Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

Kavli Affiliate: Loyal Goff | Authors: Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren S Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna Leser, Mithra Kumar, Shriya Bakhshi, Matthew J Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal Goff and Pankaj Jay Pasricha | Summary: The enteric nervous system (ENS), a collection […]


Continue.. Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

Human Connectomes Are Heritable

Kavli Affiliate: Joshua Vogelstein | Authors: Jaewon Chung, Eric W Bridgeford, Michael Powell and Joshua T Vogelstein | Summary: The heritability of human connectomes is crucial for understanding the genetic and environmental factors that influence variations in connectomes, which can provide insights into behavior and disease. However, current approaches to studying connectome heritability assume an […]


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A Universal Method for Crossing Molecular and Atlas Modalities using Simplex-Based Image Varifolds and Quadratic Programming

Kavli Affiliate: Laurent Younes, Michael Miller, Jean Fan | Authors: Kaitlin M Stouffer, Alain Trouve, Laurent Younes, Michael Kunst, Lydia Ng, Hongkui Zeng, Manjari Anant, Jean Fan, Yongsoo Kim and Michael I Miller | Summary: This paper explicates a solution to the problem of building correspondences between molecular-scale transcriptomics and tissue-scale atlases. The central model […]


Continue.. A Universal Method for Crossing Molecular and Atlas Modalities using Simplex-Based Image Varifolds and Quadratic Programming

A brief real-time fNIRS-informed neurofeedback training of the prefrontal cortex changes brain activity and connectivity during subsequent working memory challenge

Kavli Affiliate: David Linden | Authors: Xi Yang, Yixu Zeng, Guojuan Jiao, Xiyang Gan, David Linden, Dennis Hernaus, Chaoze Zhu, Keshuang Li, Dezhong Yao, Shuxia Yao, Yihan Jiang and Benjamin Becker | Summary: Working memory (WM) represents a building-block of higher cognitive functions and a wide range of mental disorders are associated with WM impairments. […]


Continue.. A brief real-time fNIRS-informed neurofeedback training of the prefrontal cortex changes brain activity and connectivity during subsequent working memory challenge

Batch Effects are Causal Effects: Applications in Human Connectomics

Kavli Affiliate: Brian Caffo, Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Batch effects, undesirable sources of variance across multiple experiments, present a substantial hurdle for scientific and clinical discoveries. Specifically, the […]


Continue.. Batch Effects are Causal Effects: Applications in Human Connectomics

Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions

Kavli Affiliate: Michael Beer | Authors: Renhe Luo, Jielin Yan, Jin Woo Oh, Wang Xi, Dustin Shigaki, Wilfred Wong, Hyunwoo Cho, Dylan Murphy, Ronald Cutler, Bess P. Rosen, Julian Pulecio, Dapeng Yang, Rachel Glenn, Tingxu Chen, Qing V. Li, Thomas Vierbuchen, Simone Sidoli, Effie Apostolou, Danwei Huangfu and Michael A. Beer | Summary: Comprehensive enhancer […]


Continue.. Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions

BrainLine: An Open Pipeline for Connectivity Analysis of Heterogeneous Whole-Brain Fluorescence Volumes

Kavli Affiliate: Michael Miller, Joshua Vogelstein | Authors: Thomas Athey, Matthew Wright, Marija Pavlovic, Vikram Chandrashekhar, Karl Deisseroth, Michael Miller and Joshua Vogelstein | Summary: Whole-brain fluorescence images require several stages of computational processing to fully reveal the neuron morphology and connectivity information they contain. However, these computational tools are rarely part of an integrated […]


Continue.. BrainLine: An Open Pipeline for Connectivity Analysis of Heterogeneous Whole-Brain Fluorescence Volumes

Early retinal deprivation crossmodally alters nascent subplate circuits and activity in the auditory cortex during the precritical period

Kavli Affiliate: Patrick Kanold | Authors: Didhiti Mukherjee, Binghan Xue, Chih-Ting Chen, Minzi Chang, Joseph P-Y. Kao and Patrick O. Kanold | Summary: Sensory perturbation in one modality results in adaptive reorganization of neural pathways within the spared modalities, a phenomenon known as “crossmodal plasticity”, which has been examined during or after the classic ‘critical […]


Continue.. Early retinal deprivation crossmodally alters nascent subplate circuits and activity in the auditory cortex during the precritical period

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

Kavli Affiliate: Keri Martinowich | Authors: Louise A. Huuki-Myers, Abby Spangler, Nicholas J. Eagles, Kelsey D. Montgomery, Sang Ho Kwon, Boyi Guo, Melissa Grant-Peters, Heena R. Divecha, Madhavi Tippani, Chaichontat Sriworarat, Annie B. Nguyen, Prashanthi Ravichandran, Matthew N. Tran, Arta Seyedian, PsychENCODE Consortium, Thomas M. Hyde, Joel E. Kleinman, Alexis Battle, Stephanie C. Page, Mina […]


Continue.. Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

Mapping Neurophysiological Subtypes of Major Depressive Disorder Using Normative Models of the Functional Connectome

Kavli Affiliate: Xiaoqin Wang | Authors: Xiaoyi Sun, Jin Liu, Qing Ma, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Wenxu Wang, Yong […]


Continue.. Mapping Neurophysiological Subtypes of Major Depressive Disorder Using Normative Models of the Functional Connectome