Persistence of Cajal-Retzius cells in the postnatal hippocampus is required for development of dendritic spines of CA1 pyramidal cells

Posted by klaurent NTNU

Kavli Affiliate: Maximiliano Nigro, Giulia Quattrocolo, Keagan Dunville | Authors: Ingvild Lynneberg Glaerum, Keagan Dunville, Nicola Pietro Montaldo, Hinako Kirikae, Maximiliano Jose Nigro, Pal Saetrom, Barbara Van Loon and Giulia Quattrocolo | Summary: Cajal-Retzius (CR) cells are a transient type of neuron that populate the postnatal hippocampus. The role of transient cell types and circuits […]


Continue.. Persistence of Cajal-Retzius cells in the postnatal hippocampus is required for development of dendritic spines of CA1 pyramidal cells

Scaled-expansion of the membrane associated cytoskeleton requires conserved kinesin adaptors

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: Oliver Glomb, Grace Swaim, Pablo Munoz LLancao, Christopher Lovejoy, Sabyasachi Sutradhar, Junhyun Park, Youjun Wu, Marc Hammarlund, Jonathon Howard, Shawn M. Ferguson and Shaul Yogev | Summary: A periodic lattice of actin rings and spectrin tetramers scaffolds the axonal membrane. How spectrin is delivered to this structure to scale […]


Continue.. Scaled-expansion of the membrane associated cytoskeleton requires conserved kinesin adaptors

TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

Posted by klaurent UCSF

Kavli Affiliate:Allan Basbaum | Authors: Wendy W.S. Yue, Lin Yuan, Joao M. Bráz, Allan I. Basbaum and David Julius | Summary: TRPV1, a capsaicin- and heat-sensitive ion channel, is expressed by peripheral nociceptors and has been implicated in various inflammatory and neuropathic pain conditions. Although pharmacological modulation of TRPV1 has attracted therapeutic interest, their utility […]


Continue.. TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina

Posted by klaurent NTNU

Kavli Affiliate: Jingyi Guo | Authors: Yanling xin, Qinghai He, Huilin Liang, Jingyi Guo, Qi Zhong, Ke Zhang, Jinyan Li, Yizhi Liu and Shuyi Chen | Summary: N6-methyladenosine (m6A) is the most prevalent mRNA internal modification and has been shown to regulate the development, physiology and pathology of various tissues. However, the functions of the […]


Continue.. m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina

Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses

Posted by klaurent UCSF

Kavli Affiliate: Saul Kato | Authors: Rashmi Chandra, Fatima Farah, Fernando Munoz-Lobato, Anirudh Bokka, Kelli L Benedetti, Chantal Brueggemann, Fatema Mashel Saifuddin, Julia M. Miller, Joy Li, Eric Chang, Aruna Varshney, Vanessa Jiminez, Anjana Baradwaj, Cibelle Nassif, Sara Alladin, Kristine E Andersen, Veronica Bi, Sarah K Nordquist, Raymond L Dunn, Bryan Tsujimoto, Alan Tran, Alexander […]


Continue.. Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses

TMEM106B is increased in Multiple Sclerosis plaques, and deletion causes accumulation of lipid after demyelination

Posted by klaurent Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C DuBois, John R Corboy, Stephen M. Strittmatter, Hillary Guzik, Sarah Graff and Rashed M Nagra | Summary: During inflammatory, demyelinating diseases such as multiple sclerosis (MS) axonal damage is prevalent early in the disease course. Axonal damage includes swellings, defects […]


Continue.. TMEM106B is increased in Multiple Sclerosis plaques, and deletion causes accumulation of lipid after demyelination

Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

Posted by klaurent Hopkins

Kavli Affiliate: Peter Searson | Authors: Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Renee F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao and Peter C. Searson | Summary: The blood-brain barrier (BBB) plays a pivotal role in brain health and disease. In the […]


Continue.. Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

A neural mechanism for terminating decisions

Posted by klaurent Columbia

Kavli Affiliate: Michael Shadlen | Authors: Gabriel M Stine, Eric M Trautmann, Danique Jeurissen and Michael N Shadlen | Summary: The brain makes decisions by accumulating evidence until there is enough to stop and choose. Neural mechanisms of evidence accumulation are well established in association cortex, but the site and mechanism of termination is unknown. […]


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Minute-scale oscillatory sequences in medial entorhinal cortex

Posted by klaurent NTNU

Kavli Affiliate: Edvard Moser, May Britt Moser, Ragnhild Leifsdottir, Horst Obenhaus | Authors: Soledad Gonzalo Cogno, Horst A. Obenhaus, Ragnhild Irene Jacobsen, Flavio Donato, May-Britt Moser and Edvard I. Moser | Summary: The medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity […]


Continue.. Minute-scale oscillatory sequences in medial entorhinal cortex

A Spectrum of Time Horizons for Dopamine Signals

Posted by klaurent UCSF

Kavli Affiliate: Joshua Berke | Authors: Wei Wei, Ali Mohebi and Joshua Berke | Summary: Dopamine input to striatum can encode reward prediction error, a critical signal for updating predictions of future rewards. However, it is unclear how this mechanism handles the need to make predictions, and provide feedback, over multiple time horizons: from seconds […]


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