Kavli Affiliate: Michael Keiser | Authors: Benjamin Orr, Stephanie E Crilly, Deniz Akpinaroglu, Eleanor Zhu, Michael J. Keiser and Tanja Kortemme | Summary: Nature uses structural variations on protein folds to fine-tune the geometries of proteins for diverse functions, yet deep learning-based de novo protein design methods generate highly regular, idealized protein fold geometries that […]
Kavli Affiliate: Arnold R. Kriegstein | Authors: Chujing Zhang, Eugene Gil, Sajad Hamid Ahanger, Mingcong Li, Li Wang, Eric J. Huang, Jingjing Li, Arnold R. Kriegstein and Daniel A. Lim | Summary: Approximately 30-40% of the human genome is anchored to the nuclear lamina (NL) through variably sized (10 kb-10 Mb) lamina-associated domains (LADs), which […]
Kavli Affiliate: Vikaas Sohal | Authors: Cesar P Canales, Stephanie Lozano, Nicholas A Frost, Karol Cichewicz, Wellington Amaral, Nicolas Seban, Ethan Fenton, Ayanna Wade, Nickolas Chu, Emily Smith, Cory Ardekani, Samuel Frank, Jeffrey Bennett, Pierre Lavenex, Aspen Kopley-Smith, Darlene Rahbarian, Melisa Corea, Daniela Perla, Liam Davis, Jiyuan Zhu, Rebecca Ortiz, Paris Beauregard, Caitlin Moyer, Jacob […]
Kavli Affiliate: Robert Edwards | Authors: Rumi Habib, Ryan S. Roark, Hui Li, Andrew Jesse Connell, Michael P. Hogarty, Kshitij Wagh, Shuyi Wang, Lorie Marchitto, Ashwin N. Skelly, John W. Carey, Kirsten J. Sowers, Kasirajan Ayyanathan, Samantha J. Plante, Frederic Bibollet-Ruche, Younghoon Park, Colby J. Agostino, Ajay Singh, Christian L. Martella, Emily Lewis, Jinery Lora, […]
Kavli Affiliate: Edward Chang | Authors: Youssef E Sibih, Abraham O Dada, Emily E Cunningham, Niels Olshausen, Jasleen Kaur, Velmurugan Jayabal, Sena Oten, Sanjeev Herr, Cesar N Gonzales, Andy Daniel, Saritha Krishna, Vardhaan S Ambati, Alexander A Aabedi, Gray Umbach, Kanish Mirchia, Poortata Lalwani, Edward F Chang, David R Raleigh, Srikantan Nagarajan, David Brang and […]
Kavli Affiliate: Reza Abbasi Asl | Authors: Julian A Wagner-Carena, Sai Kate, Trevor Riordan, Reza Abbasi-Asl, Joe Aman, Adam Amster, Agnes L Bodor, Derrick Brittain, JoAnn Buchanan, Michael A Buice, Daniel J Bumbarger, Forrest Collman, Nuno Macarico da Costa, Daniel J Denman, Saskia EJ de Vries, Emily Joyce, Dan Kapner, Chase W King, Josh D […]
Kavli Affiliate: Michael Stryker | Authors: Anna Lebedeva, Friedrich Kling, Benjamin Rakela, Michael P Stryker and Yujiao Jennifer Sun | Summary: Experience-dependent plasticity in the adult visual cortex is enhanced by locomotion, a process mediated by vasoactive intestinal peptide (VIP)-expressing interneurons. While VIP interneurons are known to signal through both Gamma-aminobutyric acid (GABA) and VIP […]
Kavli Affiliate: Alexandra Nelson | Authors: Rodrigo M Paz, Michael B Ryan, Pamela F Marcott, Allison E Girasole, Joseph Faryean, Vincent Duong, Sadhana Sridhar and Alexandra B Nelson | Summary: The use of levodopa to manage Parkinson’s disease (PD) symptoms leads to levodopa-induced dyskinesia (LID) and other motor fluctuations, which worsen with disease progression and […]
Kavli Affiliate: Hana El-Samad | Authors: Achal Mahajan, Francesca Ratti, Ban Wang, Hana El-Samad, James H. Kaufman and Vishrawas Gopalakrishnan | Summary: Regulation of gene expression is fundamental for proper cellular function, and is constrained by the local chromatin environment of each gene, which varies spatially along the chromosome and is shaped by epigenetic modifications. […]
Kavli Affiliate: Robert Edwards | Authors: Mera F. Liccione, Trevor Scobey, Heather M. Froggatt, Camryn Pajon, Boyd L. Yount, Qi Yin, Taylor N. Spence, Emmanuel B. Walter, Kevin O. Saunders, Robert J. Edwards, Ralph S. Baric, Barton F. Haynes, Derek W. Cain, Timothy P. Sheahan and Daniel Wrapp | Summary: HCoV-229E is an endemic Alphacoronavirus […]