Dopamine release effects on striatal blood oxygenation and whole brain plasticity underlying associative learning

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Darcy Peterka | Authors: Amir Lawen, Isabella K Succi, Daniela Lichtman, Darcy S Peterka, Ishmail J Abdus-Saboor and Itamar Kahn | Summary: Dopaminergic signaling in the nucleus accumbens (NAc) is central to reward-based learning, but its relationship to brain-wide hemodynamics remains unclear. Using concurrent fMRI and dopamine photometry in awake, behaving mice, we […]


Continue.. Dopamine release effects on striatal blood oxygenation and whole brain plasticity underlying associative learning

Blood-tumor barrier organoids recapitulate glioblastoma microenvironment and enable high-throughput modeling of therapeutic delivery

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Wei Min | Authors: Pei Zhuang, Benjamin Scott, Shuai Gao, Wei-Min Meng, Rui Yin, Xinyu Nie, Ludovica Gaiaschi, Sean E Lawler, Martine LM Lamfers, Fengfeng Bei and Choi-Fong Cho | Summary: The blood-brain barrier (BBB) is a highly specialized system that is critical for regulating transport between the blood and the central nervous […]


Continue.. Blood-tumor barrier organoids recapitulate glioblastoma microenvironment and enable high-throughput modeling of therapeutic delivery

Connectome analysis of a cerebellum-like circuit for sensory prediction

Posted by dbos Columbia

Kavli Affiliate: Nathaniel Sawtell | Authors: Krista E Perks, Mariela D Petkova, Salomon Z Muller, Michael Genecin, Adishree Ghatare, Richard Schalek, Yuelong Wu, Michal Januszewski, Viren Jain, Jeff W Lichtman, LF Abbott and Nathaniel B Sawtell | Summary: Transitive inference (TI) is a cognitive process in which decisions are guided by internal representations of abstract […]


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Learning decouples accuracy and reaction time for rapid decisions in a transitive inference task

Posted by dbos Columbia

Kavli Affiliate: Vincent Ferrera | Authors: Fabian A Munoz Silva, Greg Jensen, Maxwell Shinn, Yelda Alkan, John Murray, Herbert Terrace and Vincent P Ferrera | Summary: Transitive inference (TI) is a cognitive process in which decisions are guided by internal representations of abstract relationships. While the mechanisms underlying transitive learning have been well studied, the […]


Continue.. Learning decouples accuracy and reaction time for rapid decisions in a transitive inference task

Humans share acoustic preferences with other animals

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Kavli Affiliate: Sarah Woolley | Authors: Logan S James, Sarah C Woolley, Jon T Sakata, Courtney B Hilton, Michael J Ryan and Samuel A Mehr | Summary: Many animals produce sounds during courtship, and receivers prefer some sounds over others. Shared ancestry and convergent evolution may generate similarities in preference across species and could underlie […]


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Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model

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Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Kenneth D Miller and Agostina Palmigiano | Summary: What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of […]


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WITHDRAWN: CEBPB as a potential biomarker for prognosis and immuneinfiltration in clear cell renal cell carcinoma

Posted by dbos Columbia

Kavli Affiliate: Wei Min | Authors: Yaoqiang Ren, Baoping Qiao, Min Wei, Quanfa Tian and Wenke Guo | Summary: The authors have withdrawn this manuscript because [an error in the figures or improper use of them]. Therefore, the authors do not wish this work to be cited as reference for the project. If you have […]


Continue.. WITHDRAWN: CEBPB as a potential biomarker for prognosis and immuneinfiltration in clear cell renal cell carcinoma

Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons

Posted by dbos Columbia

Kavli Affiliate: Darcy Peterka | Authors: Eddy Albarran, Akira Fushiki, Anders Nelson, David Ng, Corryn Chaimowitz, Laudan Nikoobakht, Tanya Sippy, Darcy S Peterka and Rui M Costa | Summary: The basal ganglia and midbrain dopaminergic systems are critical for motor control, reward processing, and reinforcement learning, with dysfunction in these systems implicated in numerous neurodegenerative […]


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Credit Assignment via Behavioral Timescale Synaptic Plasticity: Theoretical Frameworks

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Kavli Affiliate: Rui Costa | Authors: Ian Cone, Claudia Clopath and Rui Ponte Costa | Summary: Behavioral Timescale Synaptic Plasticity (BTSP) is a form of synaptic plasticity in which dendritic Ca2+ plateau potentials in hippocampal pyramidal neurons drive rapid place field formation. Unlike traditional learning rules, BTSP learns correlations on the timescales of seconds and […]


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The selective dynamics of interruptions at short tandem repeats

Posted by dbos Columbia

Kavli Affiliate: Michael Goldberg | Authors: Michael E Goldberg, Harriet Dashnow, Kelley Harris and Aaron R Quinlan | Summary: Short tandem repeats (STRs) are hotspots of genomic instability that mutate at rates orders of magnitude greater than non-repetitive loci due to frequent replication slippage. Expansions at some STR loci cause Mendelian diseases, while variation at […]


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