Kavli Affiliate: V. S. Ramachandran | Authors: Nannan Wang, Franklin P. Ockerman, Laura Y. Zhou, Megan L Grove, Taryn Alkis, John Barnard, Russell P. Bowler, Clary B. Clish, Shinhye Chung, Emily Drzymalla, Anne M. Evans, Nora Franceschini, Robert E. Gerszten, Madeline G. Gillman, Scott R. Hutton, Rachel S. Kelly, Charles Kooperberg, Martin G. Larson, Jessica […]

Kavli Affiliate: David Kleinfeld | Authors: Heet Kaku, Liu D Liu, Runbo Gao, Steven West, Song-Mao Liao, Arseny Finkelstein, David Kleinfeld, Alyse Thomas, Sri Laasya Tipparaju, Karel Svoboda and Nuo Li | Summary: Rhythmic orofacial movements, such as eating, drinking, or vocalization, are controlled by distinct premotor oscillator networks in the brainstem. Orofacial movements must […]

Kavli Affiliate: V. S. Ramachandran | Authors: Marc Turner, Sarah Robinson-Schwartz, Siavash Fazel Darbandi, John L.R. Rubenstein and Vikaas Singh Sohal | Summary: RNA molecules are essential in orchestrating the assembly of biomolecular condensates and membraneless compartments in cells. Many condensates form via the association of RNA with proteins containing specific RNA binding motifs. However, […]

Kavli Affiliate: John Reynolds | Authors: Emily S King, Jamie L Beros, Hakuei Fujiyama, John N Reynolds and Alexander D Tang | Summary: Background: Stroke is a leading cause of disability and stroke-induced changes in cortical excitability are thought to impede functional recovery. Identifying cellular targets that contribute to maladaptive excitability holds great potential for […]

Kavli Affiliate: Eiman Azim and Tatyana Sharpee | Authors: Mingchen Yao, Akira Nagamori, Eiman Azim, Tatyana Sharpee, Martyn Goulding, David Golomb and Graziana Gatto | Summary: Rhythmic motor behaviors are generated by neural networks termed central pattern generators (CPGs). Although locomotor CPGs have been extensively characterized, it remains unknown how the neuronal populations composing them […]

Kavli Affiliate: John Reynolds | Authors: Yan-Feng Zhang, Jean-Philippe Dufour, Peter Zatka-Haas, Peter Redgrave, Melony J Black, Armin Lak, Ed Mann, Stephanie J Cragg, Wickliffe Abraham and John NJ Reynolds | Summary: In classical Pavlovian conditioning, it is well-established that midbrain dopamine neurons respond to conditioned stimuli (CS) that predict a reward. However, how the […]

Kavli Affiliate: Takaki Komiyama | Authors: An Wu, Qiyu Chen, Bin Yu, Soyoung Chae, Zijing Tan, Assaf Ramot and Takaki Komiyama | Summary: During the execution of learned motor skills, the neural population in the layer 2/3 (L2/3) of the primary motor cortex (M1) expresses a reproducible spatiotemporal activity pattern. It is debated whether M1 […]

Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B Kennedy | Summary: Long-term potentiation (LTP) is a biochemical process that underlies learning in excitatory glutamatergic synapses in the Central Nervous System (CNS). The critical early driver of LTP is autophosphorylation of the abundant postsynaptic enzyme, […]

Kavli Affiliate: Eiman Azim | Authors: Jake Lustig, Alexander Lammers, Julia Kaiser, Payal Patel, Aidan Raghu, James M. Conner, Phong Nguyen, Eiman Azim and Vibhu Sahni | Summary: The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPN) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular delineation […]