The applicability of Regional Red List assessments for soil invertebrates: First assessment of five native earthworm species in Canada

Kavli Affiliate: John Reynolds | Authors: Helen R P Phillips, George Gardner Brown, Sam W. James, Jérôme Mathieu, John Warren Reynolds, Maheshi E Dharmasiri, Claire L. Singer, Maria J. I. Briones, Heather C. Procter and Erin K. Cameron | Summary: Summary: Earthworms (Annelida: Clitellata: Crassiclitellata) are prominent members of the soil community, important to many […]


Continue.. The applicability of Regional Red List assessments for soil invertebrates: First assessment of five native earthworm species in Canada

Intermittent Theta Burst Stimulation Drives Bi-Directional Changes in Excitability in Prefrontal Cortex

Kavli Affiliate: Jyoti Mishra and Dhakshin Ramanathan | Authors: Morteza Salimi, Milad Nazari, Jonathan Mishler, Jyoti Mishra and Dhakshin Ramanathan | Summary: Summary: Theta burst stimulation (TBS), an FDA-cleared treatment for depression, is hypothesized to modulate excitability in the prefrontal cortex, though this has not definitively been shown in vivo. We performed calcium imaging on […]


Continue.. Intermittent Theta Burst Stimulation Drives Bi-Directional Changes in Excitability in Prefrontal Cortex

Human rod photoreceptor outer segments are supported by accessory inner segment structures

Kavli Affiliate: Mark Ellisman | Authors: Tylor R Lewis, Natalia V Klementieva, Sebastien Phan, Carson M Castillo, Keun-Young Kim, Lauren Y Cao, Mark Ellisman, Vadim Y Arshavsky and Oleg Alekseev | Summary: The first steps in vision take place in photoreceptor cells, which are highly compartmentalized neurons exhibiting significant structural variation across species. The light-sensitive […]


Continue.. Human rod photoreceptor outer segments are supported by accessory inner segment structures

ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan

Kavli Affiliate: Mark Ellisman | Authors: Eric KF Donahue, Nathaniel L Hepowit, Brennen Keuchel, Alexandra G Mulligan, Derek J Johnson, Mark Ellisman, Rafael Arrojo e Drigo, Jason A MacGurn and Kristopher Burkewitz | Summary: The endoplasmic reticulum (ER) comprises an array of structurally distinct subdomains, each with characteristic functions. While altered ER-associated processes are linked […]


Continue.. ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan

Using phylogenetic summary statistics for epidemiological inference

Kavli Affiliate: Rafael Nunez | Authors: Rafael C Nunez, Gregory R Hart, Michael Famulare, Christopher Lorton and Joshua T Herbeck | Summary: Since the coining of the term phylodynamics, the use of phylogenies to understand infectious disease dynamics has steadily increased. As methods for phylodynamics and genomic epidemiology have proliferated and grown more computationally expensive, […]


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Synaptic Potentiation of Engram cells is Necessary and Sufficient for Context Fear Memory

Kavli Affiliate: Mark Mayford | Authors: Leonardo M Cardozo, Andre F Sousa, Blythe C Dillingham, Westley Dang, Nicholas Job, Eun J Yoo, Sural K Ranamukhaarachchi, Qi Yuan and Mark Mayford | Summary: The nature and distribution of the synaptic changes that underlie memory are not well understood. We examined the synaptic plasticity behind context fear […]


Continue.. Synaptic Potentiation of Engram cells is Necessary and Sufficient for Context Fear Memory

Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

Kavli Affiliate: V. S. Ramachandran | Authors: Nannan Wang, Franklin P. Ockerman, Laura Y. Zhou, Megan L Grove, Taryn Alkis, John Barnard, Russell P. Bowler, Clary B. Clish, Shinhye Chung, Emily Drzymalla, Anne M. Evans, Nora Franceschini, Robert E. Gerszten, Madeline G. Gillman, Scott R. Hutton, Rachel S. Kelly, Charles Kooperberg, Martin G. Larson, Jessica […]


Continue.. Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

A nuclear RNA degradation code for eukaryotic transcriptome surveillance

Kavli Affiliate: Angela Yu | Authors: Lindsey V Soles, Liang Liu, Xudong Zou, Yoseop Yoon, Shuangyu Li, Lusong Tian, Marielle Valdez, Angela Yu, Hong Yin, Wei Li, Fangyuan Ding, Georg Seelig, Lei Li and Yongsheng Shi | Summary: The RNA exosome plays critical roles in eukaryotic RNA degradation, but it remains unclear how the exosome […]


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Population responses to environmental stochasticity are primarily driven by survival-reproduction trade-offs and mediated by aridity

Kavli Affiliate: Gabriel Silva | Authors: Gabriel Silva Santos, Xianyu Yang, Samuel Gascoigne, Aldo Compagnoni, Andre Dias, Shripad D Tuljapurkar, Maja Kajin and Roberto Salguero-Gomez | Summary: Forecasting responses of natural populations to increasingly stochastic environments is a major challenge in Ecology and Conservation Biology. We now know that populations can modulate how their vital […]


Continue.. Population responses to environmental stochasticity are primarily driven by survival-reproduction trade-offs and mediated by aridity

A disinhibitory basal forebrain to cortex projection supports sustained attention

Kavli Affiliate: Edward Callaway | Authors: Shu-Jing Li, Balazs Hangya, Unmukt Gupta, Kyle B. Fischer, James Fitzhugh Sturgill, Edward M. Callaway and Adam Kepe | Summary: Sustained attention, as an essential cognitive faculty governing selective sensory processing, exhibits remarkable temporal fluctuations. However, the underlying neural circuits and computational mechanisms driving moment-to-moment attention fluctuations remain elusive. […]


Continue.. A disinhibitory basal forebrain to cortex projection supports sustained attention