Kavli Affiliate: Vy Thuy Nguyen | Authors: Mollie Friedlander Qian, Romina J Bevacqua, Vy M Nguyen, Xiong Liu, Weichen Zhao, Charles A Chang, Xueying Gu, Xiao-Qing Dai, Patrick E Macdonald and Seung K. Kim | Summary: ABSTRACT HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes (HNF1A-MODY) and hypomorphic HNF1A variants confer type […]
Kavli Affiliate: Edvard Moser, May-Britt Moser | Authors: Anne Nagelhus, Sebastian Andersson, Soledad Gonzalo Cogno, Edvard I. Moser and May-Britt Moser | Summary: Objects and landmarks are crucial for guiding navigation and must be integrated into the cognitive map of space. Studies of object coding in the hippocampus have primarily focused on activity of single […]
Kavli Affiliate: Menno Witter | Authors: Christiana Bjorkli, Nora Cecilie Ebbesen, Joshua B Julian, Menno P Witter, Axel Sandvig and Ioanna Sandvig | Summary: One of the neuropathological hallmarks of Alzheimer’s disease (AD) is the accumulation of amyloid-β (Aβ) plaques, which is preceded by intraneuronal build-up of toxic, aggregated Aβ during disease progression. Aβ plaques […]
Kavli Affiliate: Menno Witter, Susumu Mori, Michael Miller | Authors: Kaitlin Stouffer, Claire Chen, Sue Kulason, Eileen Xu, Menno Witter, Can Ceritoglu, Marilyn Albert, Susumu Mori, Juan Troncoso, Daniel Jacob Tward and Michael I Miller | Summary: Previous research has emphasized the unique impact of Alzheimer’s Disease (AD) pathology on the medial temporal lobe (MTL), […]
Kavli Affiliate: Simon Ball | Authors: Luke T Slater, John A Williams, Paul N Schofield, Sophie Russell, Samantha C Pendleton, Andreas Karwath, Hilary Fanning, Simon Ball, Robert T Hoehndorf and Georgios V Gkoutos | Summary: Abstract Background Annotation of biomedical entities with ontology terms facilitates the use of background knowledge in analysis. Described entities may […]
Kavli Affiliate: Clifford Kentros, Menno Witter, Stefan Blankvoort | Authors: Joachim Schweder Grimstvedt, Andrew M. Shelton, Anna Hoerder-Suabedissen, David K. Oliver, Christin H. Berndtsson, Stefan Blankvoort, Rajeevkumar Raveendran Nair, Adam M. Packer, Menno P. Witter and Clifford G. Kentros | Summary: Accurate anatomical characterizations are necessary to investigate neural circuitry on a fine scale, but […]
Kavli Affiliate: Menno Witter | Authors: Shinya Ohara, Märt Rannap, Ken-Ichiro Tsutsui, Andreas Draguhn, Alexei V. Egorov and Menno P. Witter | Summary: The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro […]
Kavli Affiliate: Maximiliano Nigro, Giulia Quattrocolo, Keagan Dunville | Authors: Ingvild Lynneberg Glaerum, Keagan Dunville, Nicola Pietro Montaldo, Hinako Kirikae, Maximiliano Jose Nigro, Pal Saetrom, Barbara Van Loon and Giulia Quattrocolo | Summary: Cajal-Retzius (CR) cells are a transient type of neuron that populate the postnatal hippocampus. The role of transient cell types and circuits […]
Kavli Affiliate: Jingyi Guo | Authors: Yanling xin, Qinghai He, Huilin Liang, Jingyi Guo, Qi Zhong, Ke Zhang, Jinyan Li, Yizhi Liu and Shuyi Chen | Summary: N6-methyladenosine (m6A) is the most prevalent mRNA internal modification and has been shown to regulate the development, physiology and pathology of various tissues. However, the functions of the […]
Kavli Affiliate: Edvard Moser, May Britt Moser, Ragnhild Leifsdottir, Horst Obenhaus | Authors: Soledad Gonzalo Cogno, Horst A. Obenhaus, Ragnhild Irene Jacobsen, Flavio Donato, May-Britt Moser and Edvard I. Moser | Summary: The medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity […]