Neuroscience – Page 29 – Kavli Institute Pre-Print Publications

Comparative Single Cell Analysis of Transcriptional Bursting Reveals the Role of Genome Organization on de novo Transcript Origination

Posted by dbos April 29, 2024May 13, 2024Rockefeller

Kavli Affiliate: Li Zhao | Authors: UnJin Lee, Cong Li, Christopher B Langer, Nicolas Svetec and Li Zhao | Summary: Spermatogenesis is a key developmental process underlying the origination of newly evolved genes. However, rapid cell type-specific transcriptomic divergence of the Drosophila germline has posed a significant technical barrier for comparative single-cell RNA-sequencing (scRNA-Seq) studies. […]

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A recurrent network model of planning explains hippocampal replay and human behavior

Posted by klaurent April 28, 2024May 6, 2024UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Kristopher T. Jensen, Guillaume Hennequin and Marcelo G. Mattar | Summary: When interacting with complex environments, humans can rapidly adapt their behavior to changes in task or context. To facilitate this adaptation, we often spend substantial periods of time contemplating possible futures before acting. For such planning to be […]

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An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

Posted by dbos April 28, 2024May 6, 2024Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Erik D. Nelson, Madhavi Tippani, Anthony D. Ramnauth, Heena R. Divecha, Ryan A. Miller, Nicholas J. Eagles, Elizabeth A. Pattie, Sang Ho Kwon, Svitlana V. Bach, Uma M. Kaipa, Jianing Yao, Joel E. Kleinman, Leonardo Collado-Torres, Shizhong Han, Kristen R. Maynard, Thomas M. Hyde, Keri Martinowich, Stephanie C. Page […]

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Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor Microenvironments

Posted by dbos April 27, 2024May 6, 2024UCSF

Kavli Affiliate: Robert Edwards | Authors: Linzi Hosohama, Delia F. Tifrea, Kevin Nee, Sung Yun Park, Jie Wu, Amber N. Habowski, Cassandra Van, Marcus M. Seldin, Robert A. Edwards and Marian L. Waterman | Summary: Several classification systems have been developed to define tumor subtypes in colorectal cancer (CRC). One system proposes that tumor heterogeneity […]

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PACS-1 variant protein is aberrantly localized in C. elegans model of PACS1/PACS2 syndromes

Posted by dbos April 26, 2024May 6, 2024UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Dana T Byrd, Ziyuan Christina Han, Christopher A Piggott and Yishi Jin | Summary: PACS (Phosphofurin Acidic Cluster Sorting Protein) proteins are known for their roles in sorting cargo proteins to organelles and can physically interact with WD40 repeat-containing protein WDR37. PACS1, PACS2, and WDR37 variants are associated with […]

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Sampling Techniques and Genomic Analysis of Biological Material from Artworks

Posted by dbos April 26, 2024May 6, 2024Rockefeller

Kavli Affiliate: Thomas P. Sakmar | Authors: Rhonda K Roby, Rosana A Wiscovitch-Russo, Rebecca Hart, Amanda E Appel, Manija A Kazmi, Thomas Huber, Karina C Åberg, Thomas P Sakmar, José A Lorente and Norberto Gonzalez-Juarbe | Summary: The genomic analysis of biological material obtained from artwork or cultural heritage artifacts can be used to guide […]

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Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns from Breast Multiplexed Digital Pathology

Posted by dbos April 26, 2024May 6, 2024Hopkins

Kavli Affiliate: Jeremias Sulam | Authors: Zhenzhen Wang, Cesar A. Santa-Maria, Aleksander S. Popel and Jeremias Sulam | Summary: The tumor microenvironment is widely recognized for its central role in driving cancer progression and influencing prognostic outcomes. Despite extensive research efforts dedicated to characterizing this complex and heterogeneous environment, considerable challenges persist. In this study, […]

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Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species

Posted by dbos April 26, 2024May 6, 2024Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Robert A Phillips III, Seyun Oh, Svitlana V Bach, Yufeng Du, Ryan A Miller, Joel E Kleinman, Thomas M Hyde, Stephanie C Hicks, Stephanie Cerceo Page and Keri Martinowich | Summary: The lateral septum (LS) is a midline, subcortical structure, which regulates social behaviors that are frequently impaired in […]

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Widespread Receptive Field Remapping in Early Visual Cortex

Posted by klaurent April 25, 2024May 6, 2024Yale

Kavli Affiliate: Anirvan Nandy | Authors: Sachira Denagamage, Mitchell P Morton and Anirvan Nandy | Summary: Our eyes are in constant motion, yet we perceive the visual world as being stable. Predictive remapping of receptive fields is thought to be one of the critical mechanisms for enforcing perceptual stability during eye movements. While receptive field […]

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Magnetogenetic cell activation using endogenous ferritin

Posted by klaurent April 25, 2024May 6, 2024Rockefeller

Kavli Affiliate: Jeffrey M. Friedman | Authors: Lisa E Pomeranz, Rosemary Li, Xiaofei A Yu, Leah Kelly, Gholamreza Hassanzadeh, Henrik Molina, Daniel Gross, Matthew I Brier, George Vaisey, Putianqi Wang, Maria Jimenez-Gonzalez, Adolfo Garcia-Ocana, Jonathan Dordick, Jeffrey M. Friedman and Sarah A Stanley | Summary: The ability to precisely control the activity of defined cell […]

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