Developmental variation in dopamine neurobiology, neurocognitive functioning, and impulsivity shape substance use trajectories in youth

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Ashley Clare Parr, Amar Ojha, Daniel Petrie, Finnegan Calabro, Brenden Tervo-Clemmens, Will Foran, Douglas Fitzgerald, Susan Tapert, Kate Nooner, Wesley Thompson, David Goldston, Duncan Clark and Beatriz Luna | Summary: Theoretical neurodevelopmental models implicate increases in dopamine (DA) function and limitations in neurocognitive control in risk-taking behavior, including substance […]


Continue.. Developmental variation in dopamine neurobiology, neurocognitive functioning, and impulsivity shape substance use trajectories in youth

Memory recall errors reflect interacting sensory and mnemonic representations

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: John Serences | Authors: Holly Kular and John Serences | Summary: Visual working memory (WM) enables the maintenance of information that is no longer present in the environment. Some accounts propose that WM is supported by abstract representations so that new sensory inputs do not interfere with existing memories. Others posit that early […]


Continue.. Memory recall errors reflect interacting sensory and mnemonic representations

A genetically-defined population of amygdalofugal neurons promotes suckling and early postnatal growth

Posted by dbos UCSD / Salk

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Samuel Pfaff | Authors: Jeffrey Moore, Lukas Bachmann, Lauren McElvain, Samuel Pfaff and Catherine Dulac | Summary: Suckling by newborns is an instinctive behavior defining the mammalian class. Yet, due to experimental difficulty in assessing neural function in the very […]


Continue.. A genetically-defined population of amygdalofugal neurons promotes suckling and early postnatal growth

Primate ACC encodes natural vocal interactions in a cocktail party

Posted by dbos UCSD / Salk

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Cory Miller | Authors: Arthur Lefevre, Vikram Pal Singh, Timothy Tyree, Jingwen Li, Jean-Rene Duhamel and Cory Miller | Summary: The Cocktail Party Problem (CPP) – extracting meaningful signals amid competing voices – remains poorly understood at the neural level, […]


Continue.. Primate ACC encodes natural vocal interactions in a cocktail party

Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation

Posted by dbos UCSD / Salk

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Angela Yu | Authors: Samantha E. Koplik, Angela M Yu, Madelyn R. Shelby, Gabriel C. Fonseca, Charles M. Roco, Yue Zhang, Nicholas Bogard, Alex K. Sabo, Alexander B. Rosenberg, Johannes Linder and Georg Seelig | Summary: Splice-disrupting variants (SDVs) underlie […]


Continue.. Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation

Astrocyte SEMA3C reduction improves Rett Syndrome phenotypes

Posted by dbos UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: Krissy A Lyon, Adrien Paumier, Ananya Kandikonda, Andrea Melendez and Nicola J Allen | Summary: During typical neurodevelopment, astrocytes secrete proteins that support neuronal connectivity. This process is disrupted in Rett Syndrome (RTT), a regressive neurodevelopmental disorder characterized by motor, sensory, and cognitive impairments. While astrocytes typically promote neuron […]


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Cerebellar outputs for rapid directional refinement of forelimb movement

Posted by dbos UCSD / Salk

Kavli Affiliate: Eiman Azim | Authors: Ayesha R. Thanawalla, Oren Wilcox, Eliza Rhee, Juan Jiang, Kee Wui Huang, Raihana Yusufi, Dalia Saklaway, Akira Nagamori, James M. Conner, Albert I. Chen and Eiman Azim | Summary: Much of our interaction with the world relies on the ability to move our limbs with speed and precision. The […]


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The effect of Sinorhizobium meliloti volatilomes and synthetic long-chain methylketones on soil and Medicago truncatula microbiomes

Posted by dbos UCSD / Salk

Kavli Affiliate: Rafael Nunez | Authors: Pieter van Dillewijn, Lydia M. Bernabéu-Roda, Virginia Cuéllar, Rafael Núñez, Otto Geiger, Isabel M. López-Lara and María J. Soto | Summary: Bacterial volatile compounds play important roles in intra- and interkingdom interactions but very little is known about their effects on soil and plant microbiomes. The legume symbiont Sinorhizobium […]


Continue.. The effect of Sinorhizobium meliloti volatilomes and synthetic long-chain methylketones on soil and Medicago truncatula microbiomes

Flexible gaze reinstatement during working memory for natural scenes

Posted by dbos UCSD / Salk

Kavli Affiliate: Anastasia Kiyonaga | Authors: Yueying Dong, Yunchen Hung, Lana Gaspariani and Anastasia Kiyonaga | Summary: Working memory (WM) representations may be more action-oriented and anatomically widespread than previously assumed. For instance, oculomotor signatures like gaze biases can reflect spatial WM content. However, the specificity and functional relevance of such signatures is unclear. Here, […]


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Multiscale Hyperbolic Embedding for Cell Hierarchies in Large-Scale Bioinformatics Data

Posted by dbos UCSD / Salk

Kavli Affiliate: Tatyana Sharpee | Authors: Mingchen Yao, Anoop Praturu and Tatyana Sharpee | Summary: The increasing size of datasets poses challenges for their visualization and interpretation, highlighting the need for scalable and effective analysis methods. Hyperbolic embedding have shown strong potential in capturing complex hierarchical structures across diverse systems. However, existing hyperbolic embedding methods […]


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