Kavli Affiliate: Michael Keiser | Authors: William J. Connell, Kristle Garcia, Hani Goodarzi and Michael J. Keiser | Summary: Chemical probes interrogate disease mechanisms at the molecular level by linking genetic changes to observable traits. However, comprehensive chemical screens in diverse biological models are impractical. To address this challenge, we developed ChemProbe, a model that […]
Kavli Affiliate: Seth Shipman | Authors: Manuel Peter, Seth Shipman and Jeffrey D Macklis | Summary: Differentiation of human pluripotent stem cells (hPSC) into distinct neuronal populations holds substantial potential for disease modeling in vitro, toward both elucidation of pathobiological mechanisms and screening of potential therapeutic agents. For successful differentiation of hPSCs into subtype-specific neurons […]
Kavli Affiliate: Roger Nicoll | Authors: XIUMIN CHEN, Qixu Cai, jing zhou, Samuel J Pleasure, Howard Schulman, Mingjie Zhang and Roger A Nicoll | Summary: CaMKII plays a critical role in long-term potentiation (LTP), a well-established model for learning and memory through the enhancement of synaptic transmission. Biochemical studies indicate that CaMKII catalyzes a phosphotransferase […]
Kavli Affiliate: Robert Edwards | Authors: Sofia Dahlman, Laura Avellaneda-Franco, Ciaren Kett, Dinesh Subedi, Remy B Young, Jodee A. Gould, Emily L Rutten, Emily L Gilliver, Christopher JR Turkington, Neda Nezam-Abadi, Juris A Grasis, Dena Lyras, Professor, Robert A Edwards, Samuel C Forster and Jeremy J Barr | Summary: Large-scale metagenomic and data mining efforts […]
Kavli Affiliate: Yifan Cheng | Authors: Armin Adly, Maxine Bi, Christopher Carlson, Abdullah Muhammad Syed, Alison Ciling, Jennifer Doudna, Yifan Cheng and David O. Morgan | Summary: The Nucleocapsid (N) protein of SARS-CoV-2 compacts the RNA genome into viral ribonucleoprotein (vRNP) complexes within virions. Assembly of vRNPs is inhibited by phosphorylation of the N protein […]
Kavli Affiliate: Edward Chang, Karunesh Ganguly | Authors: NIKHILESH NATRAJ, Sarah Seko, Reza Abiri, Hongyi Yan, Yasmin Graham, Adelyn Tu-Chan, Edward F Chang and Karunesh Ganguly | Summary: The nervous system needs to balance the stability of neural representations with plasticity. It is unclear what is the representational stability of simple actions, particularly those that […]
Kavli Affiliate: Alexandra Nelson, Robert Edwards | Authors: Shweta Jain, Andrew G Yee, James Maas, Sarah Gierok, Hongfei Xu, Jasmine Stansil, Jacob Eriksen, Alexandra Nelson, Katlin Silm, Christopher P Ford and Robert H Edwards | Summary: The burst firing of midbrain dopamine neurons releases a phasic dopamine signal that mediates reinforcement learning. At many synapses, […]
Kavli Affiliate: Seth Shipman | Authors: Manuel Peter, Seth Shipman, Jeffrey D. Macklis | Summary: Differentiation of human pluripotent stem cells (hPSC) into distinct neuronal populations holds substantial potential for disease modeling in vitro, toward both elucidation of pathobiological mechanisms and screening of potential therapeutic agents. For successful differentiation of hPSCs into subtype-specific neurons using […]
Kavli Affiliate: Robert Edwards | Authors: Max Pearson, Carl Haslam, Andrew Fosberry, Emma J Jones, Mark Reglinski, Robert J Edwards, Richard Ashley Lawrenson, Jonathan C Brown, Danuta Mossakowska, James Edward Pease and Shiranee Sriskandan | Summary: The Streptococcus pyogenes cell envelope protease (SpyCEP) is vital to streptococcal pathogenesis and disease progression. Despite its strong association […]
Kavli Affiliate: Robert Edwards | Authors: Camille N. Pierre, Lily E. Adams, Kara Anasti, Derrick Goodman, Sherry Stanfield-Oakley, John M. Powers, Dapeng Li, Wes Rountree, Yunfei Wang, Robert J. Edwards, S. Munir Alam, Guido Ferrari, Georgia D. Tomaras, Barton F. Haynes, Ralph S. Baric and Kevin Saunders | Summary: Antibodies perform both neutralizing and non-neutralizing […]