Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jean Pierre Changeux | Authors: Sophie Shi, Solene N Lefebvre, Laurie Peverini, Adrien H Cerdan, Marc Gielen, Jean-Pierre Changeux, Marco CECCHINI and Pierre-Jean Corringer | Summary: Pentameric ligand-gated ion channel mediate signal transduction at chemical synapses by transiting between resting and open states upon neurotransmitter binding. Here, we investigate the gating transition of […]


Continue.. Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Spatiotemporal recruitment of inhibition and excitation in the mammalian cortex during electrical stimulation

Posted by klaurent UCSF

Kavli Affiliate: Michael Stryker | Authors: Maria C. Dadarlat, Yujiao Jennifer Sun and Michael P Stryker | Summary: Electrical stimulation has emerged as a powerful and precise treatment in which to modulate aberrant neural activity patterns common in neural dysfunction and disease; however, the physiological process involved in microstimulation is poorly understood, particularly regarding the […]


Continue.. Spatiotemporal recruitment of inhibition and excitation in the mammalian cortex during electrical stimulation

All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals

Posted by klaurent Rockefeller

Kavli Affiliate: Cori Bargmann | Authors: Amelie CF Bergs, Jana F Liewald, Silvia Rodriguez-Rozada, Qiang Liu, Christin Wirt, Artur Bessel, Nadja Zeitzschel, Hilal Durmaz, Adrianna Nozownik, Johannes Vierock, Cori Bargmann, Peter Hegemann, J. Simon Wiegert and Alexander Gottschalk | Summary: Optogenetics are used to stimulate or inhibit neurons. Because optogenetic stimulation is typically static, neurons […]


Continue.. All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals

Recording large-scale, cellular-resolution neuronal activity from freely-moving mice

Posted by klaurent Columbia

Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Sarah Holden, Julie Borovicka, Jacob Icardi, Davina Patel, Rushik Patel, Jacob Raber and Hod Dana | Summary: To date, recording of cellular-resolution activity from awake mice has required either head fixation under a microscope or attaching a miniaturized device to the skull, both of which inevitably affect […]


Continue.. Recording large-scale, cellular-resolution neuronal activity from freely-moving mice

A multifaceted architectural framework of the mouse claustrum complex

Posted by klaurent NTNU

Kavli Affiliate: Clifford Kentros, Menno Witter, Stefan Blankvoort | Authors: Joachim Schweder Grimstvedt, Andrew M. Shelton, Anna Hoerder-Suabedissen, David K. Oliver, Christin H. Berndtsson, Stefan Blankvoort, Rajeevkumar Raveendran Nair, Adam M. Packer, Menno P. Witter and Clifford G. Kentros | Summary: Accurate anatomical characterizations are necessary to investigate neural circuitry on a fine scale, but […]


Continue.. A multifaceted architectural framework of the mouse claustrum complex

Recording gene expression order in DNA by CRISPR addition of retron barcodes

Posted by klaurent UCSF

Kavli Affiliate: Seth Shipman | Authors: Santi Bhattarai-Kline, Sierra K. Lear, Chloe B. Fishman, Santiago C. Lopez, Elana R. Lockshin, Max G. Schubert, Jeff Nivala, George Church and Seth L. Shipman | Summary: Biological processes depend on the differential expression of genes over time, but methods to make physical recordings of these processes are limited. […]


Continue.. Recording gene expression order in DNA by CRISPR addition of retron barcodes

Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1

Posted by klaurent Hopkins

Kavli Affiliate: James Knierim | Authors: William Hockeimer, Ruo-Yah Lai, Maanasa Natrajan, William Snider and James J. Knierim | Summary: The hippocampus is believed to encode episodic memory by binding information about the content of experience within a spatial framework encoding the location of that experience. Previous work implies a distinction between positional inputs to […]


Continue.. Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1

Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition

Posted by klaurent UCSF

Kavli Affiliate: Susanna Rosi, Peter Walter, Michael Stryker | Authors: Elma S. Frias, Mahmood S. Hoseini, Karen Krukowski, Maria Serena Paladini, Katherine Grue, Gonzalo Ureta, Kira D.A. Rienecker, Peter Walter, Michael P. Stryker and Susanna Rosi | Summary: Traumatic brain injury (TBI) is a leading cause of long-term neurological disability in the world and the […]


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Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites

Posted by klaurent UCSF

Kavli Affiliate: Kevin Bender | Authors: Andrew D. Nelson, Amanda M. Catalfio, Julie M. Gupta, Lia Min, René N. Caballero-Florán, Kendall P. Dean, Carina C. Elvira, Kimberly D. Derderian, Henry Kyoung, Atehsa Sahagun, Stephan J Sanders, Kevin Bender and Paul M Jenkins | Summary: Dysfunction in sodium channels and their ankyrin scaffolding partners have both […]


Continue.. Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites

Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents

Posted by klaurent NTNU

Kavli Affiliate: Menno Witter | Authors: Shinya Ohara, Märt Rannap, Ken-Ichiro Tsutsui, Andreas Draguhn, Alexei V. Egorov and Menno P. Witter | Summary: The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro […]


Continue.. Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents