CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder

Kavli Affiliate: Kevin Bender, Jeanne Tamar Paz | Authors: Serena Tamura, Andrew D Nelson, Perry WE Spratt, Henry Kyoung, Xujia Zhou, Zizheng Li, Jingjing Zhao, Stephanie S Holden, Atehsa Sahagun, Caroline M Keeshen, Congyi Lu, Elizabeth C Hamada, Roy Ben-Shalom, Jen Q Pan, Jeanne T Paz, Stephan J Sanders, Navneet Matharu, Nadav Ahituv and Kevin […]


Continue.. CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder

The Neurodata Without Borders ecosystem for neurophysiological data science

Kavli Affiliate: Kristofer Bouchard, Loren Frank | Authors: Oliver Rübel, Andrew Tritt, Ryan Ly, Benjamin K. Dichter, Satrajit Ghosh, Lawrence Niu, Ivan Soltesz, Karel Svoboda, Loren Frank and Kristofer E. Bouchard | Summary: The neurophysiology of cells and tissues are monitored electrophysiologically and optically in diverse experiments and species, ranging from flies to humans. Understanding […]


Continue.. The Neurodata Without Borders ecosystem for neurophysiological data science

Persistent postnatal migration of interneurons into the human entorhinal cortex

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Marcos Assis Nascimento, Sean Biagiotti, Vicente Herranz-Perez, Raymund Bueno, Chun Jimmie Ye, Taylor Abel, Juan S Rubio Moll, Jose Manuel Garcia-Verdugo, Eric J. Huang, Arturo Alvarez-Buylla and Shawn F Sorrells | Summary: The entorhinal cortex (EC) is a highly-interconnected hub for multisensory integration and memory processing1-3, containing diverse neuronal […]


Continue.. Persistent postnatal migration of interneurons into the human entorhinal cortex

Dissecting neural computations of the human auditory pathway using deep neural networks for speech

Kavli Affiliate: Edward Chang | Authors: Yuanning Li, Gopala K Anumanchipalli, Abdelrahman Mohamed, Junfeng Lu, Jinsong Wu and Edward F Chang | Summary: The human auditory system extracts rich linguistic abstractions from the speech signal. Traditional approaches to understand this complex process have used classical linear feature encoding models, with limited success. Artificial neural networks […]


Continue.. Dissecting neural computations of the human auditory pathway using deep neural networks for speech

Cohesin erases genomic-proximity biases to drive stochastic Protocadherin expression for proper neural wiring

Kavli Affiliate: Daniele Canzio | Authors: Lea Kiefer, Gabrielle Isabelle F. Servito, Sandy M Rajkumar, Jennifer Langen, Anna Chiosso, Alexander Buckley, Elizabeth S. Cha, Adan Horta, Michael H Mui and Daniele Canzio | Summary: Clustered Protocadherin (Pcdh) proteins act as cell-surface recognition barcodes for neural circuit formation. Neurites expressing the same barcode repel each other, […]


Continue.. Cohesin erases genomic-proximity biases to drive stochastic Protocadherin expression for proper neural wiring

Not optimal, just noisy: the geometry of correlated variability leads to highly suboptimal sensory coding

Kavli Affiliate: Kristofer Bouchard | Authors: Jesse A Livezey, Pratik Singh Sachdeva, Maximilian E Dougherty, Mathew T Summers and Kristofer E Bouchard | Summary: The brain represents the world through the activity of neural populations. Correlated variability across simultaneously recorded neurons (noise correlations) has been observed across cortical areas and experimental paradigms. Many studies have […]


Continue.. Not optimal, just noisy: the geometry of correlated variability leads to highly suboptimal sensory coding

Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Predictions and Validation of a Patient-Specific Non-Linear Model

Kavli Affiliate: Philip Starr | Authors: James J. Sermon, Maria Olaru, Juan Anso, Simon Little, Rafal Bogacz, Philip A. Starr, Timothy Denison and Benoit Duchet | Summary: Background Entrainment of brain oscillations has been hypothesised as a potential mechanism of neuromodulation. While neuromodulation has been shown to be an effective therapy for a variety of […]


Continue.. Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Predictions and Validation of a Patient-Specific Non-Linear Model

Dynamic Synchronization between Hippocampal Spatial Representations and the Stepping Rhythm

Kavli Affiliate: Loren Frank | Authors: Abhilasha Joshi, Eric L. Denovellis, Abhijith Mankili, Yagiz Meneksedag, Thomas Davidson, Anna K Gillespie, Jennifer Ann Guidera, Demetris Roumis and Loren M. Frank | Summary: The hippocampus is a vertebrate brain structure that expresses spatial representations1 and is critical for navigation2,3. Navigation in turn intricately depends on locomotion; however, […]


Continue.. Dynamic Synchronization between Hippocampal Spatial Representations and the Stepping Rhythm

A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis

Kavli Affiliate: Anna Molofsky, Bjoern Schwer | Authors: Leah C. Dorman, Phi T. Nguyen, Caroline C. Escoubas, Ilia D. Vainchtein, Yinghong Xiao, Peter V. Lidsky, Haruna Nakajo, Nicholas J. Silva, Christian Lagares-Linares, Ellen Y. Wang, Sunrae E. Taloma, Beatriz Cuevas, Hiromi Nakao-Inoue, Brianna M. Rivera, Bjoern Schwer, Carlo Condello, Raul Andino, Tomasz J. Nowakowski and […]


Continue.. A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis

B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates

Kavli Affiliate: Robert Edwards | Authors: Md. Alamgir Hossain, Kara Anasti, Brian Watts, Kenneth Cronin, Advaiti Pai Kane, R.J. Edwards, David Easterhoff, Jinsong Zhang, Wes Rountree, Yaneth Ortiz, Laurent Verkoczy, Michael Reth and S. Munir Alam | Summary: HIV-1 Envelope (Env) proteins designed to induce neutralizing antibody responses allow study of the role of affinities […]


Continue.. B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates