Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall

Kavli Affiliate: Eric Halgren | Authors: Charles W Dickey, Ilya A Verzhbinsky, Xi Jiang, Burke Q Rosen, Sophie Kajfez, Brittany Stedelin, Jerry J Shih, Sharona Ben-Haim, Ahmed M Raslan, Emad N Eskandar, Jorge Gonzalez-Martinez, Sydney S Cash and Eric Halgren | Summary: Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in […]


Continue.. Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall

The incentive circuit: memory dynamics in the mushroom body of Drosophila melanogaster

Kavli Affiliate: Michael Nitabach | Authors: Evripidis Gkanias, Li Yan McCurdy, Michael N Nitabach and Barbara Webb | Summary: Insects adapt their response to stimuli, such as odours, according to their pairing with positive or negative reinforcements, such as sugar or shock. Recent electrophysiological and imaging findings in Drosophila melanogaster allow detailed examination of the […]


Continue.. The incentive circuit: memory dynamics in the mushroom body of Drosophila melanogaster

Dynamic Synchronization between Hippocampal Spatial Representations and the Stepping Rhythm

Kavli Affiliate: Loren Frank | Authors: Abhilasha Joshi, Eric L. Denovellis, Abhijith Mankili, Yagiz Meneksedag, Thomas Davidson, Anna K Gillespie, Jennifer Ann Guidera, Demetris Roumis and Loren M. Frank | Summary: The hippocampus is a vertebrate brain structure that expresses spatial representations1 and is critical for navigation2,3. Navigation in turn intricately depends on locomotion; however, […]


Continue.. Dynamic Synchronization between Hippocampal Spatial Representations and the Stepping Rhythm

Cyclic, condition-independent activity in primary motor cortex predicts corrective movement behavior

Kavli Affiliate: Sridevi Sarma | Authors: Adam G Rouse, Marc H Schieber and Sridevi V Sarma | Summary: Reaching movements are known to have large condition-independent neural activity and cyclic neural dynamics. A new precision center-out task was performed by rhesus macaques to test the hypothesis that cyclic, condition-independent neural activity in the primary motor […]


Continue.. Cyclic, condition-independent activity in primary motor cortex predicts corrective movement behavior

Reduced Dimension, Biophysical Neuron Models Constructed From Observed Data

Kavli Affiliate: Henry Abarbanel | Authors: Randall E Clark, Lawson Fuller, Jason A Platt and Henry Abarbanel | Summary: Using methods from nonlinear dynamics and interpolation techniques from applied mathematics, we show how to use data alone to construct discrete time dynamical rules that forecast observed neuron properties. These data may come from from simulations […]


Continue.. Reduced Dimension, Biophysical Neuron Models Constructed From Observed Data

Face familiarity detection with complex synapses

Kavli Affiliate: Stefano Fusi | Authors: Li Ji-An, Fabio Stefanini, Marcus K Benna and Stefano Fusi | Summary: Synaptic plasticity is a complex phenomenon involving multiple biochemical processes that operate on different timescales. We recently showed that this complexity can greatly increase the memory capacity of neural networks when the variables that characterize the synaptic […]


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Long-term learning transforms prefrontal cortex representations during working memory

Kavli Affiliate: Anastasia Kiyonaga | Authors: Jacob Miller, Arielle Tambini, Anastasia Kiyonaga and Mark D’Esposito | Summary: The lateral prefrontal cortex (lPFC) is reliably active during working memory (WM) across human and animal models, but the role of lPFC in successful WM is under debate. For instance, non-human primate (NHP) electrophysiology research finds that lPFC […]


Continue.. Long-term learning transforms prefrontal cortex representations during working memory

Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brain.

Kavli Affiliate: Jose Suarez Lopez | Authors: Matthew Stratton, Jose Alberto Lopez-Dominguez, Alessandro Canella, Jon J Ramsey and Gino A Cortopassi | Summary: Aging is associated with multiple neurodegenerative conditions that severely limit quality of life and shorten lifespan. Studies in rodents indicate that in addition to extending lifespan, the ketogenic diet improves cognitive function […]


Continue.. Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brain.

A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis

Kavli Affiliate: Anna Molofsky, Bjoern Schwer | Authors: Leah C. Dorman, Phi T. Nguyen, Caroline C. Escoubas, Ilia D. Vainchtein, Yinghong Xiao, Peter V. Lidsky, Haruna Nakajo, Nicholas J. Silva, Christian Lagares-Linares, Ellen Y. Wang, Sunrae E. Taloma, Beatriz Cuevas, Hiromi Nakao-Inoue, Brianna M. Rivera, Bjoern Schwer, Carlo Condello, Raul Andino, Tomasz J. Nowakowski and […]


Continue.. A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis

B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates

Kavli Affiliate: Robert Edwards | Authors: Md. Alamgir Hossain, Kara Anasti, Brian Watts, Kenneth Cronin, Advaiti Pai Kane, R.J. Edwards, David Easterhoff, Jinsong Zhang, Wes Rountree, Yaneth Ortiz, Laurent Verkoczy, Michael Reth and S. Munir Alam | Summary: HIV-1 Envelope (Env) proteins designed to induce neutralizing antibody responses allow study of the role of affinities […]


Continue.. B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates