Kavli Affiliate: Mary E. Hatten, C. David Allis | Authors: Kärt Mätlik, Eve-Ellen Govek, Matthew R. Paul, C. David Allis and Mary E. Hatten | Summary: Abstract Developing neurons undergo a progression of morphological and gene expression changes as they transition from neuronal progenitors to mature, multipolar neurons. Here we use RNA-seq and H3K4me3 and […]
Kavli Affiliate: Anders Dale | Authors: Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Anders Dale, Eivind Hovig and Ole Andreassen | Summary: Abstract Discoveries from genome-wide association studies often contain large clusters of highly correlated genetic variants, which makes them hard to interpret. In such cases, finemapping the underlying causal variants […]
Kavli Affiliate: Keri Martinowich | Authors: Chaichontat Sriworarat, Annie B. Nguyen, Nicholas J. Eagles, Leonardo Collado-Torres, Keri Martinowich, Kristen R. Maynard and Stephanie C. Hicks | Summary: High-resolution and multiplexed imaging techniques are giving us an increasingly detailed observation of a biological system. However, sharing, exploring, and customizing the visualization of large multidimensional images can […]
Kavli Affiliate: Denis Wirtz | Authors: Alicia M Braxton, Ashley L Kiemen, Mia P Grahn, Andre Forjaz, Jaanvi Mahesh Babu, Lily Zheng, Liping Jiang, Haixia Cheng, Qianqian Song, Rebecca Reichel, Sarah Graham, Alexander I Damanakis, Catherine G Fischer, Stephanie Mou, Cameron Metz, Julie Granger, Xiao-Ding Liu, Niklas Bachmann, Cristina Almagro-Perez, Ann Chenyu Jiang, Jeonghyun Yoo, […]
Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Keith Fritzsching, Rivkah Rogawski, Yunyao Xu and Ann E McDermott | Summary: While low temperature NMR holds great promise for the analysis of unstable samples and for sensitizing NMR detection, spectral broadening in frozen protein samples is a common experimental challenge. One hypothesis explaining the additional linewidth […]
Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Lichirui Zhang, Richard Friesner and Ann E McDermott | Summary: NMR chemical shifts provide a sensitive probe of protein structure and dynamics. Prediction of shifts, and therefore interpretation of shifts, particularly for the frequently measured amidic 15N sites, remains a tall challenge. We demonstrate that protein 15N […]
Kavli Affiliate: Ann McDermott | Authors: Yizhuo Yang, Keith Fritzsching, Sasha He and Ann E McDermott | Summary: T-Cell Intracellular Antigen-1 (TIA1) is a 43 kDa multi-domain RNA-binding protein involved in stress granule formation during eukaryotic stress response, and has been implicated in neurodegenerative diseases including Welander distal myopathy and amyotrophic lateral sclerosis. TIA1 contains […]
Kavli Affiliate: Kenneth Miller | Authors: Agostina Palmigiano, Francesco Fumarola, Daniel P. Mossing, Nataliya Kraynyukova, Hillel Adesnik and Kenneth Miller | Summary: The visual cortex receives non-sensory inputs containing behavioral and brain state information. Here we propose a parallel between optogenetic and behavioral modulations of activity and characterize their impact on cell-type-specific V1 processing under […]
Kavli Affiliate: Patrick Kanold | Authors: Dan Luo, Ji Liu, Ryszard Auksztulewicz, Tony Ka Wing Yip, Patrick O. Kanold and Jan W. Schnupp | Summary: Detecting patterns, and noticing unexpected pattern changes, in the environment is a vital aspect of sensory processing. Adaptation and prediction error responses are two components of neural processing related to […]
Kavli Affiliate: Saul Kato | Authors: Morgan M Stanton, Sara Modan, Patrick M Taylor, Harsh N Hariani, Jordan Sorokin, Brian G Rash, Sneha B Rao, Alejandro Lopez-Tobon, Luigi Enriquez, Brenda Dang, Dorah Owango, Shannon O’Neill, Carlos Castrillo, Justin Nicola, Kathy Ye, Robert M Blattner, Federico Gonzalez, Dexter Antonio, Pavan Ramkumar, Andy Lash, Douglas Flanzer, Sophia […]