Functional network organization of the mouse cortex determined by wide-field fluorescence imaging shares some —but not all— properties revealed with simultaneous fMRI-BOLD

Posted by klaurent Yale

Kavli Affiliate: Michael Crair | Authors: Hadi Vafaii, Francesca Mandino, Gabriel Desrosiers-Gregoire, David O’Connor, Xilin Shen, Xinxin Ge, Peter Herman, Fahmeed Hyder, Xenophon Papademetris, Mallar Chakravarty, Michael Crair, Robert T Constable, Evelyn MR Lake and Luiz Pessoa | Summary: SUMMARY Understanding the organization of large-scale brain networks remains a central problem in neuroscience. Work in […]


Continue.. Functional network organization of the mouse cortex determined by wide-field fluorescence imaging shares some —but not all— properties revealed with simultaneous fMRI-BOLD

The TRPV Channel OSM-9 is Required for Sleep-Dependent Olfactory Memory and is Expressed in Sensory Neurons That Typically Do Not Promote Butanone Attraction

Posted by klaurent UCSF

Kavli Affiliate: Noelle Letoile, Saul Kato | Authors: Kelli L. Benedetti, Fatema A Saifuddin, Julia M Miller, Kevin Daigle, Rashmi Chandra, Alec Chen, Christine Lin, Angel Jacob Garcia, Burhanuddin Calcuttawala, Angelica Tovar, Raymond L Dunn, Jackson Borchardt, Julia A Kaye, Bo Zhang, Saul Kato, Maria E Gallegos, Torsten Wittmann and Noelle L’Etoile | Summary: SUMMARY […]


Continue.. The TRPV Channel OSM-9 is Required for Sleep-Dependent Olfactory Memory and is Expressed in Sensory Neurons That Typically Do Not Promote Butanone Attraction

Neural circuit-wide analysis of gene expression during deafening-induced destabilization of birdsong

Posted by klaurent UCSF

Kavli Affiliate: Michael Brainard | Authors: Bradley M Colquitt, Kelly Li, Foad Green, Robert J Veline and Michael S Brainard | Summary: SUMMARY Sensory feedback is required for stable execution of learned motor skills, and its loss can severely disrupt motor performance. The neural mechanisms that mediate sensorimotor stability have been extensively studied at systems […]


Continue.. Neural circuit-wide analysis of gene expression during deafening-induced destabilization of birdsong

Interactive auditory task reveals complex sensory-action integration in mouse primary auditory cortex

Posted by klaurent Hopkins

Kavli Affiliate: Patrick Kanold | Authors: Ji Liu and Patrick O Kanold | Summary: SUMMARY Predictive coding theory postulates that the brain achieves perception by actively making predictions about the incoming sensory information and correcting them if errors signals arise. These signals are likely the most relevant when the individual is actively interacting with the […]


Continue.. Interactive auditory task reveals complex sensory-action integration in mouse primary auditory cortex

Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders

Posted by dbos Rockefeller

Kavli Affiliate: Timothy A. Ryan | Authors: Mukesh Kumar, Justin Knapp, Kallol Gupta and Timothy A Ryan | Summary: Recent advances have expanded the role of lipid droplets (LDs) beyond passive lipid storage, implicating their involvement in various metabolic processes across mammalian tissues. Neuronal LDs, long debated in existence, have been identified in several neural […]


Continue.. Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders

Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson’s disease patients with PINK1 and PARK2 mutations

Posted by klaurent UCSD / Salk

Kavli Affiliate: Fred Gage | Authors: Utkarsh Tripathi, Idan Rosh, Ran Ben Ezer, Ritu Nayak, Ashwani Choudhary, Jose Djamus, Andreea Manole, Henry Houlden, Fred H. Gage and Shani Stern | Summary: Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Primary symptoms of PD arise with the loss of dopaminergic (DA) neurons in […]


Continue.. Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson’s disease patients with PINK1 and PARK2 mutations

Two types of locus coeruleus norepinephrine neurons drive reinforcement learning

Posted by klaurent Hopkins

Kavli Affiliate: Jeremiah Cohen | Authors: Zhixiao Su and Jeremiah Y. Cohen | Summary: Abstract The cerebral cortex generates flexible behavior by learning. Reinforcement learning is thought to be driven by error signals in midbrain dopamine neurons. However, they project more densely to basal ganglia than cortex, leaving open the possibility of another source of […]


Continue.. Two types of locus coeruleus norepinephrine neurons drive reinforcement learning

Visuomotor interactions in the mouse forebrain mediated by extrastriate cortico-cortical pathways

Posted by klaurent NTNU

Kavli Affiliate: Menno Witter, Jonathan Whitlock | Authors: Karoline Hovde, Ida V. Rautio, Andrea Marie Hegstad, Menno P. Witter and Jonathan R. Whitlock | Summary: Abstract The mammalian visual system can be broadly divided into two functional processing pathways: a dorsal stream supporting visually and spatially guided actions, and a ventral stream enabling object recognition. […]


Continue.. Visuomotor interactions in the mouse forebrain mediated by extrastriate cortico-cortical pathways

Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells

Posted by klaurent Columbia

Kavli Affiliate: Rene Hen | Authors: Sebnem N. Tuncdemir, Andres D. Grosmark, Hannah Chung, Victor M. Luna, Clay O. Lacefield, Attila Losonczy and Rene Hen | Summary: Abstract The hippocampal dentate gyrus (DG) exhibits a unique form of neural plasticity that results from continuous integration of adult born neurons, referred to as ‘adult neurogenesis’. Recent […]


Continue.. Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells

Engineered retrovirus-like Arc extracellular vesicles for the in vivo targeted delivery of mRNA into the brain

Posted by klaurent Columbia

Kavli Affiliate: Robert Hawkins | Authors: Wenchao Gu, Sijin Luozhong, Ketaki Londhe, Nadine Elkasri, Simian Cai, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Melissa Warden, Robert Langer and Shaoyi Jiang | Summary: Abstract Systemic […]


Continue.. Engineered retrovirus-like Arc extracellular vesicles for the in vivo targeted delivery of mRNA into the brain