Characterisation of the axon initial segment and intrinsic excitability in the sub-acute phase post-ischemic stroke

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Emily S King, Jamie L Beros, Hakuei Fujiyama, John N Reynolds and Alexander D Tang | Summary: Background: Stroke is a leading cause of disability and stroke-induced changes in cortical excitability are thought to impede functional recovery. Identifying cellular targets that contribute to maladaptive excitability holds great potential for […]


Continue.. Characterisation of the axon initial segment and intrinsic excitability in the sub-acute phase post-ischemic stroke

The spinal premotor network driving scratching flexor and extensor alternation

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Eiman Azim and Tatyana Sharpee | Authors: Mingchen Yao, Akira Nagamori, Eiman Azim, Tatyana Sharpee, Martyn Goulding, David Golomb and Graziana Gatto | Summary: Rhythmic motor behaviors are generated by neural networks termed central pattern generators (CPGs). Although locomotor CPGs have been extensively characterized, it remains unknown how the neuronal populations composing them […]


Continue.. The spinal premotor network driving scratching flexor and extensor alternation

The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning

Posted by dbos UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Yan-Feng Zhang, Jean-Philippe Dufour, Peter Zatka-Haas, Peter Redgrave, Melony J Black, Armin Lak, Ed Mann, Stephanie J Cragg, Wickliffe Abraham and John NJ Reynolds | Summary: In classical Pavlovian conditioning, it is well-established that midbrain dopamine neurons respond to conditioned stimuli (CS) that predict a reward. However, how the […]


Continue.. The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning

Targeted stimulation of motor cortex neural ensembles drives learned movements

Posted by dbos UCSD / Salk

Kavli Affiliate: Takaki Komiyama | Authors: An Wu, Qiyu Chen, Bin Yu, Soyoung Chae, Zijing Tan, Assaf Ramot and Takaki Komiyama | Summary: During the execution of learned motor skills, the neural population in the layer 2/3 (L2/3) of the primary motor cortex (M1) expresses a reproducible spatiotemporal activity pattern. It is debated whether M1 […]


Continue.. Targeted stimulation of motor cortex neural ensembles drives learned movements

A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping.

Posted by dbos UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B Kennedy | Summary: Long-term potentiation (LTP) is a biochemical process that underlies learning in excitatory glutamatergic synapses in the Central Nervous System (CNS). The critical early driver of LTP is autophosphorylation of the abundant postsynaptic enzyme, […]


Continue.. A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping.

Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity

Posted by dbos UCSD / Salk

Kavli Affiliate: Eiman Azim | Authors: Jake Lustig, Alexander Lammers, Julia Kaiser, Payal Patel, Aidan Raghu, James M. Conner, Phong Nguyen, Eiman Azim and Vibhu Sahni | Summary: The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPN) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular delineation […]


Continue.. Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity

Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

Posted by dbos UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Erin M Ritchie, Siming Zhong, Qianyi Pu, Yunbo Li, Binhai Zheng and Yishi Jin | Summary: The conserved MAP3K12/Dual Leucine Zipper Kinase (DLK) plays versatile roles in neuronal development, axon injury and stress responses, and neurodegeneration, depending on cell-type and cellular contexts. Emerging evidence implicates abnormal DLK signaling in […]


Continue.. Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

How much is ‘enough’? Considerations for functional connectivity reliability in pediatric naturalistic fMRI

Posted by dbos UCSD / Salk

Kavli Affiliate: Deanna J. Greene and Jeremy Willsey | Authors: Shefali S. Rai, Kate J. Godfrey, Kirk Graff, Ryann Tansey, Daria Merrikh, Shelly Yin, Matthew Feigelis, Damion V. Demeter, Tamara Vanderwal, Deanna J. Greene and Signe L. Bray | Summary: functional connectivity (FC) measurements are important for robust and reproducible findings, yet pediatric functional magnetic […]


Continue.. How much is ‘enough’? Considerations for functional connectivity reliability in pediatric naturalistic fMRI

Active vision in freely moving marmosets using head-mounted eye tracking

Posted by dbos UCSD / Salk

Kavli Affiliate: Cory Miller | Authors: Vikram Pal Singh, Jingwen Li, Jude Mitchell and Cory Miller | Summary: Our understanding of how vision functions as primates actively navigate the real-world is remarkably sparse. As most data have been limited to chaired and typically head-restrained animals, the synergistic interactions of different motor actions/plans inherent to active […]


Continue.. Active vision in freely moving marmosets using head-mounted eye tracking

Inter- and Intrahemispheric Sources of Vestibular Signals to V1

Posted by dbos UCSD / Salk

Kavli Affiliate: Massimo Scanziani | Authors: Guy Bouvier, Alessandro Sanzeni, Elizabeth Hamada, Nicolas Brunel and Massimo Scanziani | Summary: Head movements are sensed by the vestibular organs. Unlike classical senses, signals from vestibular organs are not conveyed to a dedicated cortical area but are broadcast throughout the cortex. Surprisingly, the routes taken by vestibular signals […]


Continue.. Inter- and Intrahemispheric Sources of Vestibular Signals to V1