Kavli Affiliate: Arnold R. Kriegstein | Authors: Beika Zhu, Andi Wangzhou, Diankun Yu, Tao Li, Rachael Schmidt, Stacy L. De Florencio, Lauren Chao, Yonatan Perez, Lea Tenenholz Grinberg, Salvatore Spina, Richard M Ransohoff, Arnold Kriegstein, William W Seeley, Tomasz J. Nowakowski and Xianhua Piao | Summary: Germline genetic architecture of Alzheimer’s disease (AD) indicates microglial […]

Kavli Affiliate: Edward Chang | Authors: Jeremy Saal, Ankit N. Khambhati, Edward F. Chang and Prasad Shirvalkar | Summary: Background Intracranial EEG (iEEG) is crucial for understanding brain function, but stimulation-induced noise complicates data interpretation. Traditional artifact detection methods require manual user input or struggle with noise variability, especially with limited labeled data. Objective We […]

Kavli Affiliate: Yifan Cheng | Authors: Mingliang Jin, Robert Seed, Tiffany Shing, Yifan Cheng and Stephen Nishimura | Summary: The multifunctional cytokine TGF-β is produced in a latent form (L-TGF-β) where a RGD containing homodimeric prodomain forms a “ring” encircling mature TGF-β shielding it from its receptors. Thus L-TGF-β must be activated to function, a […]

Kavli Affiliate: Zachary Knight | Authors: Heeun Jang, Alexis Behne Sharma, Usan Dan, Jasmine H. Wong, Zachary A. Knight and Jennifer L. Garrison | Summary: Chronic dehydration is a leading cause of morbidity for the elderly, but how aging alters the fluid homeostasis system is not well understood. Here, we used a combination of physiologic, […]

Kavli Affiliate: Devanand Manoli and Jeremy Willsey | Authors: Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt, Belinda Wang, Gina Williams, Shuyu Wang, Kara Quine, Rose D. Larios, Kimberly L. P. Long, Nerissa Hoglen, Bibi Alika Sulaman, Marie C. Heath, Michael Sherman, Matthew Kinkel, Angela Cai, Denis Galo, Lizandro Chan Caamal, Nastacia L. Goodwin, Annaliese Beery, […]

Kavli Affiliate: Michael Keiser | Authors: Sina Ghandian, Liane Albarghouthi, Kiana Nava, Shivam R. Rai Sharma, Lise Minaud, Laurel Beckett, Naomi Saito, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin, Brittany N. Dugger and Michael J. Keiser | Summary: Accumulation of abnormal tau protein into neurofibrillary tangles (NFTs) is a pathologic hallmark of […]

Kavli Affiliate: Joshua Berke and Loren Frank | Authors: Alison E. Comrie, Emily J. Monroe, Ari E. Kahn, Eric L. Denovellis, Abhilasha Joshi, Jennifer A. Guidera, Timothy A. Krausz, Joshua D. Berke, Nathaniel D. Daw and Loren M. Frank | Summary: Summary: The cognitive ability to go beyond the present to consider alternative possibilities, including […]

Kavli Affiliate: Keri Martinowich | Authors: Amber M Smith, Yang Li, Arianna Velarde, Yifan Cheng and Alan D. Frankel | Summary: Summary: Crm1 is a highly conserved nuclear exportin that transports >1000 human proteins including ribonucleoprotein (RNP) complexes. The interface between Crm1 and RNP cargos is unknown. The HIV regulatory protein, Rev, was one of […]

Kavli Affiliate: Michael Keiser | Authors: Mikio Tada, Garrett Gaskins, Sina Ghandian, Nicholas Mew, Michael J. Keiser and Elizabeth S. Keiser | Summary: Melanocytic atypia, ranging from benign to malignant, often leads to diagnostic discordance, complicating its prediction by machine learning models. To overcome this, we paired H&E-stained histology images with contiguous or serial sections […]

Kavli Affiliate: Reza Abbasi Asl and Philip Starr | Authors: Kara N Presbrey, Thomas A Wozny, Kenneth H Louie, Simon Little, Philip A Starr, Reza Abbasi-Asl and Doris D Wang | Summary: Learning fine motor sequences is crucial to quality of life and can be altered in Parkinson’s Disease (PD). It may be partially driven […]