Neuroscience – Page 29 – Kavli Institute Pre-Print Publications

The ventral CA2 region of the hippocampus and its differential contributions to social memory and social aggression

Posted by dbos June 8, 2024June 17, 2024Columbia

Kavli Affiliate: Steven Siegelbaum; | Authors: Lara M. Boyle, Wanhui Sheng, Felix Leroy, Rhea Sahai, Sarah Irfan, Heon-Jin Lee, Andres Villegas, W. Scott Young and Steven A Siegelbaum | Summary: Although it is well-known that the hippocampus mediates declarative memory (the repository of information of people, places, things and events) and influences behavior, the differential […]

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RESPAN: an accurate, unbiased and automated pipeline for analysis of dendritic morphology and dendritic spine mapping

Posted by dbos June 8, 2024June 17, 2024Columbia

Kavli Affiliate: Franck Polleux; | Authors: Sergio B. Garcia, Alexa P. Schlotter, Daniela Pereira, Franck Polleux and Luke Hammond | Summary: Accurate and unbiased reconstructions of neuronal morphology, including quantification of dendritic spine morphology and distribution, are widely used in neuroscience but remain a major roadblock for large-scale analysis. Traditionally, spine analysis has required labor-intensive […]

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Disruption of Core Stress Granule Protein Aggregates Promotes CNS Axon Regeneration

Posted by dbos June 8, 2024June 17, 2024UCSD / Salk

Kavli Affiliate: Mark H. Tuszynski; | Authors: Pabitra K Sahoo, Nick Hanovice, Patricia Ward, Manasi A Agrawal, Terika P Smith, HaoMin SiMa, Jennifer N Dulin, Lauren S Vaughn, Mark Tuszynski, Kristy Welshhans, Larry Benowitz, Arthur English, John D Houle and Jeffery L Twiss | Summary: Depletion or inhibition of core stress granule proteins, G3BP1 in […]

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Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

Posted by dbos June 7, 2024June 17, 2024Rockefeller

Kavli Affiliate: Li Zhao; | Authors: Mingxin Xu, Neelima Thottappillil, Masnsen Cherief, Zhao Li, Manyu Zhu, Xin Xing, Mario Gomez-Salazar, Juliet Mukiri Mwirigi, Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Chi Zhang, Xue-Wei Wang, Mary Archer, Yun Guan, Robert J. Tower, Patrick Cahan, Theodore J. Price, Thomas L. Clemens and Aaron W. James | Summary: The profound pain […]

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Role of microglia in stress-induced alcohol intake in female and male mice

Posted by dbos June 6, 2024June 17, 2024Yale

Kavli Affiliate: Marina Picciotto; | Authors: Alexa Soares, Vernon Garcia-Rivas, Caroline Fai, Merrilee Thomas, Xiaoying Zheng, Marina Picciotto and Yann Mineur | Summary: Rates of alcohol use disorder (AUD) have escalated in recent years, with a particular increase among women. Women are more susceptible to stress-induced alcohol drinking, and preclinical data suggest that stress can […]

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Scalable electron tomography for connectomics

Posted by dbos June 6, 2024June 17, 2024UCSD / Salk

Kavli Affiliate: Mark Ellisman; | Authors: Aaron T Kuan, Sebastien Phan, Keun-Young Kim, Mason Mackey, Minsu Kim, Steven T Peltier, Mark Ellisman and Wei-Chung Allen Lee | Summary: We demonstrate limited-tilt, serial section electron tomography (ET), which can non-destructively map brain circuits over large 3D volumes and reveal high-resolution, supramolecular details within subvolumes of interest. […]

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Probabilistic graph-based model uncovers previously unseen druggable vulnerabilities in major solid cancers

Posted by dbos June 6, 2024June 17, 2024Rockefeller

Kavli Affiliate: Franck Polleux; | Authors: Koki Nakamura, Saeko Aoyama-Ishiwatari, Takahiro Nagao, Mohammadreza Paaran, Christopher J. Obara, Yui Sakurai-Saito, Jake Johnston, Yudan Du, Shogo Suga, Masafumi Tsuboi, Makoto Nakakido, Kouhei Tsumoto, Yusuke Kishi, Yukiko Gotoh, Chulhwan Kwak, Hyun-Woo Rhee, Jeong Kon Seo, Hidetaka Kosako, Clint Potter, Bridget Carragher, Jennifer Lippincott-Schwartz, Franck Polleux and Yusuke Hirabayashi […]

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PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

Posted by dbos June 3, 2024June 17, 2024Columbia

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Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Posted by dbos May 31, 2024June 17, 2024Rockefeller, Yale

Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli; | Authors: Lorena Benedetti, Ruolin Fan, Aubrey V. Weigel, Andrew S. Moore, Patrick R. Houlihan, Mark Kittisopikul, Grace Park, Alyson Petruncio, Philip M. Hubbard, Song Pang, C. Shan Xu, Harald F. Hess, Stephan Saalfeld, Vidhya Rangaraju, David E. Clapham, Pietro De Camilli, Timothy A. Ryan and […]

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Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease

Posted by dbos May 30, 2024June 17, 2024UCSD / Salk

Kavli Affiliate: Stephan Anagnostaras; | Authors: Joseph Offenberger, Bianca Chen, Leigh-Ana Rossitto, Irisa Jin, Liam Conaboy, Helios Gallego-Gutierrez, Bliss Nelsen, Eduardo Frias-Anaya, David J. Gonzalez, Stephan Anagnostaras and Miguel Alejandro Lopez-Ramirez | Summary: Background Cerebral Cavernous Malformations (CCMs) are neurovascular abnormalities in the central nervous system (CNS) caused by loss of function mutations in KRIT1 […]

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