Kavli Affiliate: Peter Walter | Authors: Advait Subramanian, Lan Wang, Tom Moss, Mark Voorhies, Smriti Sangwan, Erica Stevenson, Ernst H Pulido, Samentha Kwok, Nevan J Krogan, Danielle L Swaney, Stephen N Floor, Anita Sil, Peter Walter and Shaeri Mukherjee | Summary: Pathogens often secrete proteins or nucleic acids that mimic the structure and/or function of […]
Kavli Affiliate: Costa, Rui | Authors: Claire L Warriner, Samaher Fageiry, Shreya Saxena, Rui M Costa and Andrew Miri | Summary: During limb movement, spinal circuits facilitate the alternating activation of antagonistic flexor and extensor muscles. Yet antagonist cocontraction is often required to stabilize joints, like when loads are handled. Previous results suggest that these […]
Kavli Affiliate: Daniel Minor | Authors: Zhou Chen, Sandra Zakrzewska, Holly S. Hajare, Aurora Alvarez-Buylla, Fayal Abderemane-Ali, Maximiliana Bogan, Dave Ramirez, Lauren A. O’Connell, J. Du Bois and Daniel L. Minor, Jr. | Summary: American bullfrog (Rana castesbeiana) saxiphilin (RcSxph) is a high-affinity ‘toxin sponge’ protein thought to prevent intoxication by saxitoxin (STX), a lethal […]
Kavli Affiliate: V. S. Ramachandran | Authors: Vignesh Ramachandran, Gregory Hatlestad and Travis White | Summary: Background: One way single-celled eukaryotes respond to DNA damage stress is by modifying their gene expression, facilitating genomic repair. Gene expression responses to DNA damage induced by methyl methanesulfonate (MMS) have been studied in the model organism Saccharomyces cerevisiae. […]
Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Hasti Atashi and Solomon Snyder | Summary: The hippocampal CA3 subregion is a densely connected recurrent circuit that supports memory consolidation and retrieval by generating and storing sequential neuronal activity patterns that reflect recent experience. The encoding of precise temporal firing patterns in CA3 ensembles during awake-behavior […]
Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Hasti Atashi and Solomon Snyder | Summary: The adult subventricular zone is one of the two neurogenic niches that continuously produce newborn neurons. Here we show that serine racemase (SR), an enzyme that catalyzes the racemization of L-serine to D-serine and vice versa, affects neurogenesis in the […]
Kavli Affiliate: John Reynolds | Authors: Courtney Glavis-Bloom, Casey R Vanderlip and John H Reynolds | Summary: Aging is the greatest risk factor for the development of neurodegenerative diseases, yet we still do not understand how the aging process leads to pathological vulnerability. The research community has relied heavily on mouse models, but the considerable […]
Kavli Affiliate: Robert Hawkins | Authors: Sreejan Kumar, Theodore R. Sumers, Takateru Yamakoshi, Ariel Goldstein, Uri Hasson, Kenneth A. Norman, Thomas L. Griffiths, Robert D. Hawkins and Samuel A. Nastase | Summary: Piecing together the meaning of a narrative requires understanding not only the individual words but also the intricate relationships between them. How does […]
Kavli Affiliate: Jose Suarez Lopez | Authors: Ines Marin, Olga Boix, Andrea Garcia-Garijo, isabelle Sirois, Adria Caballe, Eduardo Zarzuela, Irene Ruano, Camille Stephan-Otto Attolini, Neus Prats, Jose Alberto Lopez-Dominguez, Marta Kovatcheva, Elena Garralda, Javier Munoz, Etienne Caron, Maria Abad, Alena Gros, Federico Pietrocola and Manuel Serrano | Summary: Cellular senescence is a stress response that […]
Kavli Affiliate: Jean Pierre Changeux | Authors: Sophie Shi, Solene N Lefebvre, Laurie Peverini, Adrien H Cerdan, Marc Gielen, Jean-Pierre Changeux, Marco CECCHINI and Pierre-Jean Corringer | Summary: Pentameric ligand-gated ion channel mediate signal transduction at chemical synapses by transiting between resting and open states upon neurotransmitter binding. Here, we investigate the gating transition of […]