Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Jeziel D Damasceno, Gabriel LA Silva, Catarina A Marques, Marija Krasilnikova, Craig Lapsley, Dario Beraldi and Richard McCulloch | Summary: Understanding genome duplication requires characterisation of the locations where DNA replication initiates, termed origins. Genome-wide mapping of DNA replication origins has mainly been derived from population-based techniques, with only […]


Continue.. Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events

Ultrastructural correlates of circadian structural plasticity

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Juan I. Ispizua, Micaela Rodriguez-Caron, Francisco J. Tassara, Kim Keun-young, Catalina Insusarry Perkins, Milagros Barzi, Christian Carpio-Romero, Celia N. Hansen, Julian Gargiulo, Ezio Rosato, Horacio de la iglesia, Mark Ellisman and M. Fernanda Ceriani | Summary: The central clock in the Drosophila’s brain consists of approximately 250 neurons organized […]


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Single Objective Light Sheet Microscopy allows high-resolution in vivo brain imaging of Drosophila

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Francisco Joaquín Tassara, Mariano Barella, Lourdes Simó, Mailen Folgueira, Micaela Rodríguez-Caron, Juan Ignacio Ispizua, Mark H. Ellisman, Horacio O. de la Iglesia, M. Fernanda Ceriani and Julián Gargiulo | Summary: In vivo imaging of dynamic sub-cellular brain structures in Drosophila melanogaster is key to understanding several phenomena in neuroscience. […]


Continue.. Single Objective Light Sheet Microscopy allows high-resolution in vivo brain imaging of Drosophila

Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

Posted by dbos Columbia, UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Song-Yi Lee, Heegwang Roh, David Gonzalez-Perez, Mason R Mackey, Keun-Young Kim, Daniel Hoces, Colleen McLaughlin, Stephen R Adams, Khanh Nguyen, David J Luginbuhl, Liqun Luo, Namrata Udeshi, Steven A Carr, Rogelio A Hernandez-Lopez, Mark Ellisman, Miguel Alcalde and Alice Y Ting | Summary: Enzymes that oxidize aromatic substrates have […]


Continue.. Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

Discovering Cognitive Strategies with Tiny Recurrent Neural Networks

Posted by dbos UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Li Ji-An, Marcus K Benna and Marcelo G Mattar | Summary: Normative modeling frameworks such as Bayesian inference and reinforcement learning provide valuable insights into the fundamental principles governing adaptive behavior. While these frameworks are valued for their simplicity and interpretability, their reliance on few parameters often limits their […]


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Like mother, like daughter? Phenotypic plasticity, environmental covariation, and heritability of size in a parthenogenetic wasp

Posted by klaurent UCSD / Salk

Kavli Affiliate: William Kristan | Authors: Alicia Tovar, Scott Monahan, Adrian Kristan, Walker Welch, Ryan Dettmers, Camila Arce, Theresa Buck, Michele Ruben, Alexander Rothenberg, Roxane Saisho, Ryan Cartmill, Timothy Skaggs, Robert Reyes, MJ Lee, John J Obrycki, William Kristan and Arun Sethuraman | Summary: Abstract Dinocampus coccinellae (Hymenoptera:Braconidae, Euphorinae) is a solitary, generalist Braconid parasitoid […]


Continue.. Like mother, like daughter? Phenotypic plasticity, environmental covariation, and heritability of size in a parthenogenetic wasp

Brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

Posted by dbos Hopkins, UCSD / Salk

Kavli Affiliate: Timothy Brown and Richard Huganir | Authors: Boaz Mohar, Gabriela Michel, Yi-Zhi Wang, Veronica Hernandez, Jonathan B. Grimm, Jin-Yong Park, Ronak Patel, Morgan Clarke, Timothy A. Brown, Cornelius Bergmann, Kamil K. Gebis, Anika P. Wilen, Bian Liu, Ricard Johnson, Austin Graves, Tatjana Tchumatchenko, Jeffrey N. Savas, Eugenio F. Fornasiero, Richard L. Huganir, Paul […]


Continue.. Brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

Nucleoprotein phase-separation affinities revealed via atomistic simulations of short peptide and RNA fragments

Posted by dbos UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Vysakh Ramachandran, William Brown and Davit A Potoyan | Summary: Liquid-liquid phase separation of proteins and nucleic acids into condensate phases is a versatile mechanism for ensuring compartmentalization of cellular biochemistry. RNA molecules play critical roles in these condensates, particularly in transcriptional regulation and stress responses, exhibiting a […]


Continue.. Nucleoprotein phase-separation affinities revealed via atomistic simulations of short peptide and RNA fragments

Disparate demographic impacts of the Roman Colonization and the Migration Period in the Iberian Peninsula

Posted by dbos UCSD / Salk

Kavli Affiliate: Jose Ricardo Suarez | Authors: Pablo Carrion, Inigo Olalde, Juan Manuel Jimenez-Arenas, Neus Coromina, David Vivo, Josep Maria Verges, Ana Costa, Daniel Botella, Macarena Bustamante-Alvarez, Javier Heras-Mora, Ricardo Ortega-Ruiz, Celia Chaves, Maite Iris Garcia-Collado, Juan Quiros-Castillo, Jordi Roig, Jose Suarez-Padilla, Ildelfonso Navarro-Luengo, Miguel Angel Cuadrado, Isidro Aguilera, Jordi Morera, Raul Catalan, Maria Luisa […]


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High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes

Posted by dbos UCSD / Salk

Kavli Affiliate: Edward Callaway | Authors: Li Alex Zhang, Peichao Li and Edward M. Callaway | Summary: Summary: Laminar electrode arrays allow simultaneous recording of activity of many cortical neurons and assignment to layers using current source density (CSD) analyses. Electrode arrays with 100-micron contact spacing have been used to estimate borders between layer 4 […]


Continue.. High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes