Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Sarah Holden, Julie Borovicka, Jacob Icardi, Davina Patel, Rushik Patel, Jacob Raber and Hod Dana | Summary: To date, recording of cellular-resolution activity from awake mice has required either head fixation under a microscope or attaching a miniaturized device to the skull, both of which inevitably affect […]
Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Christian Amlang, Chi-Ying Lin, Leila Montaser-Kouhsari, Natasha Desai, Ming-Kai Pan, Sheng-Han Kuo and Daphna Shohamy | Summary: Recent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to […]
Kavli Affiliate: Kenneth Miller | Authors: Serena Di santo, Mario Dipoppa, Andreas Keller, Morgane Roth, Massimo Scanziani and Kenneth D Miller | Summary: Neural responses to a localized visual stimulus are modulated by the content of its surrounding. This phenomenon manifests in several forms of contextual modulation, including three interrelated properties of the visual cortex: […]
Kavli Affiliate: Larry Abbott | Authors: Ching Fang, Dmitriy Aronov, Larry F Abbott and Emily Mackevicius | Summary: The predictive nature of the hippocampus is thought to be useful for memory-guided cognitive behaviors. Inspired by the reinforcement learning literature, this notion has been formalized as a predictive map called the successor representation (SR). The SR […]
Kavli Affiliate: Liam Paninski | Authors: The International Brain Laboratory, Kush Banga, Julius Benson, Niccolò Bonacchi, Sebastian A Bruijns, Rob Campbell, Gaëlle A Chapuis, Anne K Churchland, M Felicia Davatolhagh, Hyun Dong Lee, Mayo Faulkner, Fei Hu, Julia Hunterberg, Anup Khanal, Christopher Krasniak, Guido T Meijer, Nathaniel J Miska, Zeinab Mohammadi, Jean-Paul Noel, Liam Paninski, […]
Kavli Affiliate: Stefano Fusi | Authors: W. Jeffrey Johnston and Stefano Fusi | Summary: Humans and other animals demonstrate a remarkable ability to generalize knowledge across distinct contexts and objects during natural behavior. We posit that this ability to generalize arises from a specific representational geometry, that we call abstract and that is referred to […]
Kavli Affiliate: Michael Shadlen | Authors: Gabriel M Stine, Eric M Trautmann, Danique Jeurissen and Michael N Shadlen | Summary: The brain makes decisions by accumulating evidence until there is enough to stop and choose. Neural mechanisms of evidence accumulation are well established in association cortex, but the site and mechanism of termination is unknown. […]
Kavli Affiliate: Wei Min | Authors: Daniel J.M. Crouch, Jamie R.J. Inshaw, Catherine C. Robertson, Jia-Yuan Zhang, Wei-Min Chen, Suna Onengut-Gumuscu, Antony J. Cutler, Carlo Sidore, Francesco Cucca, Flemming Pociot, Patrick Concannon, Steven S. Rich and John A. Todd | Summary: For polygenic traits, associations with genetic variants can be detected over many chromosome regions, […]
Kavli Affiliate: Ann McDermott | Authors: Kelsey M McCoy and Ann E McDermott | Summary: FtsZ filaments are the major structural component of the bacterial Z-ring and are drivers of bacterial division. While crystal structures for FtsZ from some gram positive bacteria in the presence of GTP-analog like compounds suggest the possibility of a high […]
Kavli Affiliate: Mark Churchland, Michael Shadlen | Authors: Najja J. Marshall, Joshua I. Glaser, Eric M. Trautmann, Elom A. Amematsro, Sean M. Perkins, Michael N. Shadlen, L. F. Abbott, John P. Cunningham and Mark M. Churchland | Summary: Voluntary movement requires communication from cortex to the spinal cord, where a dedicated pool of motor units […]