Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State

Kavli Affiliate: Kay Tye | Authors: Christopher R Lee, Gillian A Matthews, Mackenzie E Lemieux, Elizabeth M Wasserlein, Matilde Borio, Raymundo L Miranda, Laurel R Keyes, Gates P Schneider, Caroline Jia, Andrea Tran, Faith Aloboudi, May G Chan, Enzo Peroni, Grace Pereira, Alba López-Moraga, Anna Pallé, Eyal Y Kimchi, Nancy Padilla-Coreano, Romy Wichmann and Kay […]


Continue.. Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State

Synaptic Spine Head Morphodynamics from Graph Grammar Rules for Actin Dynamics

Kavli Affiliate: Terrence Sejnowski | Authors: Matthew Hur, Thomas Bartol, Padmini Rangamani, Terrence Sejnowski and Eric Mjolsness | Summary: There is a morphodynamic component to synaptic learning by which changes in dendritic (postsynaptic) spine head size are associated with the strengthening or weakening of the synaptic connection between two neurons, in response to the temporal […]


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Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

Kavli Affiliate: Seth Shipman Eiman Azim | Authors: Abdulkadir Ozkan, Hari K Padmanabhan, Seth Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, Nazli Basak and Jeffrey D Macklis | Summary: Corticospinal neurons (CSN) centrally degenerate in amyotrophic lateral sclerosis (ALS), along with spinal motor neurons, and loss of voluntary motor function in spinal cord injury (SCI) […]


Continue.. Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

Glutamate indicators with increased sensitivity and tailored deactivation rates

Kavli Affiliate: David Kleinfeld | Authors: Abhi Aggarwal, Adrian Negrean, Yang Chen, Rishyashring Iyer, Daniel Reep, Anyi Liu, Anirudh Palutla, Michael E Xie, Bryan MacLennan, Kenta M Hagihara, Lucas W Kinsey, Julianna L Sun, Pantong Yao, Jihong Zheng, Arthur Tsang, Getahun Tsegaye, Yonghai Zhang, Ronak H Patel, Benjamin J Arthur, Julien Hiblot, Philipp Leippe, Miroslaw […]


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Long-term editing of brain circuits in mice using an engineered electrical synapse

Kavli Affiliate: Kay Tye | Authors: Elizabeth Ransey, Gwenaëlle Thomas, Elias Wisdom, Agustin Almoril-Porras, Ryan Bowman, Elise Adamson, Kathryn K Walder-Christensen, Jesse A White, Dalton N Hughes, Hannah Schwennesen, Caly Ferguson, Kay Tye, Stephen D Mague, Long-Gang Niu, Zhao-Wen Wang, Daniel Colón-Ramos, Rainbo Hultman, Nenad Bursac and Kafui Dzirasa | Summary: Electrical signaling across distinct […]


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Neural Mechanisms Linking Global Maps to First-Person Perspectives

Kavli Affiliate: Douglas Nitz | Authors: Hin Wai Lui, Elizabeth R. Chrastil, Douglas A. Nitz and Jeffrey L. Krichmar | Summary: Humans and many animals possess the remarkable ability to navigate environments by seamlessly switching between first-person perspectives (FPP) and global map perspectives (GMP). However, the neural mechanisms that underlie this transformation remain poorly understood. […]


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Differential glutamatergic and GABAergic responses drive divergent prefrontal cortex neural outcomes to low and high frequency stimulation

Kavli Affiliate: Jyoti Mishra and Dhakshin Ramanathan | Authors: Morteza Salimi, Milad Nazari, Jonathan Mishler, Mishra Jyoti and Dhakshin Ramanathan | Summary: Background Repetitive brain stimulation is hypothesized to bidirectionally modulate excitability, with low-frequency trains decreasing and high-frequency (>5 Hz) trains increasing activity. Most insights on the neuroplastic effects of repetitive stimulation protocols stem from […]


Continue.. Differential glutamatergic and GABAergic responses drive divergent prefrontal cortex neural outcomes to low and high frequency stimulation

Single Objective Light Sheet Microscopy allows high-resolution in vivo brain imaging of Drosophila.

Kavli Affiliate: Mark Ellisman | Authors: Francisco Joaquín Tassara, Mariano Barella, Lourdes Simó, Mailen Folgueira, Micaela Rodríguez-Caron, Juan Ignacio Ispizua, Mark H. Ellisman, Horacio O. de la Iglesia, M. Fernanda Ceriani and Julián Gargiulo | Summary: In vivo imaging of dynamic sub-cellular brain structures in Drosophila melanogaster is key to understanding several phenomena in neuroscience. […]


Continue.. Single Objective Light Sheet Microscopy allows high-resolution in vivo brain imaging of Drosophila.

Daily ultrastructural remodeling of clock neurons

Kavli Affiliate: Mark Ellisman | Authors: Juan I. Ispizua, Micaela Rodriguez-Caron, Francisco J. Tassara, Kim Keun-young, Catalina Insusarry Perkins, Milagros Barzi, Christian Carpio-Romero, Celia N. Hansen, Julian Gargiulo, Ezio Rosato, Horacio de la iglesia, Mark Ellisman and M. Fernanda Ceriani | Summary: In Drosophila, about 250 clock neurons in the brain form a network that […]


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Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice

Kavli Affiliate: Takaki Komiyama | Authors: Sonja Blumenstock, David Arakelyan, Nicholas del Grosso, Sonja Schneider, Yufeng Shao, Enida Gjoni, Ruediger Klein, Irina Dudanova and Takaki Komiyama | Summary: Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral […]


Continue.. Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice