The transcription regulator Lmo3 is required for cell fate specification in the external globus pallidus

Kavli Affiliate: John Rubenstein | Authors: Shiona Biswas, C. Savio Chan, John L.R. Rubenstein and Lin Gan | Summary: The external globus pallidus (Gpe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action. Changes in the firing of GPe neurons are associated with both […]


Continue.. The transcription regulator Lmo3 is required for cell fate specification in the external globus pallidus

Physical resilience in the brain: The effect of white matter disease on brain networks in cognitively normal older adults

Kavli Affiliate: Michael Miller | Authors: Blake R Neyland, Samuel N Lockhart, Robert G Lyday, Laura D Baker, Elizabeth P Handing, Michael E Miller, Stephen B Kritchevsky, Paul J Laurienti and Christina E Hugenschmidt | Summary: BACKGROUND: Physical resilience with age is considered a key feature of healthy aging, but current understanding of the neural […]


Continue.. Physical resilience in the brain: The effect of white matter disease on brain networks in cognitively normal older adults

Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

Kavli Affiliate: Wesley Thompson | Authors: James Talwar, David Laub, Meghana Pagadala, Andrea Castro, McKenna Lewis, Georg E. Luebeck, Bryan Gorman, Cuiping Pan, Frederick N. Dong, Kyriacos Markianos, Richard Hauger, Saiju Pyarajan, Philip S. Tsao, Gerald P. Morris, Rany M. Salem, Wesley K. Thompson, Kit Curtius, Maurizio Zanetti and Hannah Carter | Summary: Autoimmunity and […]


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Hippocampus as a generative circuit for predictive coding of future sequences

Kavli Affiliate: Terrence Sejnowski | Authors: Yusi Chen, Huanqiu Zhang and Terrence J Sejnowski | Summary: The interaction between hippocampus and cortex is key to memory formation and representation learning. Based on anatomical wiring and transmission delays, we proposed a self-supervised recurrent neural network (PredRAE) with a predictive reconstruction loss to account for the cognitive […]


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Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes

Kavli Affiliate: Carey Priebe, Joshua Vogelstein | Authors: Benjamin D Pedigo, Michael Winding, Carey E Priebe and Joshua T Vogelstein | Summary: Graph matching algorithms attempt to find the best correspondence between the nodes of two networks. These techniques have previously been used to match individual neurons in nanoscale connectomes – in particular, to find […]


Continue.. Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes

Guided construction of single cell reference for human and mouse lung

Kavli Affiliate: Jin Kang | Authors: Minzhe Guo, Michael P. Morley, Yixin Wu, Yina Du, Shuyang Zhao, Andrew Wagner, Michal Kouril, Kang Jin, Nathan Gaddis, Joseph A. Kitzmiller, Kathleen Stewart, Maria C. Basil, Susan M. Lin, Yun Ying, Apoorva Babu, Kathryn A. Wikenheiser-Brokamp, Kyu Shik Mun, Anjaparavanda P. Naren, Sara Lin, Geremy Clair, Joshua N. […]


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Neural learning rules for generating flexible predictions and computing the successor representation

Kavli Affiliate: Larry Abbott | Authors: Ching Fang, Dmitriy Aronov, Larry F Abbott and Emily Mackevicius | Summary: The predictive nature of the hippocampus is thought to be useful for memory-guided cognitive behaviors. Inspired by the reinforcement learning literature, this notion has been formalized as a predictive map called the successor representation (SR). The SR […]


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Interactive Neurorobotics: Behavioral and Neural Dynamics of Agent Interactions

Kavli Affiliate: Andrea Chiba | Authors: Eric J Leonardis, Leo Breston, Rhiannon Lucero-Moore, Leigh Sena, Raunit Kohli, Luisa Schuster, Lacha Barton-Gluzman, Laleh K Quinn, Janet Wiles and Andrea Chiba | Summary: Interactive neurorobotics is a subfield which characterizes brain responses evoked during interaction with a robot, and their relationship with the behavioral responses. Gathering rich […]


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Immunomodulatory Extracellular Matrix Hydrogel Mitigates Scar Formation in a Model of Tongue Fibrosis.

Kavli Affiliate: Karen Christman | Authors: mma I Zelus, Aaron Panduro, Marianna Alperin, Andrew M Vahabzadeh-Hagh and Karen L Christman | Summary: Background: While head and neck cancer treatment regimens, including surgical resection, irradiation, and chemotherapy, are effective at removing tumors, they lead to muscle atrophy, denervation, and fibrosis, contributing to the pathogenesis of tongue […]


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Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death during Mammary Gland Involution

Kavli Affiliate: Shawn Ferguson | Authors: Jaekwang Jeong, Jongwon Lee, Gabriel Talaia, Wonnam Kim, Junho Song, Kwangmin Yoo, David G. Gonzalez, Diana Athonvarangkul, Jaehun Shin, Pamela Dann, Ann M Haberman, Lark Kyun Kim, Shawn M. Ferguson, Jungmin Choi and John Wysolmerski | Summary: Involution of the mammary gland after lactation is a dramatic example of […]


Continue.. Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death during Mammary Gland Involution