Kavli Affiliate: Ali Brivanlou, Eric Siggia | Authors: Anna Yoney, Lu Bai, Ali H. Brivanlou and Eric D Siggia | Summary: Embryogenesis is guided by a limited set of signaling pathways dynamically expressed in different places. How a context dependent signaling response is generated has been a central question of developmental biology, which can now […]
Kavli Affiliate: Brian Caffo | Authors: Qi Huang, Bohao Tang, July Carolina Romero, Yuqian Yang, Saifeldeen Khalil Elsayed, Gayatri Pahapale, Tien-Jung Lee, Itzy Erin Morales Pantoja, Fang Han, Cynthia Berlinicke, Terry Xiang, Mallory Solazzo, Thomas Hartung, Zhao Qin, Brian Caffo, Lena Smirnova and David H Gracias | Summary: Brain organoids are important models for mimicking […]
Kavli Affiliate: Michael Keiser | Authors: Daniel R. Wong, Ziqi Tang, Nicholas C. Mew, Sakshi Das, Justin Athey, Kirsty E. McAleese, Julia K. Kofler, Margaret E. Flanagan, Ewa Borys, Charles L. White III, Atul J Butte, Brittany N Dugger and Michael J. Keiser | Summary: Pathologists can label pathologies differently, making it challenging to yield […]
Kavli Affiliate: Daeyeol Lee | Authors: Maxwell Shinn, Amber Hu, Laurel Turner, Stephanie Noble, Katrin H Preller, Jie Lisa Ji, Flora Moujaes, Sophie Achard, Dustin Scheinost, R Todd Constable, John Krystal, Franz X Vollenweider, Daeyeol Lee, Alan Anticevic, Edward T Bullmore and John D Murray | Summary: High-throughput experimental methods in neuroscience have led to […]
Kavli Affiliate: Seth Blackshaw | Authors: Nguyet Le, Haley Appel, Nicole Pannullo, Thanh Hoang and Seth Blackshaw | Summary: Direct reprogramming of retinal Müller glia is a promising avenue for replacing photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions have recently been raised about the accuracy of studies claiming efficient glia-to-neuron reprogramming […]
Kavli Affiliate: Robert Edwards | Authors: Victoria Stalls, Jared Lindenberger, Sophie Gobeil, Rory Henderson, Rob Parks, Maggie Barr, Margaret Deyton, Mitchell Martin, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, Esther Beaudoin, Robert J Edwards, Amanda Eaton, David Montefiori, Wilton Williams, Kevin O’Neil Saunders, Kevin Wiehe, Barton F Haynes and Priyamvada Acharya | Summary: The […]
Kavli Affiliate: John Reynolds | Authors: Naici Guo, Giorgos Minas, Silvia A Synowsky, Margaret R Dunne, Hasnain Ahmed, Rhiannon McShane, Anshul Bhardwaj, Noel E Donlon, Cliona Lorton, Jacintha O’Sullivan, John V Reynolds, Peter D Caie, Sally L Shirran, Andy G Lynch, Alan Stewart and Swati Arya | Summary: Oesophageal adenocarcinoma (OAC) is an aggressive cancer […]
Kavli Affiliate: Marvin Chun | Authors: Omid Kardan, Andrew J Stier, Carlos Cardenas-Inigues, Julia C Pruin, Kathryn E Schertz, Yuting Deng, Taylor Chamberlain, Wesley J Meredith, Xihan Zhang, Jilian E Bowman, Tanvi Lakhtakia, Lucy Tindel, Emily W Avery, Qi Lin, Kwangsun Yoo, Marvin M Chun, Marc G Berman and Monica D Rosenberg | Summary: Sustained […]
Kavli Affiliate: Joerg Bewersdorf, Pietro DeCamilli | Authors: Ons M’Saad, Ravikiran Kasula, Ilona Kondratiuk, Phylicia Kidd, Hanieh Falahati, Juliana E Gentile, Robert F Niescier, Katherine Watters, Robert C Sterner, Seong Lee, Xinran Liu, Pietro De Camilli, James E Rothman, Anthony J Koleske, Thomas Biederer and Joerg Bewersdorf | Summary: Understanding the molecular anatomy and neural […]
Kavli Affiliate: Li Zhao | Authors: Eric B Zheng and Li Zhao | Summary: De novo gene origination, where a previously non-genic genomic sequence becomes genic through evolution, has been increasingly recognized as an important source of evolutionary novelty across diverse taxa. Many de novo genes have been proposed to be protein-coding, and in several […]