Kavli Affiliate: Michael W. Young | Authors: Georgia F Papadaki, Claire H Woodward, Michael C Young, Trenton J Winters, George M Burslem and Nikolaos G Sgourakis | Summary: Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to the endoplasmic […]
Kavli Affiliate: Ali H. Brivanlou | Authors: Tiago L Laundos, Shu Li, Eric Cheang, Riccardo De Santis, Francesco M Piccolo and Ali H. Brivanlou | Summary: Huntington’s disease (HD) remains an incurable and fatal neurodegenerative disease long after CAG-expansion mutation in the huntingtin gene (HTT) was identified as the cause. The underlying pathological mechanism, whether […]
Kavli Affiliate: Philip Starr | Authors: Md Fahim Anjum, Clay Smyth, Derk-Jan Dijk, Philip Starr, Timothy Denison and Simon Little | Summary: Background: Sleep disturbance is a prevalent and highly disabling comorbidity in individuals with Parkinson’s disease (PD) that leads to worsening of daytime symptoms, accelerated disease progression and reduced quality of life. Objectives: We […]
Kavli Affiliate: David Linden | Authors: Daniel C de la Fuente, Claudia Tamburini, Emily Stonelake, William J Griffiths, Jeremy Hall, Michael J Owen, David E. J. Linden, Andrew Pocklington, Yuqin Wang and Meng Li | Summary: Dysregulation in neural progenitor proliferation and neuronal differentiation has been increasingly recognised as a common pathology in neural cells […]
Kavli Affiliate: Robert Hawkins | Authors: Kerriann K Badal, Abhishek Sadhu, Carrie McCracken, Bindu L Raveendra, Sebastian Lozano-Villada, Amol C Shetty, Phillip Gillette, Yibo Zhao, Dustin Stommes, Lynne A Fieber, Michael C Schmale, Anup Mahurkar, Robert D Hawkins and Sathyanarayanan V Puthanveettil | Summary: Molecular mechanisms underlying aging associated impairments in learning and long-term memory […]
Kavli Affiliate: Shai Shaham | Authors: Itai Rieger, Guy Weintraub, Itamar Lev, Kesem Goldstein, Dana Bar-Zvi, Sarit Anava, Hila Gingold, Shai Shaham and Oded Rechavi | Summary: Studies using C. elegans nematodes demonstrated that, against the dogma, animals can transmit epigenetic information transgenerationally. While it is now clear that in these worms ancestral RNA interference […]
Kavli Affiliate: Alex Kolodkin | Authors: Joelle M Dorskind, Sriram Sudarsanam, Randal A Hand, Jakub Ziak, Maame Amoah-Dankwah, Luis Guzman-Clavel, John Lee Soto-Vargas and Alex L Kolodkin | Summary: Proper cortical lamination is essential for cognition, learning, and memory. Within the somatosensory cortex, pyramidal excitatory neurons elaborate axon collateral branches in a laminar-specific manner that […]
Kavli Affiliate: Patrick Kanold | Authors: Loren Koçillari, Marco Celotto, Nikolas A. Francis, Shoutik Mukherjee, Behtash Babadi, Patrick O. Kanold and Stefano Panzeri | Summary: Measures of functional connectivity have played a central role in advancing our understanding of how information is communicated within the brain. Traditionally, these studies have focused on identifying redundant functional […]
Kavli Affiliate: Michael Stryker | Authors: Megumi Kaneko, Mahmood S Hoseini, James A Waschek and Michael P Stryker | Summary: When adult mice are repeatedly exposed to a particular visual stimulus for as little as one hour per day for several days while their visual cortex (V1) is in the high-gain state produced by locomotion, […]
Kavli Affiliate: Yifan Cheng | Authors: Un Seng Chio, Eugene Palovcak, Anton A. A. Autzen, Henriette E. Autzen, Elise N. Munoz, Zanlin Yu, Feng Wang, David A. Agard, Jean-Paul Armache, Geeta Narlikar and Yifan Cheng | Summary: Single-particle cryo-EM is widely used to determine enzyme-nucleosome complex structures. However, cryo-EM sample preparation remains challenging and inconsistent […]