Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders

Posted by dbos Rockefeller

Kavli Affiliate: Timothy A. Ryan | Authors: Mukesh Kumar, Justin Knapp, Kallol Gupta and Timothy A Ryan | Summary: Recent advances have expanded the role of lipid droplets (LDs) beyond passive lipid storage, implicating their involvement in various metabolic processes across mammalian tissues. Neuronal LDs, long debated in existence, have been identified in several neural […]


Continue.. Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders

Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson’s disease patients with PINK1 and PARK2 mutations

Posted by klaurent UCSD / Salk

Kavli Affiliate: Fred Gage | Authors: Utkarsh Tripathi, Idan Rosh, Ran Ben Ezer, Ritu Nayak, Ashwani Choudhary, Jose Djamus, Andreea Manole, Henry Houlden, Fred H. Gage and Shani Stern | Summary: Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Primary symptoms of PD arise with the loss of dopaminergic (DA) neurons in […]


Continue.. Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson’s disease patients with PINK1 and PARK2 mutations

Two types of locus coeruleus norepinephrine neurons drive reinforcement learning

Posted by klaurent Hopkins

Kavli Affiliate: Jeremiah Cohen | Authors: Zhixiao Su and Jeremiah Y. Cohen | Summary: Abstract The cerebral cortex generates flexible behavior by learning. Reinforcement learning is thought to be driven by error signals in midbrain dopamine neurons. However, they project more densely to basal ganglia than cortex, leaving open the possibility of another source of […]


Continue.. Two types of locus coeruleus norepinephrine neurons drive reinforcement learning

Visuomotor interactions in the mouse forebrain mediated by extrastriate cortico-cortical pathways

Posted by klaurent NTNU

Kavli Affiliate: Menno Witter, Jonathan Whitlock | Authors: Karoline Hovde, Ida V. Rautio, Andrea Marie Hegstad, Menno P. Witter and Jonathan R. Whitlock | Summary: Abstract The mammalian visual system can be broadly divided into two functional processing pathways: a dorsal stream supporting visually and spatially guided actions, and a ventral stream enabling object recognition. […]


Continue.. Visuomotor interactions in the mouse forebrain mediated by extrastriate cortico-cortical pathways

Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells

Posted by klaurent Columbia

Kavli Affiliate: Rene Hen | Authors: Sebnem N. Tuncdemir, Andres D. Grosmark, Hannah Chung, Victor M. Luna, Clay O. Lacefield, Attila Losonczy and Rene Hen | Summary: Abstract The hippocampal dentate gyrus (DG) exhibits a unique form of neural plasticity that results from continuous integration of adult born neurons, referred to as ‘adult neurogenesis’. Recent […]


Continue.. Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells

Engineered retrovirus-like Arc extracellular vesicles for the in vivo targeted delivery of mRNA into the brain

Posted by klaurent Columbia

Kavli Affiliate: Robert Hawkins | Authors: Wenchao Gu, Sijin Luozhong, Ketaki Londhe, Nadine Elkasri, Simian Cai, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Melissa Warden, Robert Langer and Shaoyi Jiang | Summary: Abstract Systemic […]


Continue.. Engineered retrovirus-like Arc extracellular vesicles for the in vivo targeted delivery of mRNA into the brain

Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs)

Posted by klaurent Rockefeller

Kavli Affiliate: Thomas P. Sakmar | Authors: Ilana B. Kotliar, Emilie Ceraudo, Kevin Kemelmakher-Liben, Deena A. Oren, Emily Lorenzen, Tea Dodig-Crnković, Mizuho Horioka-Duplix, Thomas Huber, Jochen M. Schwenk and Thomas P. Sakmar | Summary: Abstract Cholestatic itch is a severe and debilitating symptom in liver diseases with limited treatment options. The class A G protein-coupled […]


Continue.. Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs)

The alarm pheromone and alarm response of the clonal raider ant

Posted by klaurent Rockefeller

Kavli Affiliate: Daniel Kronauer | Authors: Lindsey E. Lopes, Erik T. Frank, Zsolt Kárpáti, Thomas Schmitt and Daniel J.C. Kronauer | Summary: Abstract Ants communicate via an arsenal of different pheromones produced in a variety of exocrine glands. For example, ants release alarm pheromones in response to danger to alert their nestmates and to trigger […]


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Microdissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice

Posted by klaurent NTNU

Kavli Affiliate: Menno Witter, Asgeir Kobro-Flatmoen | Authors: Katrine Sjaastad Hanssen, Menno P. Witter, Axel Sandvig, Ioanna Sandvig and Asgeir Kobro-Flatmoen | Summary: Abstract Background Primary neuronal cultures enable cell-biological studies of Alzheimer’s disease (AD), albeit typically non-neuron-specific. The first cortical neurons affected in AD reside in layer II of the lateralmost part of the […]


Continue.. Microdissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice

Structural basis for CaVα2δ:gabapentin binding

Posted by klaurent UCSF

Kavli Affiliate: Daniel Minor | Authors: Daniel L Minor, Jr., Zhou Chen and Abhisek Mondal | Summary: Abstract Gabapentinoid drugs for pain and anxiety act on the CaVα2δ-1 and CaVα2δ-2 subunits of high-voltage activated calcium channels (CaV1s and CaV2s). Here, we present the cryo-EM structure of the gabapentin-bound brain and cardiac CaV1.2/CaVβ3/CaVα2δ-1 channel. The data […]


Continue.. Structural basis for CaVα2δ:gabapentin binding