Tactile responses in the mouse perirhinal cortex show invariance to physical features of the stimulus

Posted by dbos NTNU, This Week: Neuroscience

Kavli Affiliate: Maximiliano Jose Nigro | Rejwan Hamza Farhad Salih, Luis Fernando Cobar, Francois Philippe Pauzin, Davide Zoccolan and Maximiliano Jose Nigr | Summary: Abstract Sensory processing in the cortex follows a hierarchical structure, transforming fine-grained stimulus features into abstract, invariant representations. These transformations have typically been characterised in visual pathways ranging from primary visual […]


Continue.. Tactile responses in the mouse perirhinal cortex show invariance to physical features of the stimulus

Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Posted by dbos NTNU

Kavli Affiliate: Valentina Di Maria | Authors: Daniel P. Moore, Heather B. Steele-Stallard, Luca Pinton, Valentina Maria Lionello, Lucia Rossi, Artadokht Aghaeipour, Salma Jalal, Cherry Tsz Yan Wong, Angela Clara-Hwang, Gisèle Bonne, Peter S. Zammit and Francesco Saverio Tedesco | Summary: LMNA-related congenital muscular dystrophy (L-CMD) is amongst the most severe forms of laminopathies, which […]


Continue.. Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies

Clover-like object vector representations support human spatial cognition

Posted by dbos NTNU

Kavli Affiliate: Jonathan Whitlock | Authors: Marcia Becu, Ivan Markel Krasovec, Pearl Saldanha, Jonathan Whitlock and Christian F Doeller | Summary: Vector-based spatial coding has been demonstrated in rodents, yet its neural basis in humans and its contribution to navigation remain poorly understood. Using a novel spatial updating task, we show that egocentric directional signals […]


Continue.. Clover-like object vector representations support human spatial cognition

Age-related Increase in Locus Coeruleus Activity and Connectivity with Prefrontal Cortex during Ambiguity Processing

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Kavli Affiliate: Maryam Ziaei | Authors: Arjun Dave, Shuer Ye, Leona R Batz, Xiaqing Lan, Heidi Jacobs and Maryam Ziaei | Summary: Interpreting ambiguous environmental cues, like facial expressions, becomes increasingly challenging with age, especially as cognitive resources decline. Managing these challenges requires adaptive neural mechanisms that are essential for maintaining mental well-being. The locus […]


Continue.. Age-related Increase in Locus Coeruleus Activity and Connectivity with Prefrontal Cortex during Ambiguity Processing

Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability

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Kavli Affiliate: Maryam Ziaei | Authors: Shuer Ye, Arjun Dave, Alireza Salami and Maryam Ziaei | Summary: Functional dedifferentiation, a hallmark of brain aging particularly evident within the frontoparietal network (FPN), has been extensively investigated in the context of cognitive decline, yet its implications for late-life mental health remain poorly understood. Leveraging naturalistic fMRI combined […]


Continue.. Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability

Differences in Cajal-Retzius cell density and postnatal persistence across cortical areas revealed by a novel intersectional genetic labeling approach

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Kavli Affiliate: Giulia Quattrocolo | Authors: Kristian Moan, Robert P Machold and Giulia Quattrocolo | Summary: Cajal-Retzius (CR) cells are glutamatergic neurons that transiently populate the most superficial layer of the isocortex and allocortex during development, serving an essential role during both prenatal and early postnatal brain development. Notably, these cells disappear from most cortical […]


Continue.. Differences in Cajal-Retzius cell density and postnatal persistence across cortical areas revealed by a novel intersectional genetic labeling approach

Topographically organized dorsal raphe activity modulates forebrain sensory-motor computations and adaptive behaviors.

Posted by dbos NTNU

Kavli Affiliate: Emre Yaksi | Authors: Aytac Kadir Mutlu, Bram Serneels, Christoph Wiest, Anh-Tuan Trinh, Ricarda Bardenhewer, Fabrizio Palumbo, Oda Bjornevik Frisvold, Inger Kristine Fjeldskaar Aukrus, Anna Maria Ostenrath and Emre Yaksi | Summary: The dorsal raphe nucleus (DRN) plays an important role in shaping a wide range of behaviors, including mood, motivation, appetite, sleep, […]


Continue.. Topographically organized dorsal raphe activity modulates forebrain sensory-motor computations and adaptive behaviors.

Dorsal-caudal and ventral hippocampus target different cell populations in the medial frontal cortex in rodents

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Kavli Affiliate: Menno Witter | Authors: Paola Alemán-Andrade, Menno P. Witter, Ken-Ichiro Tsutsui and Shinya Ohara | Summary: Direct projections from the ventral hippocampus (vHPC) to the medial frontal cortex (MFC) play crucial roles in memory and emotional regulation. Using anterograde transsynaptic tracing and in vitro electrophysiology in mice, we document a previously unexplored pathway […]


Continue.. Dorsal-caudal and ventral hippocampus target different cell populations in the medial frontal cortex in rodents

Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors

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Kavli Affiliate: Emre Yaksi | Authors: Anna Maria Ostenrath, Nicholas Faturos, Yagnur Isik Ciftci Cobanoglu, Bram Serneels, Inyoung Jeong, Anja Enz, Francisca Hinrichsen, Aytac Kadir Mutlu, Ricarda Bardenhewer, Suresh Kumar Jetti, Stephan C. F. Neuhauss, Nathalie Jurisch-Yaksi and Emre Yaksi | Summary: Inhibition contributes to various brain computations from sensory motor transformations to cognitive operations. […]


Continue.. Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors

Single neurons and networks in the claustrum integrate input from widespread cortical sources

Posted by klaurent NTNU

Kavli Affiliate: Clifford Kentros, Menno Witter | Authors: Andrew M Shelton, David K Oliver, Joachim S Grimstvedt, Ivan P Lazarte, Ishaan Kapoor, Jake A Swann, Caitlin A Ashcroft, Simon N Williams, Niall Conway, Amy Robinson, Clifford G Kentros, Menno P Witter, Simon JB Butt and Adam M Packer | Summary: The claustrum is highly interconnected […]


Continue.. Single neurons and networks in the claustrum integrate input from widespread cortical sources