A green lifetime biosensor for calcium that remains bright over its full dynamic range

Kavli Affiliate: Gaby Maimon | Authors: Franka H. van der Linden, Stephen C. Thornquist, Rick M. ter Beek, Jelle Y. Huijts, Mark A. Hink, Theodorus W.J. Gadella, Jr., Gaby Maimon and Joachim Goedhart | Summary: Fluorescent biosensors toggle between two states and for the vast majority of biosensors one state is bright and the other […]


Continue.. A green lifetime biosensor for calcium that remains bright over its full dynamic range

Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches

Kavli Affiliate: Erich Jarvis | Authors: Matthew Davenport, Ha Na Choe, Hiroaki Matsunami and Erich D Jarvis | Summary: Zebra finches are sexually dimorphic vocal learners. Males learn to sing by imitating mature conspecifics, but females do not. Absence of song in females is associated with atrophy and apparent repression of several vocal learning brain […]


Continue.. Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches

ybx1 acts upstream of atoh1a to promote the rapid regeneration of hair cells in zebrafish lateral-line neuromasts

Kavli Affiliate: A. James Hudspeth | Authors: Caleb C. Reagor and A. J. Hudspeth | Summary: Like the sensory organs of the human inner ear, the lateral-line neuromasts (NMs) of fish such as the zebrafish (Danio rerio) contain mechanosensory hair cells (HCs) that are surrounded by progenitors called supporting cells. Damaged NMs can quickly regenerate […]


Continue.. ybx1 acts upstream of atoh1a to promote the rapid regeneration of hair cells in zebrafish lateral-line neuromasts

Gut bacteria-derived succinate induces enteric nervous system regeneration

Kavli Affiliate: Daniel Mucida | Authors: Begüm Aydin, Izabela Mamede, Joana Cardoso, Julia Deere, Yelina Alvarez, Shanshan Qiao, Ved P. Sharma, Marissa A. Scavuzzo, Gregory P. Donaldson, Chun-Jun Guo and Daniel Mucida | Summary: Enteric neurons control gut physiology by regulating peristalsis, nutrient absorption, and secretion. Disruptions in microbial communities caused by antibiotics or enteric […]


Continue.. Gut bacteria-derived succinate induces enteric nervous system regeneration

Complete sequencing of ape genomes

Kavli Affiliate: Erich Jarvis | Authors: DongAhn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A. Logsdon, Steven J. Solar, Dmitry Antipov, Brandon D. Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M. Storer, Jiadong Lin, Abigail N. Sequeira, Riley J. Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R. […]


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Quantifying transcriptome turnover on phylogenies by modeling gene expression as a binary trait

Kavli Affiliate: Li Zhao | Authors: Ammon Thompson, Michael R. May, Ben Hopkins, Nerisa Riedl, Olga Barmina, Benjamin J. Liebeskind, Li Zhao, David Begun and Artyom Kopp | Summary: Changes in gene expression are a key driver of phenotypic evolution, leading to a persistent interest in the evolution of transcriptomes. Traditionally, gene expression is modeled […]


Continue.. Quantifying transcriptome turnover on phylogenies by modeling gene expression as a binary trait

Long-Term Effects of Early Adolescent Second-Generation Antipsychotic Exposure on Body Weight, Caloric Intake, and Metabolism-Associated Gene Expression

Kavli Affiliate: Michael W. Young | Authors: Paul Soto, Michael E Young, Serena Nguyen, Megan Federoff, Mia M Goodson, Christopher D Morrison, Heidi Batdorf, Susan Burke and Jason Collier | Summary: The use of second-generation antipsychotic (SGA) medications in pediatric patients raises concerns about potential long-term adverse outcomes. The current study evaluated the long-term effects […]


Continue.. Long-Term Effects of Early Adolescent Second-Generation Antipsychotic Exposure on Body Weight, Caloric Intake, and Metabolism-Associated Gene Expression

Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine

Kavli Affiliate: Charles M. Rice | Authors: Samantha G Muccilli, Bejamin Schwarz, Forrest Jessop, Jeffrey G. Shannon, Eric Bohrnsen, Byron Shue, Seon-Hui Hong, Thomas Hsu, Alison W. Ashbrook, Joseph W. Guarnieri, Justin Lack, Douglas C. Wallace, Catharine M. Bosio, Margaret R. MacDonald, Charles M Rice, Jonathan W Yewdell and Sonja M. Best | Summary: The […]


Continue.. Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine

Spontaneously regenerative corticospinal neurons in mice

Kavli Affiliate: Nathaniel Heintz | Authors: Benjamin W Fait, Bianca Cotto, Tatsuya C Murakami, Michael Hagemann-Jensen, Huiqing Zhan, Corinne Freivald, Isadora Turbek, Yuan Gao, Zizhen Yao, Sharon W Way, Hongkui Zeng, Bosiljka Tasic, Oswald Steward, Nathaniel Heintz and Eric F Schmidt | Summary: The spinal cord receives inputs from the cortex via corticospinal neurons (CSNs). […]


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Differential splice isoforms of mouse CDK2 play functionally redundant roles during mitotic and meiotic division

Kavli Affiliate: Li Zhao | Authors: Nathan Palmer, S. Zakiah A. Talib, Jin Rong Ow, Tommaso Tabaglio, Christine M.F. Goh, Li Na Zhao, Ernesto Guccione, Kui Liu and Philipp Kaldis | Summary: In most mammals, the cell cycle kinase; cyclin-dependent kinase 2 (CDK2) is expressed as two major isoforms due to the inclusion or exclusion […]


Continue.. Differential splice isoforms of mouse CDK2 play functionally redundant roles during mitotic and meiotic division