Kavli Affiliate: Wei Min | Authors: Wei-Min Chen, Ani Manichaikul, Suna Onengut-Gumuscu, Bradford B Worrall and Stephen S Rich | Summary: Rationale A polygenic score (PGS) summarizes a person’s genetic information in a single number for a trait, and its utility in genomic medicine is well-recognized. Although PGS models have been generated for many traits, […]
Kavli Affiliate: Michael Shadlen | Authors: Lindsey S Brown, NaYoung So, L F Abbott, Michael N Shadlen and Mark S Goldman | Summary: Making accurate decisions requires the brain to maintain evolving representations of accumulated evidence. The population that maintains this evolving representation may change over the course of evidence accumulation. For example, intervening actions […]
Kavli Affiliate: Vincent Ferrera and Jacqueline Gottlieb | Authors: Yuhao Jin, Greg Jensen, Vincent Ferrera and Jacqueline Gottlieb | Summary: In natural environments, associations that indicate true learnable regularities are intermixed with those that arise from random and ultimately unlearnable relationships between events. To efficiently allocate cognitive resources and avoid inferring spurious patterns, organisms must […]
Kavli Affiliate: Stefano Fusi | Authors: Nicholas Menghi, Simone Vigano’, William Jeffrey Johnston, Salma Elnagar, Stefano Fusi and Christian F Doeller | Summary: Learning depends not only on the content of what we learn, but also on how we learn and on how experiences are structured over time. To investigate how task similarity and training […]
Kavli Affiliate: Rui Costa | Authors: Tanya Sippy, Jan L. Klee, Sulekh Fernando-Peiris, Sahil Suresh, Ines Rodrigues-Vaz, Rui M. Costa and Vivek R. Athalye | Summary: Animals can flexibly initiate actions guided by external cues or by internal drive. Disease states often disrupt cue-driven and self-paced actions in distinct ways, underscoring separable neural mechanisms. Such […]
Kavli Affiliate: Elizabeth Hillman | Authors: Mary Claire Tuohy, Ping-Chang Kuo, Adrian Chelminski, Eti Muharremi, Claudia DeSantis, Aomeng Cui, Alicia Russo, Danny Jamoul, Elizabeth Hillman, John F Crary, Jui-Hung Jimmy Yen and Dritan Agalliu | Summary: Vascular normalization [stabilization of aberrant angiogenesis and restoration of blood-brain barrier (BBB)] is critical for reducing long-term secondary sequelae […]
Kavli Affiliate: Darcy Peterka and Michael Shadlen | Authors: Jia Shen, Nuttida Rungratsameetaweemana, Prayshita Sharma, Darcy S. Peterka, Herbert Zheng Wu and Michael N. Shadlen | Summary: Cognitive operations often require flexible implementation of stimulus–response contingencies, depending on context. We developed an olfactory task in which mice learned to associate a test odor with a […]
Kavli Affiliate: Rafael Yuste | Authors: Jason Ken Adhinarta, Yutian Fan, Adam Gohain, Michael Lin, Paige Nurkin, Richard Ren, Micaela Roth, Shulin Zhang, Ayal Yakobe, Rafael Yuste and Donglai Wei | Summary: Vesicles are critical components of neurons that package neurotransmitters and neuropeptides for their release, in order to communicate with other neurons and cells. […]
Kavli Affiliate: Michael Shadlen | Authors: Prayshita Sharma, Michael Shadlen and S Shushruth | Summary: Perceptual decision-making refers to the class of decisions in which sensory evidence is used to categorize percepts and guide actions. Conventionally, categorical decisions are thought to precede motor actions. However, recent studies in nonhuman primates challenge this assumption — when […]
Kavli Affiliate: Michael Shadlen and Mark Churchland | Authors: Elom A Amematsro, Eric M Trautmann, Najja J Marshall, LF Abbott, Michael N Shadlen, Daniel M Wolpert and Mark M Churchland | Summary: control strategies and underlying computations. How the motor system achieves such versatility remains unclear. Using high-density Neuropixels recordings from primary motor cortex (M1) […]