Deep Learning Improves Parameter Estimation in Reinforcement Learning Models

Kavli Affiliate: Marcelo Mattar | Authors: Hua-Dong Xiong, Li Ji-An, Marcelo G Mattar and Robert C Wilson | Summary: Cognitive modeling provides a formal method to articulate and test hypotheses about cognitive processes. However, accurately and reliably estimating model parameters remains challenging due to common issues in behavioral science, such as limited data, measurement noise, […]


Continue.. Deep Learning Improves Parameter Estimation in Reinforcement Learning Models

Development of a Charge-Resistant Embedding Media for High-Performance Serial Block Face Imaging of Cells and Tissues

Kavli Affiliate: Mark Ellisman | Authors: Thomas Deerinck, Steven Peltier and Mark Ellisman | Summary: Serial block-face scanning electron microscopy (SBEM) enables high-resolution 3D imaging of biological specimens but is often limited by specimen charging due to the use of non-conductive epoxy resins. While heavy metal staining and variable-pressure SEM can reduce charging, these methods […]


Continue.. Development of a Charge-Resistant Embedding Media for High-Performance Serial Block Face Imaging of Cells and Tissues

Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

Kavli Affiliate: Mark Ellisman | Authors: Jonathan Choy, Shadi Charara, Kalyani Cauwenberghs, Quintyn McKaughan, Keun-Young Kim, Mark Ellisman and Chih-Ying Su | Summary: Dendritic morphology is a defining characteristic of neuronal subtypes. In Drosophila, heterotypic olfactory receptor neurons (ORNs) expressing different receptors display diverse dendritic morphologies, but whether such diversity exists among homotypic ORNs remains […]


Continue.. Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

Optimized Theta Burst Stimulation with Extended Intervals Enhances Excitatory-Inhibitory Balance

Kavli Affiliate: Dhakshin Ramanathan and Jyoti Mishra | Authors: Morteza Salimi, Milad Nazari, Jonathan Mishler, Jennifer Rodger, Sahar Jomehpour, Jyoti Mishra and Dhakshin Ramanathan | Summary: Varying inter-train intervals (ITIs) during theta burst stimulation (TBS) differentially modulates neuronal activity in the medial prefrontal cortex. Short ITIs (e.g., ITI 4 s) induce strong glutamatergic excitation but […]


Continue.. Optimized Theta Burst Stimulation with Extended Intervals Enhances Excitatory-Inhibitory Balance

Neuroticism Heterogeneity Through Item-Level Associations in Resting-State Functional Connectivity

Kavli Affiliate: Wesley Thompson | Authors: Masaya Misaki, Chun Chieh Fan, Wesley K Thompson, Heekyeong Park, Bohan Xu and Martin M Paulus | Summary: Neuroticism is characterized by emotional instability and increased susceptibility to stress-related disorders. While traditionally treated as a unitary construct, growing evidence suggests that neuroticism is heterogeneous in both its genetic basis […]


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FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets

Kavli Affiliate: Anders Dale and Wesley Thompson | Authors: Pravesh Parekh, Nadine Parker, Diliana Pecheva, Evgeniia Frei, Marc Vaudel, Diana M. Smith, Alison Rigby, Piotr Jahołkowski, Ida Elken Sønderby, Viktoria Birkenæs, Nora Refsum Bakken, Chun Chieh Fan, Carolina Makowski, Jakub Kopal, Robert John Loughnan, Donald J. Hagler, Jr., Dennis van der Meer, Stefan Johansson, Pål […]


Continue.. FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets

Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

Kavli Affiliate: Kay Tye | Authors: Caroline Jia, Andrea Tran, Faith Aloboudi, Ella Say, Nick Thao, Christopher R. Lee, Kanha Batra, Amanda Nguyen, Aneesh Bal, Nathaniel N. Nono, Jeremy Delahanty, May G Chan, Laurel R. Keyes, Reesha R. Patel, Romy Wichmann, Felix Taschbach, Yulong Li, Marcus K. Benna, Talmo D Pereira, Hao Li and Kay […]


Continue.. Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding

Kavli Affiliate: Tatyana Sharpee and Sreekanth Chalasani | Authors: Iulia Rusu, Zachary T Cecere, Javier J How, Kathleen T Quach, Eviatar Yemini, Tatyana O Sharpee and Sreekanth H Chalasani | Summary: Neurons represent changes in external and internal environments by altering their activity patterns. While coherent brain-wide patterns of neural activity have been observed in […]


Continue.. A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding

Seizure-induced Transient Disruptive Changes in Brain Microstructure

Kavli Affiliate: Anders Dale | Authors: Akihiro Takamiya, Frank Riemer, Vera Jane Erchinger, Max Korbmacher, Hauke Bartsch, Olga Therese Ousdal, Ivan Maximov, Anders Dale, Louise Emsell, Ketil Joachim Oedegaard, Ute Kessler and Leif Oltedal | Summary: A leading hypothesis for the mechanisms of electroconvulsive therapy (ECT) posits an initial disruptive effect followed by enhanced neuroplasticity. […]


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Presynaptic vesicles supply membrane for axonal bouton enlargement during LTP

Kavli Affiliate: Terrence Sejnowski | Authors: Patrick Leavey, Lizhi Jiang, Nicole Pannullo, Clayton Santiago and Seth BlackshawLyndsey M Kirk, Guadalupe C Garcia, Dakota C Hanka, Kyle Zatyko, Thomas M Bartol, Terrence J Sejnowski and Kristen M. Harris | Summary: Long-term potentiation (LTP) induces presynaptic bouton enlargement and a reduction in the number of synaptic vesicles. […]


Continue.. Presynaptic vesicles supply membrane for axonal bouton enlargement during LTP