbaum, William C Wetsel, Aashish Manglik, Brian K. Shoichet and Gary Rudnick | Summary: The serotonin […]
Kavli Affiliate: Peter Walter | Authors: Advait Subramanian, Lan Wang, Tom Moss, Mark Voorhies, Smriti Sangwan, Erica Stevenson, Ernst H Pulido, Samentha Kwok, Nevan J Krogan, Danielle L Swaney, Stephen N Floor, Anita Sil, Peter Walter and Shaeri Mukherjee | Summary: Pathogens often secrete proteins or nucleic acids that mimic the structure and/or function of […]
Kavli Affiliate: Daniel Minor | Authors: Zhou Chen, Sandra Zakrzewska, Holly S. Hajare, Aurora Alvarez-Buylla, Fayal Abderemane-Ali, Maximiliana Bogan, Dave Ramirez, Lauren A. O’Connell, J. Du Bois and Daniel L. Minor, Jr. | Summary: American bullfrog (Rana castesbeiana) saxiphilin (RcSxph) is a high-affinity ‘toxin sponge’ protein thought to prevent intoxication by saxitoxin (STX), a lethal […]
Kavli Affiliate: Michael Stryker | Authors: Maria C. Dadarlat, Yujiao Jennifer Sun and Michael P Stryker | Summary: Electrical stimulation has emerged as a powerful and precise treatment in which to modulate aberrant neural activity patterns common in neural dysfunction and disease; however, the physiological process involved in microstimulation is poorly understood, particularly regarding the […]
Kavli Affiliate: Seth Shipman | Authors: Santi Bhattarai-Kline, Sierra K. Lear, Chloe B. Fishman, Santiago C. Lopez, Elana R. Lockshin, Max G. Schubert, Jeff Nivala, George Church and Seth L. Shipman | Summary: Biological processes depend on the differential expression of genes over time, but methods to make physical recordings of these processes are limited. […]
Kavli Affiliate: Susanna Rosi, Peter Walter, Michael Stryker | Authors: Elma S. Frias, Mahmood S. Hoseini, Karen Krukowski, Maria Serena Paladini, Katherine Grue, Gonzalo Ureta, Kira D.A. Rienecker, Peter Walter, Michael P. Stryker and Susanna Rosi | Summary: Traumatic brain injury (TBI) is a leading cause of long-term neurological disability in the world and the […]
Kavli Affiliate: Kevin Bender | Authors: Andrew D. Nelson, Amanda M. Catalfio, Julie M. Gupta, Lia Min, René N. Caballero-Florán, Kendall P. Dean, Carina C. Elvira, Kimberly D. Derderian, Henry Kyoung, Atehsa Sahagun, Stephan J Sanders, Kevin Bender and Paul M Jenkins | Summary: Dysfunction in sodium channels and their ankyrin scaffolding partners have both […]
Kavli Affiliate: Arnold Kriegstein, Alex Pollen | Authors: Sean Whalen, Fumitaka Inoue, Hane Ryu, Tyler Fair, Eirene Markenscoff-Papadimitriou, Kathleen Keough, Martin Kircher, Beth Martin, Beatriz Alvarado, Orry Elor, Dianne Laboy Cintron, Alex Williams, Md. Abul Hassan Samee, Sean Thomas, Robert Krencik, Erik Ullian, Arnold Kriegstein, Jay Shendure, Alex Pollen, Nadav Ahituv and Katherine Pollard | […]
Kavli Affiliate: Michael Keiser | Authors: Alexandre V Fassio, Laura Shub, Luca Ponzoni, Jessica McKinley, Matthew J O’Meara, Rafaela S Ferreira, Michael J Keiser and Raquel C de Melo Minardi | Summary: Machine learning-based drug discovery success depends on molecular representation. Yet traditional molecular fingerprints omit both the protein and pointers back to structural information […]
Kavli Affiliate: John Rubenstein | Authors: Shiona Biswas, C. Savio Chan, John L.R. Rubenstein and Lin Gan | Summary: The external globus pallidus (Gpe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action. Changes in the firing of GPe neurons are associated with both […]