A positively Tuned Voltage Indicator Reveals Electrical Correlates of Calcium Activity in the Brain

Kavli Affiliate: Attila Losonczy | Authors: S. Wenceslao Evans, Dongqing Shi, Mariya Chavarha, Mark H. Plitt, Jiannis Taxidis, Blake Madruga, Siri C. van Keulen, Michelle M. Pang, Sharon Su, Fuu-Jiun Hwang, Guofeng Zhang, Austin Reese, Lagnajeet Pradhan, Jiang Lan Fan, Sungmoo Lee, Yu Liu, Carl-Mikael Suomivuori, Dongyun Jiang, Adrian Negrean, Sui Wang, Na Ji, Thomas […]


Continue.. A positively Tuned Voltage Indicator Reveals Electrical Correlates of Calcium Activity in the Brain

HERBS: Histological E-data Registration in rodent Brain Spaces

Kavli Affiliate: Jonathan Whitlock, Jingyi Guo, Pearl Saldanha | Authors: Jingyi Guo Fuglstad, Pearl Saldanha, Jacopo Paglia and Jonathan R. Whitlock | Summary: Abstract Recording technologies for rodents have seen huge advances in the last decade, allowing users to sample thousands of neurons simultaneously from multiple brain regions. This has prompted the need for digital […]


Continue.. HERBS: Histological E-data Registration in rodent Brain Spaces

Signatures of visuospatial information foraging during learning of complex environments

Kavli Affiliate: Daphna Shohamy | Authors: David L Barack, Akram Bakkour, Daphna Shohamy and C Daniel Salzman | Summary: Abstract In the real world, making sequences of decisions to achieve goals often depends upon the ability to learn aspects of the environment that are not directly perceptible. Learning these so-called latent features requires seeking information […]


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Canonical retinotopic shifts under an inverse force field explain predictive remapping

Kavli Affiliate: Michael Keiser | Authors: Laura M Gunsalus, Michael J. Keiser and Katherine S Pollard | Summary: ABSTRACT Predictive remapping — the ability of cells in retinotopic brain areas to transiently exhibit spatio-temporal retinotopic shifts beyond the spatial extent of their classical receptive fields — has been proposed as a primary mechanism that stabilizes […]


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Rapid fluctuations in functional connectivity of cortical networks encode spontaneous

Kavli Affiliate: Michael Crair, Jessica Cardin | Authors: Hadas Benisty, Daniel Barson, Andrew H. Moberly, Sweyta Lohani, Ronald R. Coifman, Gal Mishne, Michael C. Crair, Jessica A. Cardin and Michael J. Higley | Summary: Abstract Experimental work across a variety of species has demonstrated that spontaneously generated behaviors are robustly coupled to variation in neural […]


Continue.. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous

Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior

Kavli Affiliate: Jessica Cardin & Michael Higley | Authors: Hadas Benisty, Andrew H Moberly, Sweyta Lohani, Daniel Barson, Ronald R Coifman, Gal Mishne, Jessica A Cardin and Michael J Higley | Summary: Abstract Experimental work across a variety of species has demonstrated that spontaneously generated behaviors are robustly coupled to variation in neural activity within […]


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Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus

Kavli Affiliate: Arnold Kriegstein | Authors: Brian R Herb, Hannah J Glover, Aparna Bhaduri, Carlo Colantuoni, Tracy L Bale, Kimberly Siletti, Sten Linnarsson, Rebecca D Hodge, Ed Lein, Arnold Kriegstein, Claudia Doege and Seth A Ament | Summary: Abstract The development and diversity of neuronal subtypes in the human hypothalamus has been insufficiently characterized. We […]


Continue.. Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus

Using Biological Constraints to Improve Prediction in Precision Oncology

Kavli Affiliate: Donald Geman, Laurent Younes | Authors: Mohamed Omar, Wikum Dinalankara, Lotte Mulder, Tendai Coady, Claudio Zanettini, Eddie Luidy Imada, Laurent Younes, Donald Geman and Luigi Marchionni | Summary: Abstract Many gene signatures have been developed by applying machine learning (ML) on omics profiles, however, their clinical utility is often hindered by limited interpretability […]


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Heritable differences in synaptic zinc-transporter levels drive variation in learned birdsong

Kavli Affiliate: Michael Brainard | Authors: DG. Mets, W. H. Mehaffey, B. M. Colquitt and M. S. Brainard | Summary: Abstract The authors have withdrawn this manuscript. During revision of our manuscript, we carried out several lines of additional experiments and analyses that failed to fully support and reproduce the results previously presented in Figure […]


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Alzheimer’s-associated upregulation of mitochondria-associated ER membranes after traumatic brain injury

Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Christian Amlang, Chi-Ying Lin, Leila Montaser-Kouhsari, Natasha Desai, Ming-Kai Pan, Sheng-Han Kuo and Daphna Shohamy | Summary: Abstract Traumatic brain injury (TBI) can lead to neurodegenerative diseases such as Alzheimer’s disease (AD) through mechanisms that remain incompletely characterized. Similar to AD, TBI models present with cellular metabolic […]


Continue.. Alzheimer’s-associated upregulation of mitochondria-associated ER membranes after traumatic brain injury