The effects of task similarity during representation learning in brains and neural networks

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Stefano Fusi | Authors: Nicholas Menghi, William Jeffrey Johnston, Simone Vigano’, Max Andreas Bosse Hinrichs, Burkhard Maess, Stefano Fusi and Christian F Doeller | Summary: The complexity of our environment poses significant challenges for adaptive behavior. Recognizing shared structures across tasks can theoretically improve learning through generalization. However, how such shared representations emerge […]


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Experience-dependent reorganization of inhibitory neuron synaptic connectivity

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Richard Axel | Authors: Andrew Jacob Pixley Fink, Samuel Muscinelli, Shuqi Wang, Marcus I Hogan, Daniel Fine English, Richard Axel, Ashok Litwin-Kumar and Carl E. Schoonover | Summary: Organisms continually tune their perceptual systems to the features they encounter in their environment1–3. We have studied how ongoing experience reorganizes the synaptic connectivity of […]


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Distinct roles of cortical layer 5 subtypes in associative learning

Posted by dbos Columbia

Kavli Affiliate: Rui Costa | Authors: Sara Moberg, Michele Garibbo, Camille Mazo, Ariel Gilad, Dietmar Schmitz, Rui Ponte Costa, Matthew E Larkum and Naoya Takahashi | Summary: Adaptive behavior is critically dependent on associative learning, where environmental cues are linked with subsequent positive or negative outcomes. In mammals, primary neocortical sensory areas serve as pivotal […]


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A Brain-Wide Map of Neural Activity during Complex Behaviour

Posted by dbos Columbia

Kavli Affiliate: Liam Paninski | Authors: International Brain Lab, Brandon Benson, Julius Benson, Daniel Birman, Niccolo Bonacchi, Matteo Carandini, Joana A Catarino, Gaelle A Chapuis, Anne K Churchland, Yang Dan, Peter Dayan, Eric EJ DeWitt, Tatiana A Engel, Michele Fabbri, Mayo Faulkner, Ila Rani Fiete, Charles Findling, Laura Freitas-Silva, Berk Gercek, Kenneth D Harris, Michael […]


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Proactive and reactive construction of memory-based preferences

Posted by dbos Columbia

Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Nathaniel D. Daw and Daphna Shohamy | Summary: We are often faced with decisions we have never encountered before, requiring us to infer possible outcomes before making a choice. Computational theories suggest that one way to make these types of decisions is by accessing and linking related […]


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Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

Posted by dbos Columbia

Kavli Affiliate: Liam Paninski | Authors: Stefano Fusi and Liam Paninski | Summary: The brain is highly structured both at anatomical and functional levels. However, within individual brain areas, neurons often exhibit very diverse and seemingly disorganized responses. A more careful analysis shows that these neurons can sometimes be grouped together into specialized subpopulations (categorical […]


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Brain-wide representations of prior information in mouse decision-making

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski | Authors: Charles Findling, Felix Hubert, International Brain Laboratory, Luigi Acerbi, Brandon Benson, Julius Benson, Daniel Birman, Niccolò Bonacchi, Matteo Carandini, Joana A Catarino, Gaelle A Chapuis, Anne K Churchland, Yang Dan, Eric EJ DeWitt, Tatiana A Engel, Michele Fabbri, Mayo Faulkner, Ila Rani Fiete, Laura Freitas-Silva, Berk Gerçek, Kenneth D […]


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Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction

Posted by dbos Columbia

Kavli Affiliate: Ann McDermott | Authors: Cassandra A Chartier, Virgil A Woods, Yunyao Xu, Anne E van Vlimmeren, Marko Jovanovic, Ann E McDermott, Daniel A Keedy and Neel H Shah | Summary: The rapid identification of protein-protein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and proximity-labeling proteomics. […]


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Cephalopod Sex Determination and its Ancient Evolutionary Origin

Posted by dbos Columbia

Kavli Affiliate: Scott Small | Authors: Gabrielle C. Coffing, Silas Tittes, Scott T. Small, Jeremea O. Songco-Casey, Denise M. Piscopo, Judit R. Pungor, Adam C Miller, Cristopher Niell and Andrew D. Kern | Summary: Octopuses, squids, and cuttlefishes – the coleoid cephalopods – are a remarkable branch in the tree of life whose members exhibit […]


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Recurrent Connectivity Shapes Spatial Coding in Hippocampal CA3 Subregions

Posted by dbos Columbia

Kavli Affiliate: Darcy Peterka and Attila Losonczy | Authors: Eunji Kong, Erfan Zabeh, Zhenrui Liao, Tiberiu S. Mihaila, Darcy S. Peterka, Caroline Wilson, Charan Santhirasegaran, Attila Losonczy and Tristan Geiller | Summary: Stable and flexible neural representations of space in the hippocampus are crucial for navigating complex environments. However, how these distinct representations emerge from […]


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