Scalable electron tomography for connectomics

Kavli Affiliate: Mark Ellisman; | Authors: Aaron T Kuan, Sebastien Phan, Keun-Young Kim, Mason Mackey, Minsu Kim, Steven T Peltier, Mark Ellisman and Wei-Chung Allen Lee | Summary: We demonstrate limited-tilt, serial section electron tomography (ET), which can non-destructively map brain circuits over large 3D volumes and reveal high-resolution, supramolecular details within subvolumes of interest. […]


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Probabilistic graph-based model uncovers previously unseen druggable vulnerabilities in major solid cancers

Kavli Affiliate: Franck Polleux; | Authors: Koki Nakamura, Saeko Aoyama-Ishiwatari, Takahiro Nagao, Mohammadreza Paaran, Christopher J. Obara, Yui Sakurai-Saito, Jake Johnston, Yudan Du, Shogo Suga, Masafumi Tsuboi, Makoto Nakakido, Kouhei Tsumoto, Yusuke Kishi, Yukiko Gotoh, Chulhwan Kwak, Hyun-Woo Rhee, Jeong Kon Seo, Hidetaka Kosako, Clint Potter, Bridget Carragher, Jennifer Lippincott-Schwartz, Franck Polleux and Yusuke Hirabayashi […]


Continue.. Probabilistic graph-based model uncovers previously unseen druggable vulnerabilities in major solid cancers

PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

Kavli Affiliate: Franck Polleux; | Authors: Koki Nakamura, Saeko Aoyama-Ishiwatari, Takahiro Nagao, Mohammadreza Paaran, Christopher J. Obara, Yui Sakurai-Saito, Jake Johnston, Yudan Du, Shogo Suga, Masafumi Tsuboi, Makoto Nakakido, Kouhei Tsumoto, Yusuke Kishi, Yukiko Gotoh, Chulhwan Kwak, Hyun-Woo Rhee, Jeong Kon Seo, Hidetaka Kosako, Clint Potter, Bridget Carragher, Jennifer Lippincott-Schwartz, Franck Polleux and Yusuke Hirabayashi […]


Continue.. PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli; | Authors: Lorena Benedetti, Ruolin Fan, Aubrey V. Weigel, Andrew S. Moore, Patrick R. Houlihan, Mark Kittisopikul, Grace Park, Alyson Petruncio, Philip M. Hubbard, Song Pang, C. Shan Xu, Harald F. Hess, Stephan Saalfeld, Vidhya Rangaraju, David E. Clapham, Pietro De Camilli, Timothy A. Ryan and […]


Continue.. Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease

Kavli Affiliate: Stephan Anagnostaras; | Authors: Joseph Offenberger, Bianca Chen, Leigh-Ana Rossitto, Irisa Jin, Liam Conaboy, Helios Gallego-Gutierrez, Bliss Nelsen, Eduardo Frias-Anaya, David J. Gonzalez, Stephan Anagnostaras and Miguel Alejandro Lopez-Ramirez | Summary: Background Cerebral Cavernous Malformations (CCMs) are neurovascular abnormalities in the central nervous system (CNS) caused by loss of function mutations in KRIT1 […]


Continue.. Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease

Temporal-Coherence Induces Binding in Responses to Sound Sequences in Ferret Auditory Cortex

Kavli Affiliate: Mounya Elhilali/p> | Authors: Kai Lu, Kelsey Dutta, Ali Mohammed, Mounya Elhilali and Shihab Shamma | Summary: Binding the attributes of a sensory source is necessary to perceive it as a unified entity, one that can be attended to and extracted from its surrounding scene. In auditory perception, this is the essence of […]


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Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility

Kavli Affiliate: Jeremy Willsey/p> | Authors: Kate E McCluskey, Katherine M Stovell, Karen Law, Elina Kostyanovskaya, James Schmidt, Cameron RT Exner, Jeanselle Dea, Elise Brimble, Matthew W State, A Jeremy Willsey and Helen Rankin Willsey | Summary: The comorbidity of autism spectrum disorders and severe gastrointestinal symptoms is well-established, yet the molecular underpinnings remain unknown. […]


Continue.. Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility

Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids

Kavli Affiliate: Flora Vaccarino | Authors: Soraya Scuderi, Tae-Yun Kang, Alexandre Jourdon, Liang Yang, Feinan Wu, Alex Nelson, George M. Anderson, Jessica Mariani, VIVEKANANDA SARANGI, Alexej Abyzov, Andre Levchenko and Flora M. Vaccarino | Summary: The repertory of neurons generated by progenitor cells depends on their location along antero-posterior and dorso-ventral axes of the neural […]


Continue.. Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids

Differential Control of Inhibitory and Excitatory Nerve Terminal Function by Mitochondria

Kavli Affiliate: Timothy A. Ryan | Authors: Kirsten Bredvik and Timothy A Ryan | Summary: Inhibitory neurons shape the brain’s computational landscape and rely on different cellular architectures and intrinsic properties than excitatory neurons. Maintenance of the overall balance of excitatory (E) versus inhibitory (I) drive is essential, as disruptions can lead to neuropathological conditions, […]


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Dendritic excitations govern back-propagation via a spike-rate accelerometer

Kavli Affiliate: Liam Paninski | Authors: Pojeong Park, J. David Wong-Campos, Daniel Itkis, Byung Hun Lee, Yitong Qi, Hunter C. Davis, Benjamin Antin, Amol Praveen Pasarkar, Jonathan B. Grimm, Sarah E. Plutkis, Katie L. Holland, Liam Paninski, Luke Lavis and Adam Ezra Cohen | Summary: Dendrites on neurons support nonlinear electrical excitations, but the computational […]


Continue.. Dendritic excitations govern back-propagation via a spike-rate accelerometer