A polymeric, PDMS-based large-scale skull replacement suitable for optical and mechanical access for long-term neuronal imaging, electrophysiology, and optogenetics

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Rafael Yuste | Authors: Kengo Takahashi, Gerhardus Jan Huis in ‘t Veld, Davide Benedetti, Jun-Ying Wang, Samuel Pontes Quero, Rafael Yuste, Cyriel M.A. Pennartz and Umberto Olcese | Summary: Many techniques to record and manipulate neuronal activity across large portions of the vertebrate brain, such as widefield and two-photon calcium imaging, electrophysiology, and […]


Continue.. A polymeric, PDMS-based large-scale skull replacement suitable for optical and mechanical access for long-term neuronal imaging, electrophysiology, and optogenetics

Hippocampus facilitates reinforcement learning under partial observability

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Rui Costa | Authors: Dabal Pedamonti, Samia Mohinta, Martin Dimitrov, Hugo Malagon-Vina, Stephane Ciocchi and Rui Ponte Costa | Summary: Mastering navigation in environments with limited visibility is crucial for survival. Although the hippocam-pus has been associated with goal-oriented navigation, its role in real-world behaviour remains unclear. To investigate this, we combined deep […]


Continue.. Hippocampus facilitates reinforcement learning under partial observability

In vivo cell-type and brain region classification via multimodal contrastive learning

Posted by dbos Columbia

Kavli Affiliate: Liam Paninski | Authors: Han Yu, Hanrui Lyu, Ethan YiXun Xu, Charlie Windolf, Eric Kenji Lee, Fan Yang, Andrew M Shelton, Shawn Olsen, Sahar Minavi, Olivier Winter, The International Brain Laboratory, Eva L Dyer, Chandramouli Chandrasekaran, Nicholas A Steinmetz, Liam Paninski and Cole Hurwitz | Summary: Current electrophysiological approaches can track the activity […]


Continue.. In vivo cell-type and brain region classification via multimodal contrastive learning

Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

Posted by klaurent Columbia

Kavli Affiliate: Attila Losonczy | Authors: Stephanie A Herrlinger, Jiayao Wang, Bovey Y Rao, Jonathan Chang, Joseph Gogos, Attila Losonczy and Dennis Vitkup | Summary: Neuropsychiatric disorders such as autism spectrum disorder (ASD) and schizophrenia (SCZ) share genetic risk factors, including rare high penetrance single nucleotide variants and copy number variants (CNVs), and exhibit both […]


Continue.. Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

Posted by klaurent Columbia

Kavli Affiliate: Ann McDermott | Authors: Chengming He, Nikhil R Varghese, Eric G Keeler, Chi L L Pham, Brayden Williams, Stephan Tetter, Crystal Semaan, Karyn L Wilde, Simon H J Brown, James C Bouwer, Yann Gambin, Emma Sierecki, Megan Steain, Margaret Sunde and Ann E McDermott | Summary: The formation of RIP-homotypic interaction motif (RHIM)-based […]


Continue.. Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

Deficiency of mitophagy mediator Parkin in aortic smooth muscle cells exacerbates abdominal aortic aneurysm

Posted by dbos Columbia

Kavli Affiliate: Robert Hawkins | Authors: Hui Wang, Matthew Kazaleh, Rachel A. Gioscia-Ryan, Jessica Millar, Gerard Temprano-Sagrera, Sherri Wood, Fran Van Den Burgh, Muriel G Blin, Kathleen M Wragg, Adrain Luna, Robert Bruce Hawkins, Scott A Soleimanpour, Maria Sabater-Lleal, Chang Shu, Daniel A Beard, Gorav Ailawadi, Jane C Deng, Daniel R Goldstein and Morgan Salmon […]


Continue.. Deficiency of mitophagy mediator Parkin in aortic smooth muscle cells exacerbates abdominal aortic aneurysm

Accessible, realistic genome simulation with selection using stdpopsim

Posted by dbos Columbia

Kavli Affiliate: Scott Small | Authors: Graham Gower, Nathaniel S. Pope, Murillo F. Rodrigues, Silas Tittes, Linh N. Tran, Ornob Alam, Maria Izabel Alves Cavassim, Peter D. Fields, Benjamin C. Haller, Xin Huang, Ben Jeffrey, Kevin Korfmann, Christopher C. Kyriazis, Jiseon Min, Ines Rebollo, Clara T Rehmann, Scott T. Small, Christopher C. R. Smith, Georgia […]


Continue.. Accessible, realistic genome simulation with selection using stdpopsim

Distinct representations of an anxiogenic environment in different cell types of the ventral hippocampus

Posted by dbos Columbia

Kavli Affiliate: Stefano Fusi and René Hen | Authors: Jack E Berry, Jessica C Jimenez, Wei-Li Chang, Kenechukwu Michael Ogbu, Nicholas Manfred, Karly Tegang, Stefano Fusi, René Hen and Clay Lacefield | Summary: In addition to its role in episodic memory and spatial navigation, the hippocampus has also been found to influence mood-related disorders such […]


Continue.. Distinct representations of an anxiogenic environment in different cell types of the ventral hippocampus

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primates

Posted by dbos Columbia

Kavli Affiliate: Vincent Ferrera | Authors: Alec J. Batts, Robin Ji, Sua Bae, Fotios N. Tsitsos, Sergio Jiménez-Gambín, Nancy Kwon, Samantha L. Gorman, Deny Tsakri, Rebecca L. Noel, Jonas Bendig, Daniella A. Jimenez, Melody DiBenedetto, Sofia A. Del Castillo, Filimon B. Keleta, James Caicedo, Alexander Romanov, Colleen T. Curley, Yulia Dzhashiashvili, Greglynn D. Walton-Gibbs, Bradley […]


Continue.. Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primates

An evolutionarily conserved role for separase in the regulation of nuclear lamins

Posted by dbos Columbia

Kavli Affiliate: Michael Goldberg | Authors: Francesca Cipressa, Gaelle Pennarun, Giuseppe Bosso, Serena Rosignoli, Liliana Tullo, Nadia Schiralli, Chiara Borghi, Alessandro Paiardini, Michael L Goldberg, Pascale Bertrand and Giovanni Cenci | Summary: Separase is a well conserved endopeptidase that facilitates sister chromatid separation at the metaphase-anaphase transition by cleaving cohesins. Beyond its role in chromosome […]


Continue.. An evolutionarily conserved role for separase in the regulation of nuclear lamins