Kavli Affiliate: Vincent Ferrera | Authors: Dong Liu, Fabian A Munoz Silva, Soroosh Sanatkhani, Antonios Pouliopoulos, Elisa Konofagou, Jack Grinband and Vincent P. Ferrera | Summary: Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. Focused ultrasound combined with microbubbles can temporarily open the […]

Kavli Affiliate: Stefano Fusi | Authors: Lara M. Boyle, Lorenzo Posani, Sarah Irfan, Steven A. Siegelbaum and Stefano Fusi | Summary: Social recognition consists of multiple memory processes, including the detection of familiarity – the ability to rapidly distinguish familiar from novel individuals – and recollection – the effortful recall of where a social episode […]

Kavli Affiliate: Elizabeth Hillman | Authors: Dena Goldblatt, Stephanie Huang, Marie R. Greaney, Kyla R. Hamling, Venkatakaushik Voleti, Citlali Perez-Campos, Kripa B. Patel, Wenze Li, Elizabeth M. C. Hillman, Martha W. Bagnall and David Schoppik | Summary: Abstract Across the nervous system, neurons with similar attributes are topographically organized. This topography reflects developmental pressures. Oddly, […]

Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Debojyoti Das, Arundhati Das and Amaresh Chandra Panda | Summary: Current RNA purification methods widely use silica-based columns that allow quick isolation of high-quality and good quantities of RNA. However, the major limitations include high cost, the requirement of different kits for small RNA isolation, genomic DNA […]

Kavli Affiliate: Scott Small | Authors: Scott T. Small, Carlo Costantini, N’Fale Sagnon, Moussa W. Guelbeogo, Scott J. Emrich, Andrew D. Kern, Michael C. Fontaine and Nora J. Besansky | Summary: Species distributed across heterogeneous environments often evolve locally adapted ecotypes, but understanding of the genetic mechanisms involved in their formation and maintenance in the […]

Kavli Affiliate: Scott Small | Authors: Scott T Small, Carlo Costantini, N’Fale Sagnon, Moussa W Guelbeogo, Scott J Emrich, Andrew D Kern, Michael C Fontaine and Nora J Besansky | Summary: Abstract Local adaptation results in the formation of ecotypes–conspecific groups with heritable differences that increase fitness to distinct environments. The adaptive significance of ecotypes […]

Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Keith Fritzsching, Rivkah Rogawski, Yunyao Xu and Ann E McDermott | Summary: While low temperature NMR holds great promise for the analysis of unstable samples and for sensitizing NMR detection, spectral broadening in frozen protein samples is a common experimental challenge. One hypothesis explaining the additional linewidth […]

Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Lichirui Zhang, Richard Friesner and Ann E McDermott | Summary: NMR chemical shifts provide a sensitive probe of protein structure and dynamics. Prediction of shifts, and therefore interpretation of shifts, particularly for the frequently measured amidic 15N sites, remains a tall challenge. We demonstrate that protein 15N […]

Kavli Affiliate: Ann McDermott | Authors: Yizhuo Yang, Keith Fritzsching, Sasha He and Ann E McDermott | Summary: T-Cell Intracellular Antigen-1 (TIA1) is a 43 kDa multi-domain RNA-binding protein involved in stress granule formation during eukaryotic stress response, and has been implicated in neurodegenerative diseases including Welander distal myopathy and amyotrophic lateral sclerosis. TIA1 contains […]

Kavli Affiliate: Kenneth Miller | Authors: Agostina Palmigiano, Francesco Fumarola, Daniel P. Mossing, Nataliya Kraynyukova, Hillel Adesnik and Kenneth Miller | Summary: The visual cortex receives non-sensory inputs containing behavioral and brain state information. Here we propose a parallel between optogenetic and behavioral modulations of activity and characterize their impact on cell-type-specific V1 processing under […]