Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study

Kavli Affiliate: Anders Dale | Authors: Xueying Chen, Hao Wang, Iris Broce, Anders M Dale, Bing Yu, Laura Y Zhou, Xihao Li, Maria Argos, Martha L Daviglus, Jianwen Cai, Nora Franceschini and Tamar Sofer | Summary: Hispanic/Latino populations are admixed, with genetic contributions from multiple ancestral populations. Studies of genetic association in these admixed populations […]


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Context-specific interaction of the lipid regulator DIP-2 with phospholipid synthesis in axon regeneration and maintenance.

Kavli Affiliate: Yishi Jin | Authors: Seungmee Park, Andrew D. Chisholm and Yishi Jin | Summary: Neurons maintain their morphology over prolonged periods of adult life with limited regeneration after injury. C. elegans DIP-2 is a conserved regulator of lipid metabolism that affects axon maintenance and regeneration after injury. Here, we investigated genetic interactions of […]


Continue.. Context-specific interaction of the lipid regulator DIP-2 with phospholipid synthesis in axon regeneration and maintenance.

Separable Dorsal Raphe Dopamine Projections mediate the Facets of Loneliness-like state

Kavli Affiliate: Kay Tye | Authors: Christopher R Lee, Gillian A Matthews, Mackenzie E Lemieux, Elizabeth M Wasserlein, Matilde Borio, Raymundo L Miranda, Laurel R Keyes, Gates P Schneider, Caroline Jia, Andrea Tran, Faith Aloboudi, May G Chan, Enzo Peroni, Grace Pereira, Alba López-Moraga, Anna Pall é, Eyal Y Kimchi, Nancy Padilla-Coreano, Romy Wichmann and […]


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Mental exploration of future choices during immobility theta oscillations

Kavli Affiliate: Jill Leutgeb | Authors: Mengni Wang, Li Yuan, Stefan Leutgeb and Jill K. Leutgeb | Summary: Mental exploration enables flexible evaluation of potential future choices, guiding decision-making without requiring direct real-world iterations. Although the hippocampus is known to be active while imagining the future, the precise mechanisms that support mental exploration of future […]


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Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

Kavli Affiliate: V. S. Ramachandran | Authors: Nannan Wang, Franklin P. Ockerman, Laura Y. Zhou, Megan L Grove, Taryn Alkis, John Barnard, Russell P. Bowler, Clary B. Clish, Shinhye Chung, Emily Drzymalla, Anne M. Evans, Nora Franceschini, Robert E. Gerszten, Madeline G. Gillman, Scott R. Hutton, Rachel S. Kelly, Charles Kooperberg, Martin G. Larson, Jessica […]


Continue.. Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

A brainstem map of orofacial rhythms

Kavli Affiliate: David Kleinfeld | Authors: Heet Kaku, Liu D Liu, Runbo Gao, Steven West, Song-Mao Liao, Arseny Finkelstein, David Kleinfeld, Alyse Thomas, Sri Laasya Tipparaju, Karel Svoboda and Nuo Li | Summary: Rhythmic orofacial movements, such as eating, drinking, or vocalization, are controlled by distinct premotor oscillator networks in the brainstem. Orofacial movements must […]


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Molecular Drivers of RNA Phase Separation

Kavli Affiliate: V. S. Ramachandran | Authors: Marc Turner, Sarah Robinson-Schwartz, Siavash Fazel Darbandi, John L.R. Rubenstein and Vikaas Singh Sohal | Summary: RNA molecules are essential in orchestrating the assembly of biomolecular condensates and membraneless compartments in cells. Many condensates form via the association of RNA with proteins containing specific RNA binding motifs. However, […]


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Atlas of plasma metabolic markers linked to human brain morphology

Kavli Affiliate: Anders Dale | Authors: Dennis van der Meer, Jakub Kopal, Alexey Shadrin, Julian Fuhrer, Jaroslav Rokicki, Sara Stinson, Srdjan Djurovic, Anders Dale and Ole Andreassen | Summary: Background Metabolic processes form the basis of the development, functioning and maintenance of the brain. Despite accumulating evidence of the vital role of metabolism in brain […]


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Characterisation of the axon initial segment and intrinsic excitability in the sub-acute phase post-ischemic stroke

Kavli Affiliate: John Reynolds | Authors: Emily S King, Jamie L Beros, Hakuei Fujiyama, John N Reynolds and Alexander D Tang | Summary: Background: Stroke is a leading cause of disability and stroke-induced changes in cortical excitability are thought to impede functional recovery. Identifying cellular targets that contribute to maladaptive excitability holds great potential for […]


Continue.. Characterisation of the axon initial segment and intrinsic excitability in the sub-acute phase post-ischemic stroke

The spinal premotor network driving scratching flexor and extensor alternation

Kavli Affiliate: Eiman Azim and Tatyana Sharpee | Authors: Mingchen Yao, Akira Nagamori, Eiman Azim, Tatyana Sharpee, Martyn Goulding, David Golomb and Graziana Gatto | Summary: Rhythmic motor behaviors are generated by neural networks termed central pattern generators (CPGs). Although locomotor CPGs have been extensively characterized, it remains unknown how the neuronal populations composing them […]


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