Neuroscience – Page 92 – Kavli Institute Pre-Print Publications

High-throughput colocalization pipeline quantifies efficacy of mitochondrial targeting signals across different protein types

Posted by klaurent April 3, 2023April 10, 2023UCSF

Kavli Affiliate: Seth Shipman | Authors: Sierra K Lear, Jose A Nunez and Seth L Shipman | Summary: Efficient metabolic engineering and the development of mitochondrial therapeutics often rely upon the specific and strong import of foreign proteins into mitochondria. Fusing a protein to a mitochondria-bound signal peptide is a common method to localize proteins […]

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Human Connectomes Are Heritable

Posted by klaurent April 3, 2023April 10, 2023Hopkins

Kavli Affiliate: Joshua Vogelstein | Authors: Jaewon Chung, Eric W Bridgeford, Michael Powell and Joshua T Vogelstein | Summary: The heritability of human connectomes is crucial for understanding the genetic and environmental factors that influence variations in connectomes, which can provide insights into behavior and disease. However, current approaches to studying connectome heritability assume an […]

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Studying of RNA-protein interactions between a mutant form of glycyl-tRNA synthetase associated with neurodegenerative diseases and IRES type I

Posted by klaurent March 30, 2023April 10, 2023Rockefeller

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Ekaterina Vinogradova, Alisa Mikhaylina, Oleg Nikonov and Ekaterina Nikonova | Summary: Aminoacyl-tRNA synthetases (aaRS) are the main enzymes of protein biosynthesis. Human glycyl-tRNA synthetase, in addition to the main function of amino acid transfer to the corresponding tRNA molecules, is also involved in the initiation of IRES I […]

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A Universal Method for Crossing Molecular and Atlas Modalities using Simplex-Based Image Varifolds and Quadratic Programming

Posted by klaurent March 29, 2023April 10, 2023Hopkins

Kavli Affiliate: Laurent Younes, Michael Miller, Jean Fan | Authors: Kaitlin M Stouffer, Alain Trouve, Laurent Younes, Michael Kunst, Lydia Ng, Hongkui Zeng, Manjari Anant, Jean Fan, Yongsoo Kim and Michael I Miller | Summary: This paper explicates a solution to the problem of building correspondences between molecular-scale transcriptomics and tissue-scale atlases. The central model […]

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SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

Posted by klaurent March 27, 2023April 10, 2023UCSD / Salk

Kavli Affiliate: Jose Ricardo Suarez | Authors: Blanca Dies, Ana de Lucas-Rius, Laura Mendoza, Transito Garcia, Raul Fernandez, Jose Manuel Suarez, Fatima Milhano, Fernando Corrales, Natalia Redondo, Federica Pedrucci, Sara Zaldivar, Maria Angeles Jimenez, Maria Montoya and Juan Jose Garrido | Summary: SARS-CoV-2, the cause of the COVID19 pandemic, possesses eleven accessory proteins encoded in […]

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Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons

Posted by klaurent March 26, 2023April 5, 2023Columbia

Kavli Affiliate: Franck Polleux | Authors: Daniel M Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Emiliano Zamponi, Natalie J Park, Victoria L Hewitt, David Zhang, Kevin C Gonzalez, Erik Bloss, Franck Polleux and Tommy L Lewis, Jr. | Summary: Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles […]

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SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling

Posted by klaurent March 26, 2023April 5, 2023UCSF

Kavli Affiliate: Yuh Nung Jan, Lily Jan | Authors: Sami Tapio Tuomivaara, Chin Fen Teo, Yuh Nung Jan, Lily Y Jan and Arun Paul Wiita | Summary: To facilitate our understanding of the often rapid and nuanced dynamics of extracellularly exposed proteomes during signaling events, it is important to devise robust workflows affording fast time […]

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Leveraging vision to understand curiosity

Posted by klaurent March 23, 2023March 27, 2023Columbia

Kavli Affiliate: Jacqueline Gottlieb | Authors: Michael Cohanpour, Mariam Aly and Jacqueline Gottlieb | Summary: Humans are immensely curious and motivated to reduce uncertainty. Inspired by studies of sensory uncertainty, we hypothesized that visual areas provide multivariate representations of uncertainty, which are read out by higher-order areas that encode confidence and, ultimately, translated into curiosity. […]

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A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements

Posted by klaurent March 21, 2023April 5, 2023UCSD / Salk

Kavli Affiliate: Samuel Pfaff | Authors: Marito Hayashi, Miriam Gullo, Gokhan Senturk, Stefania Di Costanzo, Shinji C. Nagasaki, Ryoichiro Kageyama, Itaru Imayoshi, Martyn Goulding, Samuel L. Pfaff and Graziana Gatto | Summary: Innate and goal-directed movements require a high-degree of trunk and appendicular muscle coordination to preserve body stability while ensuring the correct execution of […]

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Mesoscale volumetric light field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz

Posted by klaurent March 21, 2023April 5, 2023Rockefeller

Kavli Affiliate: Alipasha Vaziri | Authors: Tobias Nöbauer, Yuanlong Zhang, Hyewon Kim and Alipasha Vaziri | Summary: Various implementations of mesoscopes provide optical access for calcium imaging across multi-millimeter fields-of-view (FOV) in the mammalian brain. However, capturing the activity of the neuronal population within such FOVs near-simultaneously and in a volumetric fashion has remained challenging […]

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