Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilization

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Priya Rajasethupathy | Authors: Andrea Terceros, Celine Chen, Yujin Harada, Tim Eilers, Millennium Gebremedhin, Richard P Koche, Pierre-Jacques Hamard, Roshan Sharma and Priya Rajasethupathy | Summary: The molecular mechanisms that enable memories to persist over long time-scales from days to weeks and months are still poorly understood. To develop insights we created a […]


Continue.. Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilization

Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington’s disease

Posted by dbos Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Matthew Baffuto, Kert Mätlik, Isaac Ilyashov, Maria Esterlita Siantoputri, Hasnahana Chetia, Yurie Harada, Erika Sipos, Paul Darnell, Laura Kus, Thomas Carroll, Douglas Barrows, Christina Pressl, Nicholas Didkovsky and Nathaniel Heintz | Summary: Huntington’s disease (HD) is characterized by neuronal dysfunction and degeneration that varies markedly by brain region and […]


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An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Matthew A Cattle, Lauren C Aguado, Samantha Sze, Dylan Yueyang Wang, Thales Papagiannakopoulos, Susan Smith, Charles M Rice, William Matthew Schneider and John T Poirier | Summary: Retrons are a retroelement class found in diverse prokaryotes that can be adapted to augment CRISPR-Cas9 genome engineering technology to efficiently […]


Continue.. An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks

Short-term gonadal cultures are sufficient for germline transmission in a songbird

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Matthew T Biegler, Elijah Harter, Asha V Sidhu, Christina Szialta, Gillian Durham, Lotem Tchernichovski, Paul Collier, Ji-Dung Luo, Wei Wang, Ryan MacIsaac, Kirubel Belay, Thomas Carroll, Anna L Keyte and Erich D Jarvis | Summary: Primordial germ cells (PGCs) are germline stem cells that develop into sperm or egg […]


Continue.. Short-term gonadal cultures are sufficient for germline transmission in a songbird

ARAP2 regulates responses to interferon-gamma by restricting SOCS1

Posted by dbos Rockefeller

Kavli Affiliate: Jean-Laurent Casanova | Authors: Narelle Keating, Karen Doggett, Grace Bidgood, Lizeth G Meza Guzman, Laura Dagley, Kunlun Li, Anna Gabrielyan, Carolina Alvarado, Bailey Williams, Benjamin Broomfield, Brigette Duckworth, Colin Hockings, Jumana Youssef, Evelyn Leong, Rhiannon Morris, Andrew Kueh, Alexandra Garnham, Jean-Laurent Casanova, Stephanie Boisson-Dupuis, Jeffrey Babon, Edmond Linossi, Michelle D Tate, Joanna R. […]


Continue.. ARAP2 regulates responses to interferon-gamma by restricting SOCS1

Identification of a Thermogenic Target in the Dorsal Raphe Nucleus for Weight Management

Posted by dbos Rockefeller

Kavli Affiliate: Jeffrey M. Friedman and Nathaniel Heintz | Authors: Alexandre Moura-Assis, Kaja Plucinska, Aiste Baleisyte, David David, Kyle Pellegrino, Luca Parolari, Parolari T Shaked, Keith J Page, Douglas W Douglas, Thomas S Carrol, Jose G Grajales-Reyes, Daxiang Na, Hans H Schiffer, Yun Chen, Huikai Sun, Nidhi Cohen, Holger Monenschein, Daniel F Barker, Maria J […]


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Suite3D: Volumetric cell detection for two-photon microscopy

Posted by klaurent Rockefeller

Kavli Affiliate: Alipasha Vaziri | Authors: Ali Haydaroğlu, Sam Dodgson, Michael Krumin, Andrew Landau, Liad J. Baruchin, Tinya Chang, Jingkun Guo, David Meyer, Charu B. Reddy, Jian Zhong, Na Ji, Sylvia Schröder, Kenneth D. Harris, Alipasha Vaziri and Matteo Carandini | Summary: In two-photon imaging of neuronal activity it is common to acquire 3-dimensional volumes. […]


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Mosquito sex under lock and key

Posted by dbos Rockefeller

Kavli Affiliate: Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Madison M. Walker, Jacopo Razzauti, Anurag Sharma, H. Amalia Pasolli and Leslie B. Vosshall | Summary: Female mosquitoes typically mate once in a lifetime, making this singular mating decision critically important for the female. Yet, mosquito mating has been historically viewed as male-guided, with the female […]


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Seasonal brain regeneration and chromosome instability are linked to selection on DNA repair in Sorex araneus

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: William R Thomas, Tanya M Lama, Diana Moreno-Santillan, Marta Farre, Cecilia Baldoni, Linelle Abueg, Jennifer Balacco, Olivier Fedrigo, Giulio Formenti, Nivesh Jain, Jacquelyn Mountcastle, Tatiana Tilley, Alan Tracey, David A Ray, Dina K. N. Dechmann, Dominik von Elverfeldt, John Nieland, Angelique P Corthals, Erich Jarvis and Liliana M Davalos […]


Continue.. Seasonal brain regeneration and chromosome instability are linked to selection on DNA repair in Sorex araneus

Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich Tissues

Posted by dbos Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Tatsuya C. Murakami, Nick Belenko, Griffin Dennis, Cuidong Wang, Maria Esterlita Siantoputri, Yurie Maeda, Christina Pressl and Nathaniel Heintz | Summary: Fluorescent imaging enables visualization of the specific molecules of interest with high contrast, and the use of multiple fluorophores in a single tissue sample allows visualization of complex […]


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