Attention-like regulation of theta sweeps in the brain’s spatial navigation circuit

Kavli Affiliate: Edvard Moser and May-Britt Moser | Authors: Abraham Z. Vollan, Michael F. Schellenberger, May-Britt Moser and Edvard I. Moser | Summary: Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid– and place-cell population activity, which sample nearby space in a left-right-alternating […]


Continue.. Attention-like regulation of theta sweeps in the brain’s spatial navigation circuit

Proteomic profile of hippocampal growth cones through early postnatal development

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Giulia Quattrocolo and Maike Krause | Authors: Maike Krause, Kamilla Aase Kronberg, Paulo Jorge Bettencourt Girao, Lara Sophie Strohmeier and Giulia Quattrocolo | Summary: The early postnatal period represents a critical window for neural circuit assembly in the developing hippocampus. […]


Continue.. Proteomic profile of hippocampal growth cones through early postnatal development

Functional independence of entorhinal grid cell modules enables remapping in hippocampal place cells

Kavli Affiliate: Edvard Moser and May-Britt Moser | Authors: Christine M Lykken, Benjamin R Kanter, Anne Nagelhus, Jordan Carpenter, Matteo Guardamagna, Edvard I Moser and May-Britt Moser | Summary: A systems-level understanding of cortical computation requires insight into how neural codes are transformed across distinct brain circuits. In the mammalian cortex, one of the few […]


Continue.. Functional independence of entorhinal grid cell modules enables remapping in hippocampal place cells

Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain

Kavli Affiliate: Emre Yaksi | Authors: Anh-Tuan Trinh, Anna Maria Ostenrath, Ignacio del Castillo-Berges, Susanne Kraus, Fanchon Cachin, Bram Serneels, Koichi Kawakami and Emre Yaksi | Summary: Thalamocortical projections contribute to the spatial organization and functional hierarchies of the mammalian cortex. Primary sensory cortices receive topographically segregated information from first-order thalamic nuclei, which process distinct […]


Continue.. Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain

Long-range inhibitory axons from medial entorhinal cortex target lateral entorhinal neurons projecting to the hippocampus

Kavli Affiliate: Menno Witter | Authors: Eirik S. Nilssen, Bente Jacobsen, Thanh P. Doan, Paulo J.B. Girao and Menno P. Witter | Summary: ABSTRACT The functionally different lateral entorhinal cortex (LEC) and medial entorhinal cortex (MEC) are strongly interconnected. The role of this interconnectivity in view of their functional differences is not known. Here we […]


Continue.. Long-range inhibitory axons from medial entorhinal cortex target lateral entorhinal neurons projecting to the hippocampus

Tactile responses in the mouse perirhinal cortex show invariance to physical features of the stimulus

Kavli Affiliate: Maximiliano Jose Nigro | Rejwan Hamza Farhad Salih, Luis Fernando Cobar, Francois Philippe Pauzin, Davide Zoccolan and Maximiliano Jose Nigr | Summary: Abstract Sensory processing in the cortex follows a hierarchical structure, transforming fine-grained stimulus features into abstract, invariant representations. These transformations have typically been characterised in visual pathways ranging from primary visual […]


Continue.. Tactile responses in the mouse perirhinal cortex show invariance to physical features of the stimulus

Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Kavli Affiliate: Valentina Di Maria | Authors: Daniel P. Moore, Heather B. Steele-Stallard, Luca Pinton, Valentina Maria Lionello, Lucia Rossi, Artadokht Aghaeipour, Salma Jalal, Cherry Tsz Yan Wong, Angela Clara-Hwang, Gisèle Bonne, Peter S. Zammit and Francesco Saverio Tedesco | Summary: LMNA-related congenital muscular dystrophy (L-CMD) is amongst the most severe forms of laminopathies, which […]


Continue.. Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Clover-like object vector representations support human spatial cognition

Kavli Affiliate: Jonathan Whitlock | Authors: Marcia Becu, Ivan Markel Krasovec, Pearl Saldanha, Jonathan Whitlock and Christian F Doeller | Summary: Vector-based spatial coding has been demonstrated in rodents, yet its neural basis in humans and its contribution to navigation remain poorly understood. Using a novel spatial updating task, we show that egocentric directional signals […]


Continue.. Clover-like object vector representations support human spatial cognition

Age-related Increase in Locus Coeruleus Activity and Connectivity with Prefrontal Cortex during Ambiguity Processing

Kavli Affiliate: Maryam Ziaei | Authors: Arjun Dave, Shuer Ye, Leona R Batz, Xiaqing Lan, Heidi Jacobs and Maryam Ziaei | Summary: Interpreting ambiguous environmental cues, like facial expressions, becomes increasingly challenging with age, especially as cognitive resources decline. Managing these challenges requires adaptive neural mechanisms that are essential for maintaining mental well-being. The locus […]


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Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability

Kavli Affiliate: Maryam Ziaei | Authors: Shuer Ye, Arjun Dave, Alireza Salami and Maryam Ziaei | Summary: Functional dedifferentiation, a hallmark of brain aging particularly evident within the frontoparietal network (FPN), has been extensively investigated in the context of cognitive decline, yet its implications for late-life mental health remain poorly understood. Leveraging naturalistic fMRI combined […]


Continue.. Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability