TMEM106B is increased in Multiple Sclerosis plaques, and deletion causes accumulation of lipid after demyelination

Posted by klaurent Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C DuBois, John R Corboy, Stephen M. Strittmatter, Hillary Guzik, Sarah Graff and Rashed M Nagra | Summary: During inflammatory, demyelinating diseases such as multiple sclerosis (MS) axonal damage is prevalent early in the disease course. Axonal damage includes swellings, defects […]


Continue.. TMEM106B is increased in Multiple Sclerosis plaques, and deletion causes accumulation of lipid after demyelination

Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

Posted by klaurent Hopkins

Kavli Affiliate: Peter Searson | Authors: Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Renee F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao and Peter C. Searson | Summary: The blood-brain barrier (BBB) plays a pivotal role in brain health and disease. In the […]


Continue.. Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

Gait Recognition in the Wild: A Benchmark

Posted by klaurent UCAS

Kavli Affiliate: Zheng Zhu | First 5 Authors: Zheng Zhu, Xianda Guo, Tian Yang, Junjie Huang, Jiankang Deng | Summary: Gait benchmarks empower the research community to train and evaluate high-performance gait recognition systems. Even though growing efforts have been devoted to cross-view recognition, academia is restricted by current existing databases captured in the controlled […]


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The Discovery of a Planetary Companion Interior to Hot Jupiter WASP-132 b

Posted by klaurent MIT

Kavli Affiliate: Sara Seager | First 5 Authors: Benjamin J. Hord, Knicole D. Colón, Travis A. Berger, Veselin Kostov, Michele L. Silverstein | Summary: Hot Jupiters are generally observed to lack close planetary companions, a trend that has been interpreted as evidence for high-eccentricity migration. We present the discovery and validation of WASP-132 c (TOI-822.02), […]


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The Discovery of a Planetary Companion Interior to Hot Jupiter WASP-132 b

Posted by klaurent MIT

Kavli Affiliate: Andrew Vanderburg, Sara Seager | First 5 Authors: Benjamin J. Hord, Knicole D. Colón, Travis A. Berger, Veselin Kostov, Michele L. Silverstein | Summary: Hot Jupiters are generally observed to lack close planetary companions, a trend that has been interpreted as evidence for high-eccentricity migration. We present the discovery and validation of WASP-132 […]


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Soft and Hard Constrained Parametric Generative Schemes for Encoding and Synthesizing Airfoils

Posted by klaurent Peking

Kavli Affiliate: Jing Wang | First 5 Authors: Hairun Xie, Jing Wang, Miao Zhang, , | Summary: Traditional airfoil parametric technique has significant limitation in modern aerodynamic optimization design.There is a strong demand for developing a parametric method with good intuitiveness, flexibility and representative accuracy. In this paper, two parametric generative schemes based on deep […]


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A 62-minute orbital period black widow binary in a wide hierarchical triple

Posted by klaurent MIT

Kavli Affiliate: Erin Kara | First 5 Authors: Kevin B. Burdge, Thomas R. Marsh, Jim Fuller, Eric C. Bellm, Ilaria Caiazzo | Summary: Over a dozen millisecond pulsars are ablating low-mass companions in close binary systems. In the original "black widow", the 8-hour orbital period eclipsing pulsar PSR J1959+2048 (PSR B1957+20), high energy emission originating […]


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The THESAN project: ionizing escape fractions of reionization-era galaxies

Posted by klaurent MIT

Kavli Affiliate: Mark Vogelsberger | First 5 Authors: Jessica Y. -C. Yeh, Aaron Smith, Rahul Kannan, Enrico Garaldi, Mark Vogelsberger | Summary: A fundamental requirement for reionizing the Universe is that a sufficient fraction of the ionizing photons emitted by galaxies successfully escapes into the intergalactic medium. However, due to the scarcity of high-redshift observational […]


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Incorporating tunability into a universal scaling framework for shear thickening

Posted by klaurent Cornell

Kavli Affiliate: Itai Cohen | First 5 Authors: Meera Ramaswamy, Itay Griniasty, James P Sethna, Bulbul Chakraborty, Itai Cohen | Summary: Recently, we proposed a universal scaling framework that shows shear thickening in dense suspensions is governed by the crossover between two critical points: one associated with frictionless isotropic jamming and a second corresponding to […]


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A neural mechanism for terminating decisions

Posted by klaurent Columbia

Kavli Affiliate: Michael Shadlen | Authors: Gabriel M Stine, Eric M Trautmann, Danique Jeurissen and Michael N Shadlen | Summary: The brain makes decisions by accumulating evidence until there is enough to stop and choose. Neural mechanisms of evidence accumulation are well established in association cortex, but the site and mechanism of termination is unknown. […]


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