Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in hippocampal CA3 place cells

Posted by klaurent UCSD / Salk

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Hasti Atashi and Solomon Snyder | Summary: The hippocampal CA3 subregion is a densely connected recurrent circuit that supports memory consolidation and retrieval by generating and storing sequential neuronal activity patterns that reflect recent experience. The encoding of precise temporal firing patterns in CA3 ensembles during awake-behavior […]


Continue.. Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in hippocampal CA3 place cells

Serine Racemase mediates Subventricular Zone Neurogenesis via Fatty acid Metabolism.

Posted by klaurent Hopkins

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Hasti Atashi and Solomon Snyder | Summary: The adult subventricular zone is one of the two neurogenic niches that continuously produce newborn neurons. Here we show that serine racemase (SR), an enzyme that catalyzes the racemization of L-serine to D-serine and vice versa, affects neurogenesis in the […]


Continue.. Serine Racemase mediates Subventricular Zone Neurogenesis via Fatty acid Metabolism.

Age-related learning and working memory impairment in the common marmoset

Posted by klaurent UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Courtney Glavis-Bloom, Casey R Vanderlip and John H Reynolds | Summary: Aging is the greatest risk factor for the development of neurodegenerative diseases, yet we still do not understand how the aging process leads to pathological vulnerability. The research community has relied heavily on mouse models, but the considerable […]


Continue.. Age-related learning and working memory impairment in the common marmoset

Reconstructing the cascade of language processing in the brain using the internal computations of a transformer-based language model

Posted by klaurent Columbia

Kavli Affiliate: Robert Hawkins | Authors: Sreejan Kumar, Theodore R. Sumers, Takateru Yamakoshi, Ariel Goldstein, Uri Hasson, Kenneth A. Norman, Thomas L. Griffiths, Robert D. Hawkins and Samuel A. Nastase | Summary: Piecing together the meaning of a narrative requires understanding not only the individual words but also the intricate relationships between them. How does […]


Continue.. Reconstructing the cascade of language processing in the brain using the internal computations of a transformer-based language model

Induction of senescence renders cancer cells highly immunogenic

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: Ines Marin, Olga Boix, Andrea Garcia-Garijo, isabelle Sirois, Adria Caballe, Eduardo Zarzuela, Irene Ruano, Camille Stephan-Otto Attolini, Neus Prats, Jose Alberto Lopez-Dominguez, Marta Kovatcheva, Elena Garralda, Javier Munoz, Etienne Caron, Maria Abad, Alena Gros, Federico Pietrocola and Manuel Serrano | Summary: Cellular senescence is a stress response that […]


Continue.. Induction of senescence renders cancer cells highly immunogenic

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jean Pierre Changeux | Authors: Sophie Shi, Solene N Lefebvre, Laurie Peverini, Adrien H Cerdan, Marc Gielen, Jean-Pierre Changeux, Marco CECCHINI and Pierre-Jean Corringer | Summary: Pentameric ligand-gated ion channel mediate signal transduction at chemical synapses by transiting between resting and open states upon neurotransmitter binding. Here, we investigate the gating transition of […]


Continue.. Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Spatiotemporal recruitment of inhibition and excitation in the mammalian cortex during electrical stimulation

Posted by klaurent UCSF

Kavli Affiliate: Michael Stryker | Authors: Maria C. Dadarlat, Yujiao Jennifer Sun and Michael P Stryker | Summary: Electrical stimulation has emerged as a powerful and precise treatment in which to modulate aberrant neural activity patterns common in neural dysfunction and disease; however, the physiological process involved in microstimulation is poorly understood, particularly regarding the […]


Continue.. Spatiotemporal recruitment of inhibition and excitation in the mammalian cortex during electrical stimulation

All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals

Posted by klaurent Rockefeller

Kavli Affiliate: Cori Bargmann | Authors: Amelie CF Bergs, Jana F Liewald, Silvia Rodriguez-Rozada, Qiang Liu, Christin Wirt, Artur Bessel, Nadja Zeitzschel, Hilal Durmaz, Adrianna Nozownik, Johannes Vierock, Cori Bargmann, Peter Hegemann, J. Simon Wiegert and Alexander Gottschalk | Summary: Optogenetics are used to stimulate or inhibit neurons. Because optogenetic stimulation is typically static, neurons […]


Continue.. All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals

Recording large-scale, cellular-resolution neuronal activity from freely-moving mice

Posted by klaurent Columbia

Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Sarah Holden, Julie Borovicka, Jacob Icardi, Davina Patel, Rushik Patel, Jacob Raber and Hod Dana | Summary: To date, recording of cellular-resolution activity from awake mice has required either head fixation under a microscope or attaching a miniaturized device to the skull, both of which inevitably affect […]


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A multifaceted architectural framework of the mouse claustrum complex

Posted by klaurent NTNU

Kavli Affiliate: Clifford Kentros, Menno Witter, Stefan Blankvoort | Authors: Joachim Schweder Grimstvedt, Andrew M. Shelton, Anna Hoerder-Suabedissen, David K. Oliver, Christin H. Berndtsson, Stefan Blankvoort, Rajeevkumar Raveendran Nair, Adam M. Packer, Menno P. Witter and Clifford G. Kentros | Summary: Accurate anatomical characterizations are necessary to investigate neural circuitry on a fine scale, but […]


Continue.. A multifaceted architectural framework of the mouse claustrum complex