Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Daniel Mucida | Authors: Shaina L Carroll, Andrew Ly, Ashley K Liu, Maria C.C. Canesso, Gabriel D Victora, Daniel Mucida and Gregory M Barton | Summary: How the complex network of intestinal antigen presenting cells (APCs) instructs CD4+ T cell […]


Continue.. Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation

Discovery Stack Pilot: Feasibility and Outcomes of a Scientist-Designed Peer Review Model Separating Quality and Impact

Kavli Affiliate: Daniel Mucida | Authors: Maureen A McGargill, Beiyun C Liu, Michael S Kuhns, Daniel Mucida, Isabella Rauch, Lauren B Rodda, Meghan A Koch, Hugo Gonzalez Velozo, Ken Cadwell, Tanya S Freedman, Tiffany C Scharschmidt, Richard Sever, Jose Ordovas-Montanes, Andrew Oberst, Brooke Runnette and Matthew F Krummel | Summary: In vitro modelling of highly […]


Continue.. Discovery Stack Pilot: Feasibility and Outcomes of a Scientist-Designed Peer Review Model Separating Quality and Impact

Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating

Kavli Affiliate: Roderick MacKinnon | Authors: George Vaisey and Roderick MacKinnon | Summary: Piezo1 ion channels are widely expressed cellular mechanosensors. They adopt an intrinsically curved shape when closed and are thought to open when mechanical forces applied to the membrane favor a more flattened conformation. By reconstituting Piezo1 channels into lipid vesicles, a flattened […]


Continue.. Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating

Exercise intensity modulates the human plasma secretome and interorgan communication

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Luke Olsen, Javier Botella, Douglas Barrows, Ethan Romero, Kaitlyn Baird, Mutsumi Katayama, Ece Kilic, Christopher Peralta, Henry Sanford, Laurie Farrell, Christopher L Axelrod, Kaja Plucinska, Jeanne Walker, Lu Yan, Katie Fredrickson, Olivier Pourquie, Jeremy M. Robbins, Ekaterina V Vinogradova, John P. Kirwan, Juleen R. Zierath, Anna Krook, Robert […]


Continue.. Exercise intensity modulates the human plasma secretome and interorgan communication

DNA methylation profiles in diabetic embryos

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Li Zhao | Authors: Pu-Yu Li, Fu-Li Zhao, Yi-Juan Song, Bing-Yao Lei, Hao-Jin Niu, Ying-Fang Wang and Hong-Wei Jiang | Summary: Maternal diabetes leads to neural tube defects (NTDs) in offspring. DNA methylation could be associated with NTDs induced by […]


Continue.. DNA methylation profiles in diabetic embryos

Non-canonical DNA in bird telomere-to-telomere genomes

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Erich Jarvis | Authors: Linnea Smeds, Simona Secomandi, Chul Lee, Francesca Chiaromonte, Erich Jarvis, Giulio Formenti and Kateryna Makova | Summary: Non-canonical (non-B) DNA motifs are genomic sequences capable of folding into three-dimensional structures distinct from the canonical right-handed helix. […]


Continue.. Non-canonical DNA in bird telomere-to-telomere genomes

C. elegans astrocytes mature in two phases from lineally distinct progenitors through CEH-43/DLX-mediated convergent transcription

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Shai Shaham | Authors: Simin Liu, Kenneth Bradley, Jinghong J. Tang, Yoon A. Kim, Ana Milosevic and Shai Shaham | Summary: Astrocytic glia regulate brain assembly, synapse formation/activity, neuronal energetics, and brain metabolism. Gene programs driving astrocyte specification are only […]


Continue.. C. elegans astrocytes mature in two phases from lineally distinct progenitors through CEH-43/DLX-mediated convergent transcription

CED-3 caspase promotes dismantling but not onset of non-apoptotic linker cell death in C. elegans

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Shai Shaham | Authors: Olya Yarychkivska, Lena M Kutscher, Dana Mamriev, Betty Ortiz Bido, Yun Lu, Wolfgang Keil, Sarit Larisch and Shai Shaham | Summary: Nuclear degradation accompanies cell death. To study this process, we followed nuclear dismantling of the […]


Continue.. CED-3 caspase promotes dismantling but not onset of non-apoptotic linker cell death in C. elegans

A reference brain for the clonal raider ant

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Daniel Kronauer | Authors: Dominic D. Frank, Lindsey E. Lopes, Rishika Mohanta, Isabelle Seckler, Ivan Lacroix and Daniel J.C. Kronauers | Summary: Ants exhibit remarkable collective and social behaviors, such as alloparental care1, chemical communication2, homing3, and cooperative group hygiene4. […]


Continue.. A reference brain for the clonal raider ant

The complete genome of a songbird

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Erich Jarvis | Authors: Giulio Formenti, Nivesh Jain, Jack A Medico, Marco Sollitto, Dmitry Antipov, Jennifer Balacco, Suziane Barcellos, Matthew T Biegler, Ines Borges, J King Chang, Ying Chen, Haoyu Cheng, Helena B Conceicao, Matthew Davenport, Lorraine C De Oliveira, […]


Continue.. The complete genome of a songbird