Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene

Kavli Affiliate: Keri Martinowich | Authors: Genevieve E Craig, Lizbeth Ramos, Samuel R Essig, Nicholas J Eagles, Andrew E Jaffe, Keri Martinowich and Henry L Hallock | Summary: Deficits in attention are common across a range of neuropsychiatric disorders. A multitude of brain regions, including the frontal cortex (FC) and locus coeruleus (LC), have been […]


Continue.. Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene

G-quadruplexes are a source of vulnerability in BRCA2 deficient granule cell progenitors and medulloblastoma

Kavli Affiliate: Mary E. Hatten | Authors: Danielle L. Keahi, Mathijs A. Sanders, Matthew R. Paul, Andrew L.H. Webster, Yin Fang, Tom F. Wiley, Samer Shalaby, Thomas S. Carroll, Settara C. Chandrasekharappa, Carolina Sandoval-Garcia, Margaret L. MacMillan, John E. Wagner, Mary E. Hatten and Agata Smogorzewska | Summary: Biallelic pathogenic variants in the essential DNA […]


Continue.. G-quadruplexes are a source of vulnerability in BRCA2 deficient granule cell progenitors and medulloblastoma

Decoding contextual influences on auditory perception from primary auditory cortex

Kavli Affiliate: Mounya Elhilali | Authors: Bernhard Englitz, Sahar Akram, Mounya Elhilali and Shihab Shamma | Summary: SPerception can be highly dependent on stimulus context, but whether and how sensory areas encode the context remains uncertain. We used an ambiguous auditory stimulus – a tritone pair – to investigate the neural activity associated with a […]


Continue.. Decoding contextual influences on auditory perception from primary auditory cortex

Mammalian D-Cysteine controls insulin secretion in the pancreas

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Timothy West, Soumyaroop Bhattacharya, Harry Saavedra, Lauren Albacarys, Moataz M Gadalla, Leon Mario Amzel, Peixin Yang and Solomon H. Snyder | Summary: D-amino acids are being recognized in mammals as important molecules with function. This is a first identification of endogenous D-cysteine in mammalian pancreas. D-cysteine is […]


Continue.. Mammalian D-Cysteine controls insulin secretion in the pancreas

A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus.

Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B Kennedy | Summary: Long-term potentiation (LTP) is a biochemical process in excitatory glutamatergic synapses in the Central Nervous System (CNS). It is initiated by a bout of synaptic activation that is strong enough to contribute to […]


Continue.. A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus.

The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice

Kavli Affiliate: Vikram Chib | Authors: Grace E Steward and Vikram S Chib | Summary: Feelings of cognitive fatigue emerge through repeated mental exertion and are ubiquitous in our daily lives. However, there is a limited understanding of the neurobiological mechanisms underlying the influence of cognitive fatigue on decisions to exert. We use functional magnetic […]


Continue.. The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice

Resistance to age-related hearing loss in the echolocating big brown bat (Eptesicus fuscus)

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Bryan Zhou, AndrĂ© Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin and Denis Wirtz | Summary: Enrichment of […]


Continue.. Resistance to age-related hearing loss in the echolocating big brown bat (Eptesicus fuscus)

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Bryan Zhou, AndrĂ© Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin and Denis Wirtz | Summary: Enrichment of […]


Continue.. High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

Sst- and Vip-Cre mouse lines without age-related hearing loss

Kavli Affiliate: Andrea Hasenstaub | Authors: Calvin T Foss, Timothy Olsen, James Bigelow and Andrea R Hasenstaub | Summary: GABAergic interneurons, including somatostatin (SST) and vasoactive intestinal peptide (VIP) positive cells, play a crucial role in cortical circuit processing. Cre recombinase-mediated manipulation of these interneurons is facilitated by commercially available knock-in mouse strains such as […]


Continue.. Sst- and Vip-Cre mouse lines without age-related hearing loss

Complementary Organization of Driver and Modulator Cortico-Thalamo-Cortical Circuits

Kavli Affiliate: Edward Callaway | Authors: Rachel M. Cassidy, Angel V. Macias, Willian N. Lagos, Chiamaka Ugorji and Edward M. Callaway | Summary: Corticocortical (CC) projections in the visual system facilitate the hierarchical processing of sensory information. In addition to direct CC connections, indirect cortico-thalamo-cortical (CTC) pathways through the pulvinar nucleus of the thalamus can […]


Continue.. Complementary Organization of Driver and Modulator Cortico-Thalamo-Cortical Circuits