Multimodal monitoring of human cortical organoids implanted in mice using transparent graphene microelectrodes reveal functional connection between organoid and mouse visual cortex

Posted by klaurent UCSD / Salk

Kavli Affiliate: Fred Gage | Authors: Madison Wilson, Martin Thunemann, Xin Liu, Yichen Lu, Francesca Puppo, Jason Adams, Jeong-Hoon Kim, Donald Pizzo, Srdjan Djurovic, Ole Andreassen, Abed Mansour, Fred H. Gage, Alysson R Muotri, Anna Devor and Duygu Kuzum | Summary: Human cortical organoids, three-dimensional neuronal cell cultures derived from human induced pluripotent stem cells, […]


Continue.. Multimodal monitoring of human cortical organoids implanted in mice using transparent graphene microelectrodes reveal functional connection between organoid and mouse visual cortex

Sex-specific age-related changes in excitatory and inhibitory intra-cortical circuits in mouse primary auditory cortex

Posted by klaurent Hopkins

Kavli Affiliate: Patrick Kanold | Authors: Binghan Xue, Joseph P-Y Kao and Patrick O Kanold | Summary: A common impairment in aging is age-related hearing loss (presbycusis), which manifests as impaired spectrotemporal processing. Aging is accompanied by alteration in normal inhibitory (GABA) neurotransmission and changes in excitatory (NMDA and AMPA) synapses in the auditory cortex […]


Continue.. Sex-specific age-related changes in excitatory and inhibitory intra-cortical circuits in mouse primary auditory cortex

Klarigi: Characteristic Explanations for Semantic Data

Posted by klaurent NTNU

Kavli Affiliate: Simon Ball | Authors: Luke T Slater, John A Williams, Paul N Schofield, Sophie Russell, Samantha C Pendleton, Andreas Karwath, Hilary Fanning, Simon Ball, Robert T Hoehndorf and Georgios V Gkoutos | Summary: Abstract Background Annotation of biomedical entities with ontology terms facilitates the use of background knowledge in analysis. Described entities may […]


Continue.. Klarigi: Characteristic Explanations for Semantic Data

Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates

Posted by klaurent Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Daehun Park, Yumei Wu, Aaron Baublis and Pietro De Camilli | Summary: Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid-like properties. We show that unlike synaptophysin, other major integral SV membrane […]


Continue.. Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates

Closed-loop control and recalibration of place cells by optic flow

Posted by klaurent Hopkins

Kavli Affiliate: James Knierim | Authors: Manu S Madhav, Ravikrishnan P Jayakumar, Brian Y Li, Francesco Savelli, James J Knierim and Noah J Cowan | Summary: Understanding the interplay between sensory input, endogenous neural dynamics, and behavioral output is key toward understanding the principles of neural computation. Hippocampal place cells are an ideal system to […]


Continue.. Closed-loop control and recalibration of place cells by optic flow

Functional network properties derived from widefield calcium imaging differ with wakefulness and across cell type

Posted by klaurent Yale

Kavli Affiliate: Michael Crair | Authors: David O’Connor, Francesca Mandino, Xilin Shen, Corey Horien, Xinxin Ge, Peter Herman, Michael Crair, Xenophon Papademetris, Evelyn MR Lake and Robert Todd Constable | Summary: To improve bench-to-bedside translation, it is integral that knowledge flow bidirectionally from – animal models to humans, and vice versa. This will be facilitated […]


Continue.. Functional network properties derived from widefield calcium imaging differ with wakefulness and across cell type

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

Posted by klaurent UCSF

Kavli Affiliate:Allan Basbaum | Authors: Isha Singh, Anubha Seth, Christian B. Billesbolle, Joao Braz, Ramona M. Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Parnian Lak, Henry R O’Donnell, Walter R Sandtner, Bryan L. Roth, Allan Basbaum, William C Wetsel, Aashish Manglik, Brian K. Shoichet and Gary Rudnick | Summary: The serotonin […]


Continue.. Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

An Internal Model of Sensorimotor Context in Freely Swimming Electric Fish

Posted by klaurent Columbia

Kavli Affiliate: Nathaniel Sawtell | Authors: Avner Wallach and Nathaniel B Sawtell | Summary: Nervous systems are hypothesized to learn and store internal models that predict the sensory consequences of motor actions. However, little is known about the neural mechanisms for generating accurate predictions under real-world conditions in which the sensory consequences of action depend […]


Continue.. An Internal Model of Sensorimotor Context in Freely Swimming Electric Fish

A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response.

Posted by klaurent UCSF

Kavli Affiliate: Peter Walter | Authors: Advait Subramanian, Lan Wang, Tom Moss, Mark Voorhies, Smriti Sangwan, Erica Stevenson, Ernst H Pulido, Samentha Kwok, Nevan J Krogan, Danielle L Swaney, Stephen N Floor, Anita Sil, Peter Walter and Shaeri Mukherjee | Summary: Pathogens often secrete proteins or nucleic acids that mimic the structure and/or function of […]


Continue.. A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response.

Motor cortical influence relies on task-specific activity covariation

Posted by klaurent Columbia

Kavli Affiliate: Costa, Rui | Authors: Claire L Warriner, Samaher Fageiry, Shreya Saxena, Rui M Costa and Andrew Miri | Summary: During limb movement, spinal circuits facilitate the alternating activation of antagonistic flexor and extensor muscles. Yet antagonist cocontraction is often required to stabilize joints, like when loads are handled. Previous results suggest that these […]


Continue.. Motor cortical influence relies on task-specific activity covariation