Kavli Affiliate: Michael Keiser | Authors: Parker Grosjean, Kaivalya Shevade, Cuong Nguyen, Sarah Ancheta, Karl Mader, Ivan Franco, Seok-Jin Heo, Greyson Lewis, Steven Boggess, Angelique De Domenico, Erik Ullian, Shawn Shafer, Adam Litterman, Laralynne Przybyla, Michael J Keiser, Jamie Ifkovits, Adam Yala and Martin Kampmann | Summary: High-throughput phenotypic screening has historically relied on manually […]

Kavli Affiliate: Yifan Cheng | Authors: Junrui Li, Yifei chen, Shawn Zheng, Angus McDonald, John W. Sedat, David A. Agard and Yifan Cheng | Summary: With technological advancements in recent years, single particle cryogenic electron microscopy (cryo-EM) has become a major methodology for structural biology. Structure determination by single particle cryo-EM is premised on randomly […]

Kavli Affiliate: Seth Shipman | Authors: Kazuo Nakamura, Karen Zhang, Mario R Mestre, Matias Rojas-Montero and Seth Shipman | Summary: Retrons are bacterial immune systems that protect a bacterial population against phages by killing infected hosts. Retrons typically comprise a reverse transcriptase, a template noncoding RNA that is partially reverse transcribed into RT-DNA, and a […]

Kavli Affiliate: Noelle L’Etoile | Authors: Zhijian Ji, Bingying Wang, Junqiang Liu, Rashmi K. Chandra, Winnie Yang, Yong Long, Michael Egan, Noelle L’Etoile and Dengke K. Ma | Summary: Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a […]

Kavli Affiliate: Robert Edwards | Authors: Parker J. Jamieson, Xiaoying Shen, Alexandra A. Abu-Shmais, Perry T. Wasdin, Katarzyna Janowska, Robert J. Edwards, Garrett Scapellato, Simone I. Richardson, Nelia P. Manamela, Shuying Liu, Maggie Barr, Rebecca A. Gillespie, Jessica Mimms, Naveenchandra Suryadevara, Ty A. Sornberger, Seth Zost, Rob Parks, Shelby Flaherty, Alexis K. Janke, Bethany N. […]

Kavli Affiliate: Arturo Alvarez-Buylla, Andrea Hasenstaub, and Michael Stryker | Authors: Benjamin Rakela, Jennifer Sun, Philine Marchetta, Arturo Alvarez-Buylla, Andrea R Hasenstaub and Michael P Stryker | Summary: Cortical interneurons play an important role in mediating the juvenile critical period for ocular dominance plasticity in the mouse primary visual cortex. Previously, we showed that transplantation […]

Kavli Affiliate: Saul Kato | Authors: Jason Adhinarta, Jizheng Dong, Tianxiao He, Daniel Sprague, JIa Wan, Hyun Jee Lee, Zikai Yu, Hang Lu, Eviatar Yemini, Saul Kato, Erdem Varol and Donglai Wei | Summary: The nematode C. elegans is a well-studied model organism for characterizing the structure, connectivity, and function of a complete nervous system. […]

Kavli Affiliate: Edward Chang | Authors: Matthew Elliott, John P. Andrews, Tjitse van der Molen, Jinghui Geng, Alex Spaeth, Anna Toledo, Kateryna Voitiuk, Cordero Core, Thomas Gillespie, Ari Sinervo, David F. Parks, Ash Robbins, Daniel Solis, Edward F. Chang, Tomasz J Nowakowski, Mircea Teodorescu, David Haussler and Tal Sharf | Summary: How seizures begin at […]

Kavli Affiliate: Michael Stryker | Authors: Luciano Dyballa, Greg D Field, Michael P Stryker and Steven W Zucker | Summary: A challenge in sensory neuroscience is understanding how populations of neurons operate in concert to represent diverse stimuli. To meet this challenge, we have created “encoding manifolds” that reveal the overall responses of brain areas […]

Kavli Affiliate: Andrea Hasenstaub | Authors: Timothy R Olsen and Andrea R Hasenstaub | Summary: Recent work has claimed that most apparently cross-modal responses in sensory cortex are instead caused by the face movements evoked by stimuli of the non-dominant modality. We show that visual stimuli rarely trigger face movements in awake mice; when they […]