Kavli Affiliate: Jacqueline Gottlieb | Authors: Michael Cohanpour, Mariam Aly and Jacqueline Gottlieb | Summary: Humans are immensely curious and motivated to reduce uncertainty. Inspired by studies of sensory uncertainty, we hypothesized that visual areas provide multivariate representations of uncertainty, which are read out by higher-order areas that encode confidence and, ultimately, translated into curiosity. […]
Kavli Affiliate: Samuel Pfaff | Authors: Marito Hayashi, Miriam Gullo, Gokhan Senturk, Stefania Di Costanzo, Shinji C. Nagasaki, Ryoichiro Kageyama, Itaru Imayoshi, Martyn Goulding, Samuel L. Pfaff and Graziana Gatto | Summary: Innate and goal-directed movements require a high-degree of trunk and appendicular muscle coordination to preserve body stability while ensuring the correct execution of […]
Kavli Affiliate: Alipasha Vaziri | Authors: Tobias Nöbauer, Yuanlong Zhang, Hyewon Kim and Alipasha Vaziri | Summary: Various implementations of mesoscopes provide optical access for calcium imaging across multi-millimeter fields-of-view (FOV) in the mammalian brain. However, capturing the activity of the neuronal population within such FOVs near-simultaneously and in a volumetric fashion has remained challenging […]
Kavli Affiliate: Alex Pollen | Authors: Richard She, Tyler Fair, Nathan K. Schaefer, Reuben A. Saunders, Bryan J Pavlovic, Jonathan S. Weissman and Alex A. Pollen | Summary: Comparative studies of great apes provide a window into our evolutionary past, but the extent and identity of cellular differences that emerged during hominin evolution remain largely […]
Kavli Affiliate: Samuel Pleasure | Authors: Jing Zhou, Ariele Greenfield, Rita Loudermilk, Christopher Bartley, Baouyen Tran, Chao Zhao, Hong Wang, Michael Wilson and Samuel Pleasure | Summary: NMDA receptor antibody encephalitis (NMDAR-AE) is characterized by cerebrospinal fluid (CSF)-resident anti-NMDA receptor autoantibodies that cause a wide range of neurological manifestations. Although many symptoms are responsive to […]
Kavli Affiliate: Charles M. Rice | Authors: Ariane J Brown, John Won, Raphael Wolfisberg, Ulrik Fanhoe, Nicholas Catanzaro, Ande West, Fernando Moreira, Mariana Nogeuira Batista, Martin T. Ferris, Colton Linnertz, Sarah R Leist, Cameron Nguyen, Gabriella De la Cruz, Bentley Midkiff, Yongjuan Xia, Stephanie A Montgomery, Eva Billerbeck, Jens Bukh, Troels Scheel, Charles M Rice […]
Kavli Affiliate: Joshua Berke, Loren Frank | Authors: Timothy Amos Krausz, Alison E. Comrie, Loren M. Frank, Nathaniel Douglass Daw and Joshua D. Berke | Summary: Dopamine in the nucleus accumbens helps motivate behavior based on expectations of future reward (“values”). These values need to be updated by experience: after receiving reward, the choices that […]
Kavli Affiliate: Michael W. Young | Authors: Yi Sun, Michael C Young, Claire H Woodward, Julia N Danon, Hau V Truong, Sagar Gupta, Trenton J Winters, George Burslem and Nikolaos G Sgourakis | Summary: The polymorphic nature and intrinsic instability of class I major histocompatibility complex (MHC-I) and MHC-like molecules loaded with suboptimal peptides, metabolites, […]
Kavli Affiliate: Elena Gracheva | Authors: Sarah M Mohr, Rafael Dai Pra, Maryann P Platt, Viktor V Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K Merriman, Tamas L Horvath, Sviatoslav N Bagriantsev and Elena O Gracheva | Summary: Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal […]
Kavli Affiliate: Angela Wu | Authors: Xiaomeng Wan, Jiashun Xiao, Sindy Sing Ting Tam, Mingxuan Cai, Ryohichi Sugimura, Yang Wang, Xiang Wan, Zhixiang Lin, Angela Wu and Can Yang | Summary: The rapid emergence of spatial transcriptomics (ST) technologies are revolutionizing our under-standing of tissue spatial architecture and their biology. Current ST technologies based on […]