Brain-wide representations of prior information in mouse decision-making

Kavli Affiliate: Liam Paninski | Authors: Charles Findling, Felix Hubert, International Brain Laboratory, Luigi Acerbi, Brandon Benson, Julius Benson, Daniel Birman, Niccolò Bonacchi, Matteo Carandini, Joana A Catarino, Gaelle A Chapuis, Anne K Churchland, Yang Dan, Eric EJ DeWitt, Tatiana A Engel, Michele Fabbri, Mayo Faulkner, Ila Rani Fiete, Laura Freitas-Silva, Berk Gerçek, Kenneth D […]


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Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

Kavli Affiliate: Eric D. Siggia | Authors: Stefano Fusi and Liam Paninski | Summary: The brain is highly structured both at anatomical and functional levels. However, within individual brain areas, neurons often exhibit very diverse and seemingly disorganized responses. A more careful analysis shows that these neurons can sometimes be grouped together into specialized subpopulations […]


Continue.. Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction

Kavli Affiliate: Ann McDermott | Authors: Cassandra A Chartier, Virgil A Woods, Yunyao Xu, Anne E van Vlimmeren, Marko Jovanovic, Ann E McDermott, Daniel A Keedy and Neel H Shah | Summary: The rapid identification of protein-protein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and proximity-labeling proteomics. […]


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Cephalopod Sex Determination and its Ancient Evolutionary Origin

Kavli Affiliate: Scott Small | Authors: Gabrielle C. Coffing, Silas Tittes, Scott T. Small, Jeremea O. Songco-Casey, Denise M. Piscopo, Judit R. Pungor, Adam C Miller, Cristopher Niell and Andrew D. Kern | Summary: Octopuses, squids, and cuttlefishes – the coleoid cephalopods – are a remarkable branch in the tree of life whose members exhibit […]


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Recurrent Connectivity Shapes Spatial Coding in Hippocampal CA3 Subregions

Kavli Affiliate: Darcy Peterka and Attila Losonczy | Authors: Eunji Kong, Erfan Zabeh, Zhenrui Liao, Tiberiu S. Mihaila, Darcy S. Peterka, Caroline Wilson, Charan Santhirasegaran, Attila Losonczy and Tristan Geiller | Summary: Stable and flexible neural representations of space in the hippocampus are crucial for navigating complex environments. However, how these distinct representations emerge from […]


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In vivo cell-type and brain region classification via multimodal contrastive learning

Kavli Affiliate: Liam Paninski | Authors: Han Yu, Hanrui Lyu, Ethan YiXun Xu, Charlie Windolf, Eric Kenji Lee, Fan Yang, Andrew M Shelton, Shawn Olsen, Sahar Minavi, Olivier Winter, The International Brain Laboratory, Eva L Dyer, Chandramouli Chandrasekaran, Nicholas A Steinmetz, Liam Paninski and Cole Hurwitz | Summary: Current electrophysiological approaches can track the activity […]


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Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

Kavli Affiliate: Michael Beer | Authors: Joseph F Hoff, Kirsty E Goudar, Michael Beer, Philip Hinchliffe, John M Shaw, Catherine L Tooke, Yuiko Takebayashi, Adrian J Mulholland, Christopher J Schofield and James Spencer | Summary: Carbapenemases, β-lactamases hydrolysing carbapenem antibiotics, severely challenge treatment of multi-drug resistant bacterial infections. OXA-48 is among the most widely disseminated […]


Continue.. Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

behaviorMate: An Intranet of Things Approach for Adaptable Control of Behavioral and Navigation-Based Experiments

Kavli Affiliate: Attila Losonczy | Authors: Kyu Sang Han, Inbal B Sander, Jacqueline Kumer, Eric Preston Resnick, Clare Booth, Bartholomew Starich, Jeremy Walston, Ashley L Kiemen, Sashank Reddy, Corrine Joshu, Joel Sunshine, Denis Wirtz and Pei-Hsun Wu | Summary: Investigators conducting behavioral experiments often need precise control over the timing of the delivery of stimuli […]


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Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

Kavli Affiliate: Mark Ellisman | Authors: Song-Yi Lee, Heegwang Roh, David Gonzalez-Perez, Mason R Mackey, Keun-Young Kim, Daniel Hoces, Colleen McLaughlin, Stephen R Adams, Khanh Nguyen, David J Luginbuhl, Liqun Luo, Namrata Udeshi, Steven A Carr, Rogelio A Hernandez-Lopez, Mark Ellisman, Miguel Alcalde and Alice Y Ting | Summary: Enzymes that oxidize aromatic substrates have […]


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A circuit model for transsaccadic space updating and mislocalization

Kavli Affiliate: Michael Goldberg | Authors: Xiao Wang, Sophia Tsien, Michael E. Goldberg, Mingsha Zhang and Ning Qian | Summary: We perceive a stable, continuous world despite drastic changes of retinal images across saccades. However, while persistent objects in daily life appear stable across saccades, stimuli flashed around saccades can be grossly mislocalized. We address […]


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