Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants

Kavli Affiliate: Michael Miller | Authors: Mustansir Pindwarawala, Faiyaz A. K. Abid, Jaeeun Lee, Michael L. Miller, Juliet S. Noppers, Andrew P. Rideout and Melina A. Agosto | Summary: Summary: Synaptic transmission from photoreceptors to ON-bipolar cells (BCs) requires the postsynaptic metabotropic glutamate receptor mGluR6, located at BC dendritic tips. Binding of the neurotransmitter glutamate […]


Continue.. Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants

Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

Kavli Affiliate: Michael Beer | Authors: Joseph F Hoff, Kirsty E Goudar, Michael Beer, Philip Hinchliffe, John M Shaw, Catherine L Tooke, Yuiko Takebayashi, Adrian J Mulholland, Christopher J Schofield and James Spencer | Summary: Carbapenemases, β-lactamases hydrolysing carbapenem antibiotics, severely challenge treatment of multi-drug resistant bacterial infections. OXA-48 is among the most widely disseminated […]


Continue.. Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

Separating the control of moving and holding still in post-stroke arm paresis

Kavli Affiliate: Reza Shadmehr | Authors: Alkis M. Hadjiosif, Kahori Kita, Scott T. Albert, Robert A. Scheidt, Reza Shadmehr and John W. Krakauer | Summary: Moving and holding still have been posited to be under separate control regimes for both eye and arm movements. The paretic arm after stroke is notable for abnormalities both at […]


Continue.. Separating the control of moving and holding still in post-stroke arm paresis

Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan

Kavli Affiliate: Dwight Bergles and Loyal Goff | Authors: Dongeun Heo, Anya A. Kim, Björn Neumann, Valerie N. Doze, Yu Kang T Xu, Yevgeniya A. Mironova, Jared Slosberg, Loyal A. Goff, Robin J. M. Franklin and Dwight E Bergles | Summary: Oligodendrocyte progenitor cells (OPCs) are highly dynamic, widely distributed glial cells of the central […]


Continue.. Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan

Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates

Kavli Affiliate: Keri Martinowich | Authors: Michael S Totty, Rita Cervera-Juanes, Svitlana V Bach, Lamya Ben Ameur, Madeline R Valentine, Evan Simons, Mckenna D Romac, Hoa Trinh, Krystal Henderson, Ishbel Del Rosario, Madhavi Tippani, Ryan A Miller, Joel E Kleinman, Stephanie Cerceo Page, Arpiar Saunders, Thomas M Hyde, Keri Martinowich, Stephanie C Hicks and Vincent […]


Continue.. Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates

Why do bats fly into cave doors? Inattentional blindness in echolocating animals

Kavli Affiliate: Cynthia F. Moss | Authors: Nikita M Finger, Keegan E Eveland, Xiaoyan Yin and Cynthia F Moss | Summary: Echolocating bats can navigate complex 3D environments by integrating prior knowledge of spatial layouts and real-time sensory cues. This study demonstrates that inattentional blindness to sensory information undermines successful navigation in Egyptian fruit bats, […]


Continue.. Why do bats fly into cave doors? Inattentional blindness in echolocating animals

Role of dopamine in reward expectation and predictability during execution of action sequences

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Yifeng Cheng, Joanna Zhou, Haley Province, Nathalie Thiriet, Patricia H Janak and Youna Vandaele | Summary: Reward-associated cues serve different functions depending on whether they precede or terminate action sequences. Cues that precede action sequences and signal opportunity for reward could serve as GO signals to initiate […]


Continue.. Role of dopamine in reward expectation and predictability during execution of action sequences

HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s Disease

Kavli Affiliate: Michael Miller | Authors: Emmanuel C Ijezie, Michael J Miller, Celine Hardy, Ava R Jarvis, Timothy Czajka, Lianna D’Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy and David Butler | Summary: INTRODUCTION Herpes simplex virus 1 (HSV-1) infection alters critical markers of Alzheimer’s Disease (AD) in neurons. One key marker of AD is the […]


Continue.. HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s Disease

Why do we have so many excitatory neurons?

Kavli Affiliate: Carey Priebe and Joshua Vogelstein | Authors: Qingyang Wang, Albert Cardona, Marta Zlatic, Joshua Vogelstein and Carey Priebe | Summary: Approximately four in five neurons are excitatory. This is true across functional regions and species. Why do we have so many excitatory neurons? Little is known. Here we provide a normative answer to […]


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Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns in Breast Multiplexed Digital Pathology

Kavli Affiliate: Jeremias Sulam | Authors: Zhenzhen Wang, Cesar A. Santa-Maria, Aleksander S. Popel and Jeremias Sulam | Summary: The tumor microenvironment is widely recognized for its central role in driving cancer progression and influencing prognostic outcomes. There have been increasing efforts dedicated to characterizing this complex and heterogeneous environment, including developing potential prognostic tools […]


Continue.. Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns in Breast Multiplexed Digital Pathology