Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons

Posted by klaurent Hopkins

Kavli Affiliate: Jin Kang | Authors: McSweeney, Rafael Gabriel, Kang Jin, Zhiping P. Pang, Bruce Aronow and ChangHui Pak | Summary: Loss-of-function (LOF) mutations in CASK cause severe developmental phenotypes, including microcephaly with pontine and cerebellar hypoplasia, X-linked intellectual disability, and autism. Unraveling the pathogenesis of CASK-related disorders has been challenging due to limited human […]


Continue.. Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons

Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

Posted by klaurent UCSD / Salk

Kavli Affiliate: David Kleinfeld | Authors: Abhi Aggarwal, Rui Liu, Yang Chen, Amelia J Ralowicz, Samuel J Bergerson, Filip Tomaska, Timothy L Hanson, Jeremy P Hasseman, Daniel Reep, Getahun Tsegaye, Pantong Yao, Xiang Ji, Marinus Kloos, Deepika Walpita, Ronak Patel, Paul W Tilberg, Boaz Mohar, The GENIE Project Team, Loren L Looger, Jonathan S Marvin, […]


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Insulin/IGF Signaling Regulates Presynaptic Glutamate Release in Aversive Olfactory Learning

Posted by klaurent Rockefeller

Kavli Affiliate: Cornelia Bargmann | Authors: Du Cheng, James Lee, Maximillian Brown, Margaret S. Ebert, Masahiro Tomioka, Yuichi Iino and Cornelia I Bargmann | Summary: Information flow through neural circuits is continuously modified by context-dependent learning. In the nematode Caenorhabditis elegans, pairing specific odors with food deprivation results in aversion to the odor. Here we […]


Continue.. Insulin/IGF Signaling Regulates Presynaptic Glutamate Release in Aversive Olfactory Learning

Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled

Posted by klaurent UCSD / Salk

Kavli Affiliate: Samuel Pfaff | Authors: Remi Ronzano, Sophie Skarlatou, Bianca K Barriga, B. Anne Bannatyne, Gardave Singh Bhumbra, Joshua David Foster, Jeffrey Moore, Camille Lancelin, Amanda Pocratsky, Mustafa Gorkem Ozyurt, Calvin Chad Smith, Andrew J. Todd, David J. Maxwell, Andrew J. Murray, Samuel L Pfaff, Robert M. Brownstone, Niccolo’ Zampieri and Marco Beato | […]


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Transient oscillations of neural firing rate associated with routing of evidence in a perceptual decision

Posted by klaurent Columbia

Kavli Affiliate: Michael Shadlen | Authors: Naomi N Odean, Mehdi Sanayei and Michael N Shadlen | Summary: Abstract To form a perceptual decision the brain must acquire samples of evidence from the environment and incorporate them in computations that mediate choice behavior. While much is known about the neural circuits that process sensory information and […]


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Fast rule switching and slow rule updating in a perceptual categorization task

Posted by klaurent UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Flora Bouchacourt, Sina Tafazoli, Marcelo Gomes Mattar, Timothy J Buschman and Nathaniel Douglass Daw | Summary: Abstract To adapt to a changing world, we must be able to switch between rules already learned and, at other times, learn rules anew. Often we must do both at the same time, […]


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A retroviral origin of vertebrate myelin

Posted by klaurent UCSF

Kavli Affiliate: David Rowitch | Authors: Tanay Ghosh, Rafael G Almeida, Chao Zhao, Abdelkrim Mannioui, Elodie Martin, Alex Fleet, Ginez Gonzalez M, David H Rowitch, Katherine Stott, Ian Adams, Bernard Zalc, Nick Goldman, David A Lyons and Robin JM Franklin | Summary: Abstract Myelin, the insulating sheath that surrounds neuronal axons, is produced by oligodendrocytes […]


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Laminar Mechanisms of Saccadic Suppression in Primate Visual Cortex

Posted by klaurent UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Sachira Denagamage, Mitchell P. Morton, John H. Reynolds, Monika P. Jadi and Anirvan S. Nandy | Summary: Saccades are a ubiquitous and crucial component of our visual system, allowing for the efficient deployment of the fovea and its accompanying neural resources. Initiation of a saccade is known to cause […]


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Co-Delivery of Synergistic Antimicrobials with Polyelectrolyte Nanocomplexes to Treat Bacterial Biofilms and Lung Infections

Posted by klaurent UCSF

Kavli Affiliate: Tejal Desai | Authors: Joel A Finbloom, Preethi Raghavan, Michael Kwon, Bhushan N Kharbikar, Michelle A Yu and Tejal A Desai | Summary: Abstract New approaches are needed to treat bacterial biofilm infections, particularly those of Pseudomonas aeruginosa (PA), which have high rates of antimicrobial resistance and are commonly found in chronic wound […]


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Transcriptional and mutational signatures of the aging germline

Posted by klaurent Rockefeller

Kavli Affiliate: Li Zhao | Authors: Evan Witt, Christopher B Langer, Nicolas Svetec and Li Zhao | Summary: Abstract Aging is a complex biological process that is accompanied by changes in gene expression and mutational load. In many species, including humans, older fathers pass on more paternally-derived de novo mutations; however, the cellular basis and […]


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