Kavli Affiliate: Mary E. Hatten, C. David Allis | Authors: Lijuan Feng, Douglas Barrows, Liangwen Zhong, Kart Matlik, Elizabeth G. Porter, Annaelle M. Djomo, Iris Yau, Alexey A. Soshnev, Thomas S. Carroll, Duancheng Wen, Mary E. Hatten, Benjamin A. Garcia and C. David Allis | Summary: Chromatin is a crucial regulator of gene expression and […]
Kavli Affiliate: Charles M. Rice | Authors: Shira Weingarten-Gabbay, Matthew R Bauer, Alexandra C Stanton, Susan Klaeger, Eva K Verzani, Daniel Lopez, Karl R Clauser, Steven A Carr, Jennifer G Abelin, Charles M Rice and Pardis C Sabeti | Summary: Unveiling the complete proteome of viruses is crucial to our understanding of the viral life […]
Kavli Affiliate: Charles M. Rice | Authors: Zakary S. Singer, Jonathan Pabon, Hsinyen Huang, Charles M. Rice and Tal Danino | Summary: The ability of bacteria and viruses to selectively replicate in tumors has led to synthetic engineering of new microbial therapies. Here we design a cooperative strategy whereby S. typhimurium bacteria transcribe and deliver […]
Kavli Affiliate: Charles M. Rice | Authors: Kunihiro Uryu, Nadine Soplop, Timothy P Sheahan, Maria-Teresa Catanese, Chuong Huynh, John Pena, Nancy Boudreau, Irina Matei, Candia Kenific, Ayako Hashimoto, Ayuko Hoshino, Charles M Rice and David Lyden | Summary: Scanning electron microscopy (SEM) offers an unparalleled view of the membrane topography of mammalian cells by using […]
Kavli Affiliate: Winrich Freiwald | Authors: Farid Aboharb, Stephen Serene, Julia Sliwa and Winrich A Freiwald | Summary: In the primate brain the frontal lobes support complex functions, including social cognition. Understanding the functional organization of these regions requires an approach for rich functional characterization. Here we used a novel paradigm, the visual exploration of […]
Kavli Affiliate: Vanessa Ruta | Authors: Rory T Coleman, Ianessa Morantte, Gabriel T Koreman, Megan L Cheng, Yun Ding and Vanessa Ruta | Summary: Identifying a mate is a central imperative for males of most species but poses the challenge of distinguishing a suitable partner from an array of potential male competitors or females of […]
Kavli Affiliate: Alipasha Vaziri, Jeffrey M. Friedman | Authors: Bowen Tan, Caleb J Browne, Tobias Nobauer, Alipasha Vaziri, Jeffrey M. Friedman and Eric J. Nestler | Summary: Addiction prioritizes drug use over innate needs by hijacking brain circuits that direct motivation, but how this develops remains unclear. Using whole-brain FOS mapping and in vivo single-neuron […]
Kavli Affiliate: Cori Bargmann | Authors: Elias Scheer and Cori Bargmann | Summary: Foraging animals optimize feeding decisions by adjusting both common and rare behavioral patterns. Here, we characterize the relationship between an animal’s arousal state and a rare decision to leave a patch of bacterial food. Using long-term tracking and behavioral state classification, we […]
Kavli Affiliate: Roderick MacKinnon | Authors: Maria Elizabeth Falzone and Roderick MacKinnon | Summary: PLCβ enzymes cleave PIP2 producing IP3 and DAG. PIP2 modulates the function of many ion channels, while IP3 and DAG regulate intracellular Ca2+ levels and protein phosphorylation by protein kinase C, respectively. PLCb enzymes are under the control of GPCR signaling […]
Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Jonathan S Marvin, Alexandros C Kokotos, Mukesh Kumar, Camila Pulido, Ariana N Tkachuk, Jocelyn Shuxin Yao, Timothy A Brown and Timothy A Ryan | Summary: We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in subcellular […]