Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis

Posted by klaurent UCSD / Salk

Kavli Affiliate: Dwight Bergles | Authors: Yiming Chao, Yang Xiang, Jiashun Xiao, Shihui Zhang, Weizhong Zheng, Xiaomeng Wan, Zhuoxuan LI, Mingze Gao, Gefei Wang, Zhilin Chen, Mo Ebrahimkhani, Can Yang, Angela Ruohao Wu, Pentao Liu, Yuanhua Huang and Ryohichi Sugimura | Summary: Abstract Single-cell level characterization of embryonic development is a major benchmark of human […]


Continue.. Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis

A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Marysia Placzek, Kavitha Chinnaiya, Sarah Burbridge, Aragorn Jones, Dong Won Kim, Elsie Place, Elizabeth Manning, Ian Groves, Changyu Sun, Matthew Towers and Seth Blackshaw | Summary: Abstract The tuberal hypothalamus houses several major hypothalamic nuclei, dozens of transcriptionally distinct cell types, and clinically relevant cell populations implicated in obesity […]


Continue.. A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

Regional and LTP-Dependent Variation of Synaptic Information Storage Capacity in Rat Hippocampus

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Mohammad Samavat, Thomas M Bartol, Cailey Bromer, Jared B Bowden, Dusten D Hubbard, Dakota C Hanka, Masaaki Kuwajima, John M Mendenhall, Patrick H Parker, Wickliffe C Abraham, Kristen M Harris and Terrence J Sejnowski | Summary: Abstract Synapses from the same axon onto the same dendrite have a common […]


Continue.. Regional and LTP-Dependent Variation of Synaptic Information Storage Capacity in Rat Hippocampus

Membrane remodeling properties of the Parkinson’s disease protein LRRK2

Posted by klaurent Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Xinbo Wang, Javier Espadas, Yumei Wu, Shujun Cai, Jinghua Ge, Lin Shao, Aurélien Roux and Pietro De Camilli | Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) are responsible for late-onset autosomal dominant Parkinson’s disease (PD). LRRK2 has been implicated in a wide range of physiological processes including membrane […]


Continue.. Membrane remodeling properties of the Parkinson’s disease protein LRRK2

Norepinephrine enhances oligodendrocyte precursor cell calcium dynamics in the cerebral cortex during arousal

Posted by klaurent Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Tsai-Yi Lu, Priyanka Hanumaihgari, Eric T Hsu, Amit Agarwal and Dwight E Bergles | Summary: Abstract Oligodendrocytes are generated from a widely distributed population of progenitors that express neurotransmitter receptors, but the mechanisms that alter activity of these oligodendrocyte precursor cells (OPCs) in vivo have not been determined. We […]


Continue.. Norepinephrine enhances oligodendrocyte precursor cell calcium dynamics in the cerebral cortex during arousal

Single cell transcriptomic profiling of human brain organoids reveals developmental timing- and cell-type-specific vulnerabilities induced by NRXN1 CNVs in schizophrenia

Posted by klaurent Hopkins

Kavli Affiliate: Jin Kang | Authors: ChangHui Pak, Rebecca Sebastian, Kang Jin, Narciso Pavon, Ruby Bansal, Andrew Potter, Yoonjae Song, Juliana Babu, Rafael Gabriel, Yubing Sun and Bruce J Aronow | Summary: Abstract De novo mutations and copy number variations (CNVs) in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). How NRXN1 CNVs impact […]


Continue.. Single cell transcriptomic profiling of human brain organoids reveals developmental timing- and cell-type-specific vulnerabilities induced by NRXN1 CNVs in schizophrenia

MicroRNA-218 instructs proper assembly of hippocampal networks

Posted by klaurent Rockefeller

Kavli Affiliate: Robert B. Darnell | Authors: Seth Taylor, Mariko Kobayashi, Antonietta Vilella, Durgesh Tiwari, Norjin Zolboot, Andrea Hartzell, Carol Girgiss, Yusuf Abaci, Claudia De Sanctis, Gian Carlo Bellenchi, Robert B Darnell, Christina Gross, Michele Zoli, Darwin K Berg and Giordano Lippi | Summary: ABSTRACT The assembly of the mammalian brain is orchestrated by temporally […]


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Human anti-ACE2 monoclonal antibodies as pan-sarbecovirus prophylactic agents

Posted by klaurent Rockefeller

Kavli Affiliate: Charles Rice | Authors: Fengwen Zhang, Jesse Jenkins, Renan V.H. de Carvalho, Sandra Nakandakari-Higa, Teresia Chen, Morgan E Abernathy, Elisabeth Nyakatura, David Andrew, Irina V. Lebedeva, Ivo C Lorenz, H.-Heinrich Hoffmann, Charles M. Rice, Gabriel D. Victora, Christopher O. Barnes, Theodora Hatziioannou and Paul D Bieniasz | Summary: Abstract Human monoclonal antibodies from […]


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Age-dependent changes in the dynamic functional organization of the brain at rest – a cross – cultural replication approach

Posted by klaurent Hopkins

Kavli Affiliate: David Linden | Authors: Xi Yang, Xinqi Zhou, Fei Xin, Benjamin Becker, David Linden and Dennis Hernaus | Summary: Abstract Age-associated changes in brain function play an important role in the development of neurodegenerative diseases. Although previous work has examined age-related changes in static functional connectivity (FC), accumulating evidence suggests that advancing age […]


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Peptaibol Production and Characterization from Trichoderma asperellum and their Action as Biofungicide.

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: Pamela Alfaro-Vargas, Alisson Bastos-Salas, Rodrigo Muñoz-Arrieta, Reinaldo Pereira-Reyes, Mauricio Redondo-Solano, Julián Fernández, Aníbal Mora-Villalobos and José Pablo López-Gómez | Summary: Abstract Peptaibols (Paib), are a class of biologically active peptides isolated from soil, fungi and molds, which have interesting properties as antimicrobial agents. Paib production was optimized in […]


Continue.. Peptaibol Production and Characterization from Trichoderma asperellum and their Action as Biofungicide.