Hyper-migratory CAR T cells alleviate ovarian cancer metastatic burden and improve prognosis

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Praful R Nair, Eban Hanna, Saurabh Joshi, Victoria Duarte Alvarado, Challice Bonifant and Denis Wirtz | Summary: Cellular immunotherapy has shown remarkable efficacy in hematological malignancies but remains limited by infiltration issues in solid tumors, leading to poor treatment efficacy. We have recently shown that mesothelin-targeting CAR T cells […]


Continue.. Hyper-migratory CAR T cells alleviate ovarian cancer metastatic burden and improve prognosis

Ptbp1 is not required for retinal neurogenesis and cell fate specification.

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Haley Appel, Rogger Carmen-Orozco, Clayton Santiago, Thanh Hoang and Seth Blackshaw | Summary: The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes […]


Continue.. Ptbp1 is not required for retinal neurogenesis and cell fate specification.

Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Jingliang Simon Zhang, Brian Guy, Clayton P Santiago, Caterina Tiozzo, Meghana Sreenath, Ya-Wen Chen, Seth Blackshaw and Robert J Johnston, Jr | Summary: Retinal ganglion cells (RGCs) are the projection neurons that transmit visual information from the retina to the brain. In many species, a substantial proportion of RGCs […]


Continue.. Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids

Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)

Posted by dbos Hopkins

Kavli Affiliate: Alexander Szalay | Authors: Tricia R Cottrell, Jeffrey S Roskes, Michael Fotheringham, Emily Cohen, Boyang Zhang, Logan L Engle, Daphne Wang, Elizabeth Will, Joel C Sunshine, Daniel Jimenez-Sanchez, Zhen Zheng, Justina X Caushi, Jiajia Zhang, Nina D’Amiano, Julie Stein-Deutsch, Sonali Uttam, Katie Pirie, Darah Vlaminck, Michelle Mataj, Alexa Fiorante, Nicole Espinosa, Teodora Popa, […]


Continue.. Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Prashanthi Ravichandran, Svitlana V. Bach, Robert A. Phillips III, Madeline R. Valentine, Nicholas J. Eagles, Yufeng Du, Ishbel Del Rosario, Ryan A. Miller, Heena R. Divecha, Madhavi Tippani, Kelsey D. Montgomery, Joel E. Kleinman, Shizhong Han, Stephanie Cerceo Page III, Thomas M. Hyde, Leonardo Collado Torres, Alexis Battle, Keri […]


Continue.. Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens

Exploring endothelial cell environments across organs in spatially resolved omics data

Posted by dbos Hopkins

Kavli Affiliate: Jean Fan | Authors: Yashvardhan Jain, Jodie Jepson, Roy Chen, Elizabeth Maier, Bruce W. Herr II, Aleix Puig-Barbe, Ellen M. Quardokus, Danial Qaurooni, Clarence Yapp, Samuel L. Ewing, Archibald Enninful, Negin Farzad, Andreas Bueckle, Quinn T. Easter, Bruno Matuck, Chenchen Zhu, Emma Marie Monte, Jeffrey M. Purkerson, Matthew Jehrio, Ravi S. Misra, Rong […]


Continue.. Exploring endothelial cell environments across organs in spatially resolved omics data

A neural network model of free recall learns multiple memory strategies

Posted by dbos Hopkins, UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Moufan Li, Kristpher T. Jensen, Qiong Zhang, Qihong Lu and Marcelo G. Mattar | Summary: Humans exhibit structured patterns of memory recall, including a tendency to recall more recent information and to recall events in the same order they were experienced. Classic computational models explain these patterns by positing […]


Continue.. A neural network model of free recall learns multiple memory strategies

Toward navigating emotional states using real-time representational similarity analysis fMRI neurofeedback – a feasibility study

Posted by dbos Hopkins

Kavli Affiliate: David Linden | Authors: Xuelei Wang, Assunta Ciarlo, Michael Luehrs, Alexander Atanasyan, David Böken, Jürgen Roßmann, Michael Schluse, Maren Jäger, Marisa Nordt, Fengyu Cong, Klaus Mathiak, David Linden, Rainer Goebel, David MA Mehler and Jana Zweerings | Summary: Real-time functional magnetic resonance imaging neurofeedback (rt-fMRI-NF) is a promising non-invasive brain-computer-interface (BCI) technique for […]


Continue.. Toward navigating emotional states using real-time representational similarity analysis fMRI neurofeedback – a feasibility study

JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish.

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Leah J Elias, Harrison Khoo, Francois Kroll, Caroline Zhang, Soojung C Hur, Jason Rihel and Seth Blackshaw | Summary: While sleep deprivation broadly disrupts health and well-being, the neural and molecular mechanisms that signal increased sleep pressure remain poorly understood. A key obstacle to progress is the fact that […]


Continue.. JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish.

3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Vasco Queiroga, Yajuan Li, Alfredo Hernandez, Ashleigh Crawford, Xiaoyu Qin, Mei Zhong, Margarita Tsapatsis, Saurabh Joshi, Donald Kramer, Oliver Nizet, Habin Bea, Yuhan Li, Shuo Qin, Robert O Flynn, Mingder Yang, Britanny Pratt, Fan Wu, Paul Gensbigler, Max Blecher, Pei-Hsun Wu, Luciane Tsukamoto Kagohara, Ie Ming Shih, […]


Continue.. 3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors